NUTRITION, WELL-BEING AND HEALTH Edited by Jaouad Bouayed and Torsten Bohn Nutrition, Well-Being and Health Edited by Jaouad Bouayed and Torsten Bohn Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Jelena Marusic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published February, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org Nutrition, Well-Being and Health, Edited by Jaouad Bouayed and Torsten Bohn p. cm. ISBN 978-953-51-0125-3 Contents Preface VII Chapter 1 Dietary Derived Antioxidants: Implications on Health 1 Jaouad Bouayed and Torsten Bohn Chapter 2 Antioxidant and Pro-Oxidant Effects of Polyphenolic Compounds and Structure-Activity Relationship Evidence 23 Estela Guardado Yordi, Enrique Molina Pérez, Maria João Matos and Eugenio Uriarte Villares Chapter 3 Whole Grain Consumption and Health of the Lower Gastrointestinal Tract: A Focus on Insoluble-Bound Phenolic Compounds 49 Neal Okarter Chapter 4 Nutrition and Bone Health in Old Age 73 Manuel Díaz-Curiel, María J. Moro-Álvarez and Susana Sanz-Baena Chapter 5 Potato Antioxidant Compounds: Impact of Cultivation Methods and Relevance for Diet and Health 95 Danièle Evers and Hannah Deußer Chapter 6 Beneficial Effects of Fragrances in Beverages on Human Health 119 Hitoshi Aoshima Chapter 7 The Therapeutic Benefits of Essential Oils 155 Abdelouaheb Djilani and Amadou Dicko Chapter 8 Functional Foods Based on Traditional Chinese Medicine 179 Chunyan Yao, Ruiwen Hao, Shengli Pan and Yin Wang Chapter 9 Health-Promoting Food Ingredients and Functional Food Processing 201 Lizhe Wang and Torsten Bohn Preface Nutrition is an important lifestyle factor that contributes to our general feeling well. Recently, it has even further suggested, based on a number of epidemiological studies, that our diet is also associated with the risk of developing a number of chronic diseases, such as diabetes type II, cardiovascular diseases, osteoporosis, many types of cancer, just to name few. Thus, a balanced nutrition is firmly interwoven with many aspects of our long-term health, including the prevention of diseases, albeit this is typically rather associated with the medicinal areas. Whereas medicine however usually is brought on stage when a disease has already appeared, the strength of dietary strategies would rather rest in its preventive potential. Apart from focusing on the macro-molecules in our diet, including carbohydrates, proteins, and lipids, a number of micronutrients such as vitamins and minerals, and also phytochemicals (non-nutrients), or secondary plant metabolites, have moved into the focus of attention. Among these are the most prevalent and large group of polyphenols, the lipid soluble carotenoids, but also less well studied groups such as terpenes. Albeit still lacking hard data in terms of randomized control, double blinded intervention studies on large scales, there exist now a number of prospective cohort studies that suggest that many of these phytochemicals, when consumed within e.g. a fruit and vegetable rich diet, are important contributors to our health, and this has been further supported by a number of studies focusing on the mechanisms of their biological activity. In addition to some of the antioxidant properties, which have been attributed to these compounds, additional mechanisms, such as impacting gene transcription and therefore altering the body’s own antioxidant defense system, or inflammatory cascades, may eventually be found to be of superior importance. Much research is currently focusing on these topics, and more studies in this area are warranted to reveal the potential of many of these compounds. The knowledge that many vitamins, minerals, and phytochemicals with no direct nutritive value are important for a healthy development is not new, but can be found in many dietary approaches, such as in the Chinese Traditional Medicine, which aims at closer linking specific food items for specific health conditions and diseases, i.e. targeting to extend our common view of nutrition as merely supplying sufficient energy and essential nutrients. Functional foods and nutraceuticals also aim toward this direction, and many interesting approaches with potential health benefits are VIII Preface under consideration. Among one of these strategies are also improved technological means, such as by increasing bioaccessibility and bioavailability of certain less stable ingredients, by encapsulation. Only time will reveal the potential of these new strategies to combat chronic diseases or aid in their prevention, but new possibilities in sight of the exploding number of chronic diseases, such as the metabolic syndrome, and the increasing age pyramid, are utterly needed. This special issue is based on selected chapters that deal with the above mentioned topics. Rather then aiming at giving an exhaustive overview over “Nutrition, Well- Being and Health”, which will virtually be impossible even in a large compilation of volumes, we chose to highlight some of the recent developments and investigations in this domain. We appreciate all the efforts that were bundled to bring this book together, and we would like to express our gratitude especially toward all authors and their valuable contributions. Dr. Jaouad Bouayed and Dr. Torsten Bohn Centre de Recherche Public - Gabriel Lippmann Luxembourg [...]... such as within fruits and vegetables, which may explain the advantageous effects 10 Nutrition, Well-Being and Health of phytochemicals and nutrients in plant foods, acting additively and synergistically when consumed in a complex mixture (Bouayed and Bohn, 2010) In contrast to polyphenols, carotenoids appear to be less extensively metabolized, and are mainly excreted via bile and pancreas into the... producing and metabolizing ROS SOD, CAT, GPx, Gred and MPO mean superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and myeloperoxidase, respectively The reaction with MPO is specific for phagocytic cells Fenton reaction could also involve other transition metals GSSG and GSH stand for oxidized and reduced glutathione, respectively NAD(P)+ and NAD(P)H stand for oxidized and reduced... satisfy these two basic conditions of an antioxidant, including polyphenols and carotenoids, and some nutrients such as vitamin C or vitamin E, of which especially fruits, vegetables, and other plant foods such as whole grains, but also fish, meat, and dairy products constitute natural sources (table 2) 6 Nutrition, Well-Being and Health dietary antioxidants vitamin C quercetin carotenoids EGCG selenium*... exogenous antioxidants to maintain optimal health and prevent chronic diseases is discussed The health- promoting effects of antioxidants within fruits and vegetables are also emphasized Changes occurring during and following ingestion and digestion of bioactive compounds prior to reaching target organs and exerting their activity are also briefly reviewed 2 ROS and antioxidant defence system 2.1 ROS ROS... (2002b) Transformations of selected carotenoids in plasma, liver, and ocular tissues of 20 Nutrition, Well-Being and Health humans and in nonprimate animal models Invest Ophthalmol Vis Sci, 43(11), 33833392 Kondo, T Sharp, F.R Honkaniemi, J Mikawa, S Epstein, C.J Chan, P.H (1997) DNA fragmentation and prolonged expression of c-fos, c-jun and hsp70 in kainic acid induced neuronal cell death in transgenic... A and carotenoids and their relevance to heart disease Free Radic Biol Med, 26(5/6), 746– 761 Pandey, K.B Rizvi, S.I (2009) Plant polyphenols as dietary antioxidants in human health and disease Oxid Med Cell Longev, 2(5), 270-278 Dietary Derived Antioxidants: Implications on Health 21 Perrig, W.J Perrig, P Stahelin, H.B (1997) The relation between antioxidants and memory performance in the old and. .. 227, 25–37 22 Nutrition, Well-Being and Health Willett, W.C (2006) The Mediterranean diet: science and practice Public Health Nutr, 9(1A), 105–110 Yang, C.S Sang, S Lambert, J.D Lee, M.-J (2008) Bioavailability issues in studying the health effects of plant polyphenolic compounds Mol Nutr Food Res, 52, S139 –S151 2 Antioxidant and Pro-Oxidant Effects of Polyphenolic Compounds and Structure-Activity... Author 2 Nutrition, Well-Being and Health (Bouayed & Bohn, 2010) However, exogenous antioxidants at nutritional doses, as occurring in their natural matrices such as in fruits and vegetables, are necessary to complete the scavenging action of the endogenous antioxidant defense system Indeed, several laboratory, epidemiological, and intervention studies have suggested that antioxidants from fruits and vegetables... respectively 4 Nutrition, Well-Being and Health the abundance of CO2 following respiration The decomposition of ONOOCO2− results in the formation of •NO2 and carbonate radical (CO3•−), a ROS (Halliwell, 2006) For the above reason of multiple possibilities for interaction between nitrogen and oxygen containing reactive species, many authors usually use the collective term reactive oxygen and nitrogen... development and progression of several human diseases including cardiovascular diseases (CVD), neurological diseases and cancer, and also to the acceleration of the aging process DNA, proteins and lipids represent the major targets of the oxidative action of RONS For example, the causative link between peroxidation of lipids and lipoproteins, and several multifactorial diseases including CVD and cancer . NUTRITION, WELL-BEING AND HEALTH Edited by Jaouad Bouayed and Torsten Bohn Nutrition, Well-Being and Health Edited by Jaouad Bouayed and Torsten Bohn. GSSG and GSH stand for oxidized and reduced glutathione, respectively. NAD(P) + and NAD(P)H stand for oxidized and reduced nicotinamide adenine dinucleotide phosphate, respectively. Nutrition,. within fruits and vegetables, which may explain the advantageous effects Nutrition, Well-Being and Health 10 of phytochemicals and nutrients in plant foods, acting additively and synergistically