         -2014             1.  2.   2014                  ,  . Tôi xin ch,    Tôi xin tr      DSCK I   , tôi s   chuyên ng         14    DUNG Trang  1 1  3 1.1. 3 1.1.1.H 3 1.1.1.3. CDB 4 1.1.1.4.  6  (ADR) 7 1.1.2.1.  7 1.1.2.2.  8 1.1.2.3.  8 1.1.2.4.  8  ADR: 9  9  10  11   13  13  15   15  18  . 18  18  20 1.5.1. 20  21  22  23 2.1. 23  23 2.1.2. 23 2.2. 23  23  30  (ADR)  30 2.2.2.2.    30 2.3 30 2.3 30 2.3   32 2.4 33 2.4.1. Phâ  33  34 3.1.   34  34  37  40  46 3.2. M  . 50  50 3.2.2.   51  54   54  60 4.1.   60  60  64  . 65  69 1. S  2010  2013 69 2.   . 69  71  72   STT  Trang 1 2.1.    23 2 2.2.        27 3 2.3.   2013 27 4 2.4.       2013 28 5 3.1 S  34 6 3.2. S ng báo cáo ADR nghiêm tr 34 7 3.3. Thi gian trì hoãn g 35 8 3.4. ng tham gia báo cáo ADR 35 9 3.5.  36 10 3.6. -10 37 11 3.7.  38 12 3.8. c báo cáo nhiu nht 39 13 3.9. Các thuc nghi ng c báo cáo nhiu nht 40 14 3.10. Tng hp phân loi báo cáo ADR theo t ch b nh ng 40 15 3.11. Biu hic ghi nhn nhiu nht 41 16 3.12. Kt qu i liên quan gia thuc  ADR 42 17 3.13. - ADR him gc ghi nhn 44 18 3.14. M nng c ADR 45 19 3.15. Biu hi- ADR phân loi  m 4 45 20 3.16. Các thông tin b thiu/không hp lý trong báo cáo ADR 47 21 3.17. m chng báo cáo trung bình 48 22 3.18. T l tham gia kho sát 50 23 3.19. ng tham gia kho sát 51 24 3.20.  cho rng báo cáo ADR là quan trng 52 25 3.21. Nhn thc v ng hp ADR cn báo cáo 53 26 3.22.  54 27 3.23. T l y t p ADR 54 28 3.24. Cách x lý c khi gp ADR 55 29 3.25. T l  56 30 3.26.  ly mu báo cáo ADR 56 31 3.27. Thi gian thc hin báo cáo ADR 57 32 3.28.  gi báo cáo ADR 57 33 3.29.   58 34 3.30. Các bi     i thin ho ng báo cáo ADR 59 DANH MỤC CÁC HÌNH STT Tên hình Trang 1 1.1 :  ADR 9 2 1.2: S ng báo cáo ADR t n 2013 20 3 3.1:  43 4 3.2:  46 5 3.3:  cáo trung bình 48 6 3.4:  52  ADR Phn ng có hi ca thuc (Adverse Drug Reaction) CBYT  ICD  10 Bng phân loi quc t bnh tt ln th 10 (International Classification of Diseases  10) KAP  (Knowledge, attitudes, practices) SOC Mã phân loại tổ chức cơ thể bị ảnh hưởng (System Organ Classes) STT S th t Trung tâm DI&ADR Quc gia Trung tâm Quc gia v Thông tin thuc và Theo dõi phn ng có hi ca thuc WHO T chc Y t Th gii (World Health Organization) [...]... [51], [62] T T M l [28] K T T [39], [42] H R [51] T R N R R [53] 1.2.2 T (under - reporting) K H S 10 .V R R [33] T N R M [40] T T I& gia 1.2.3 Bên c Tuy nhiên, K N B Q K T H N 65,5% báo c , trong [2] K R M - R N T M báo cáo Tuy nhiê T L T L V N R 11 – RQ T R [12] N tâm WHO-UMC Tuy nhiên [44] N WHO- UM mang tên VigiGrade T (completeness) (relevance) R ẽ M [26] K R V WHO – UM (C>0,8) P [26], [44] R V... T /BYT- / Y T T õ  õ : 5 [6], [8] L ― õ ‖ [14] T Y WHO R R T R [51] 1.1.1.4  R H õ  P R T õ õ K R P K K K 6 T R P R R X R  X R T R T õ T R R K T Y T T R R [4] 1.1.2 (ADR) 1.1.2.1 L R D – 05 R [14] T Y WHO gd [50], [51] 7 M i (ADR) (Adverse Drug Event - ADE) ADE m [23], [41], [56] K R gâ [65] T R R 1.1.2.2 R T R T R R S th , , type F ( , type H ( 1.1.2.3 ) U [24] ADR R [36], [38], [67], [69] V...T [9] S R (ADR) nguyên nhân quan gây ra [36] T cho N J liên quan do L M 216 R R, R R [36] T c Châu Âu Na Uy 11,5%; P N 13,0%; Anh 16%) Ú [51], [64], [68] M T ( Z 16,6% -20 R [67] Theo nghiên R [57] K USD [30] T... rung tâm õ K / / R õ 1 R ẽ I& I& T R R Q T ADR eo õ R, d [33], [65], [66] Tuy R nhiên, : M chuyên gia [33] K R T [58] V n Nẵ ‖-H V ―T ‖ N 2012 B ―T B – 2016 [11] T - B [17], [18], [19] T [15] S V Nẵ : B 2013 : 1 P R Nẵ 2 P y R 2 Nẵ C ươ 1.1 C 1 : Ổ G QU ư 1.1.1 H 1.1.1.1 T Y WHO ― Adverse Drug Reactions – ADR ‖ [48], [50] M [48]: - - P - - K - T 1.1.1.2 T T T T 3 R H õ [51], [70] Sau T [28] n S R [69]... M R rung tâm cho R V R Q /Q -BYT), x Y Y H Q R Q Y [16] T R l R 1.4.2 T / - YT Y R R R 18 R + k T T T H k Q õ +T R R K T T T K Q T T Q T T õ R T T õ [3] Q / Y -BYT T I& H M RQ T [4] T R 19 : S lư 3 2013 [16] : T I& RQ T / [15], [17] T l R T Y / N R V N 1.5 1.5.1 ẵ Hôspital de Danang, c H 20 V T Y TW H spital Indigène de Danang, sau Nẵ T Y Nẵ [72] T T M T Y Nẵ Nẵ S Nẵ S Y Q thành t Nẵ N Nẵ - N Nẵ... BSCKI, thu dung Nẵ Nẵ [1] 21 1.5.3 T Nẵ g, õ T R Nẵ R R Nẵ T R T riêng õ R R R cho trung tâm DI& ADR … Q T R R R R n Nẵ - 22 C ươ G : G G C U ư 2.1 2.1.1 R - - T R RQ DI& - Nẵ 01/ / Trung tâm 31/12 /2013 T Nẵ 2.1.2 N Nẵ T I& R Q ươ 2.2 2.2.1 M ê : N S T R H R R trung DI&ADR Q R H tâm DI&ADR Q T S c R c R I& 23 R I& S RQ Q T H R c R R I& R Q WHO T T H c R R I& ADR R Q T T H c R R I& ADR R Q T T H c . 3.8. c báo cáo nhiu nht 39 13 3.9. Các thuc nghi ng c báo cáo nhiu nht 40 14 3.10. Tng hp phân loi báo cáo ADR theo t ch b nh.  56 30 3.26.  ly mu báo cáo ADR 56 31 3.27. Thi gian thc hin báo cáo ADR 57 32 3.28.  gi báo cáo ADR 57 33 3.29.  . 3.15. Biu hi- ADR phân loi  m 4 45 20 3.16. Các thông tin b thiu/không hp lý trong báo cáo ADR 47 21 3.17. m chng báo cáo trung bình 48 22 3.18.