Therapeutic strategies for Hypertrophic Cardiomyopathy patient with Syncope Nguyen Thi Mai Ngoc MD, PhD Viet Nam National Heart Institute Bach Mai General Hospital Definition of syncope and sudden death Syncope was defined as a sudden and brief loss of consciousness associated with a loss of postural tone and a spontaneous recovery Prognosis profiles for HCM and targets for therapy Clinical pathways in HCM Indication for ICDs in HCM Definition of syncope and sudden death Family screening for HCM patients and family members  Genetic testing  Interpretation  Genetic Counseling Characteristic & prognosis implication of myosin missense mutation in HCM:  High risk of sudden death: Mutation Arg403Gln Arg719Trp Arg453Cys  Intermediate risk of premature sudden death: Arg249Gln Glu930Lys  Carrier of other MYH7 mutations would normal risk of premature sudden death: Gly256Glu, Val606Meth, Leu908Val Xin ch©n thµnh c¶m ¬n !