Journal of Hematology & Oncology This Provisional PDF corresponds to the article as it appeared upon acceptance Fully formatted PDF and full text (HTML) versions will be made available soon De novo acute megakaryoblastic leukemia with p210 BCR/ABL and t(1;16) translocation but not t(9;22) Ph chromosome Journal of Hematology & Oncology 2011, 4:45 doi:10.1186/1756-8722-4-45 Xiao Min (lfxm2000@126.com) Zhang Na (nanaxjtu@126.com) Liu YaNan (carl401860451@126.com) Li Chunrui (cunrui5650@mail.hust.edu.cn) ISSN Article type 1756-8722 Case report Submission date 27 August 2011 Acceptance date 10 November 2011 Publication date 10 November 2011 Article URL http://www.jhoonline.org/content/4/1/45 This peer-reviewed article was published immediately upon acceptance It can be downloaded, printed and distributed freely for any purposes (see copyright notice below) Articles in Journal of Hematology & Oncology are listed in PubMed and archived at PubMed Central For information about publishing your research in Journal of Hematology & Oncology or any BioMed Central journal, go to http://www.jhoonline.org/authors/instructions/ For information about other BioMed Central publications go to http://www.biomedcentral.com/ © 2011 Min et al ; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited De novo acute megakaryoblastic leukemia with p210 BCR/ABL and t(1;16) translocation but not t(9;22) Ph chromosome Author: Xiao Min1, Zhang Na1, Liu Yanan1, Li Chunrui*1 Address: 1Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie-Fang Avenue, Wuhan, Hubei, 430030, P R China E-mail: Xiao Min, lfxm2000@126.com; Zhang Na, nanaxjtu@126.com; Liu Yanan, carl401860451@126.com; Li Chunrui, cunrui5650@mail.hust.edu.cn *Corresponding author Telephone: +86-27-83662680 Fax: +86-27-83662680 Abstract Acute megakaryoblastic leukemia (AMKL) is a type of acute myeloid leukemia (AML), in which majority of the blasts are megakaryoblastic De novo AMKL in adulthood is rare, and carries very poor prognosis We here report a 45-year-old woman with de novo AMKL with BCR/ABL rearrangement and der(16)t(1;16)(q21;q23) translocation but negative for t(9;22) Ph chromosome Upon induction chemotherapy consisting of homoharringtonine, cytarabine and daunorubicin, the patient achieved partial hematological remission The patient was then switched to imatinib plus one cycle of CAG regimen (low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor), and achieved complete remission (CR) The disease recurred after 40 days and the patient eventually died of infection To the best of our knowledge, this is the first report of de novo AMKL with p210 BCR/ABL and der(16)t(1;16)(q21;q23) translocation but not t(9;22) Ph chromosome [Key words] Imatinib, Acute megakaryocytic leukemia, p210 BCR/ABL Background Acute megakaryoblastic leukemia (AMKL), also known as M7 under the French-American-British (FAB) classification, represents