Tap chi lloa hoc, T. 46 (3), T, 292 - 297, 2008 NGHIEN cuu THANH PHAN HOA. HQC CAY XfCH THlJQC (PAEONIA VEITCHII LYNCH. VAR BERESOWSKII Dell I'da soan 28-3-20IJ7 PHAM HAl YEN', PHAN VAN KIEM', L12 NGOC THANH' . NGUYEN XUAN NHIEM', CH,\U VAN MINH' l\/i¢n Hod hoc cdc H(Jp cluit Thien nhien, \/i¢n Khoa hoc vel Cong ngh¢ Vi¢t Nam "Truong Dai hoc Bach Khoa Hd N(ii SUMMARY From the methanolic extract of the roots of Paeonia veitchii Lynch. val' bcresowskii Shiff pacon if/orin (1), benzoylpaconifiorin (2). gallic acid (3), gallic acid methyl ester (4), salicinol (5), isosalicin (6), benzoic acid (7), tianshic acid (8) were isolated by various chromatography methods. Their chemical structures were identified by NMR spectroscopic data. This is the firs! report of 5,6 and 8 from family Ranunculaceae, Key words: Paeonia veitchii, salicinol, isosalicin, Paeoniaceae. 1- MO DAU Cay xich thiroc c6 ten khoa hoc la Paeonia veitchii Lynch. var beresowskii Shiff (Paeoniaceae) c6 nguon goc iJvung Dong a gam Trung Quoc, Nhat Ban, Trieu Tien, Nhirng narn 1970, cay duoc di thuc trong it Sa Pa. Nhirng nghien ciru v6 thanh phan hoa h9C cho thay re cay chua chi! yeu la paeoniflorin voi ham luang khoang 2% re kho, ngoai ra con co paeonal va mot manateepen glycasid thu duoc bang each xii Iy paeaniflarin voi kali cacbanat trang metana!' Theo D6 Huy Bich va es [1] paeoniflarin co tac dung ire che than kinh, chong co that va chong viem rna it doc, Paeaniflorin co tac dung chong viern r6 ret tren mo hinh gay phu ban chan chuot cong trang. Trang y h9C co truyen, xich thuoc duoc dung M tri cac benh dau nrc nguc, chay mau duoi da, viem tac dong mach, viern rnang phoi do lao, xa gan, viern nha chu, mun nhot v.v Trang y h9C co truyen Trung Quoc, xich thuoc con duoc dung lam thuoc giam dau, cam mau va khang 292 khuan, va la mot thanh phan trang che pham thuoc Trung Quoc dieu tri benh ung thu va tim mach [11. Bai baa nay thong baa kct qua nghien ctru thanh phan hoc, hoc cua cay thuoc qui nay. Bang cac phuong phap sac ky, 8 hop chat da dtroc phan lap til dich chiet metanal cua re cay la paeoniflorin (1), benzoyl paeoniflorin (2), axit galic (3), metyI gaIat (4), salicinol (5), isosalicinol (6), axit benzoic (7) va axit tianshic (8). Can true cua cluing diroc xac dinh bang cac phuong phappho. II - THl/C NGHII;;M VA PHUONG PHAP NGHIENCDtJ L Phuong phap chnng a) Phuong pluip phanlap cdc hop chat SAc ky 16p mong (TLC): SAc ky lop m6ng dieu che duoc thuc hien tren ban rnong trang siln DC-Alufolien 60 F", (Merck 1,05715), RP" F'>4' (Merck). Phat hien chat bang den til" ngoai 6 hai buoc song 254 nm va 368 nm hoac dung . class="bi x0 y0 w1 h1 4" alt =""