[...]... in the Laboratory of Preclinical Pharmacology at the National Institute of Mental Health (Washington, DC, 1970), under the able direction of Erminio Costa, M.D., an eminent member of the National Academy of Sciences Dr Ebadi served as chairman of the Department of Pharmacology at the University of Nebraska College of Medicine from 1970 until 1988, and subsequently as professor of pharmacology, neurology,... 1988 through 1999 In July of 1999, he was appointed professor and chairman of the Department of Pharmacology and Toxicology at the University of North Dakota School of Medicine and Health Sciences In September of 1999, Dr Ebadi became professor and chairman of the newly created Department of Pharmacology, Physiology, and Therapeutics; in November 1999, he became professor of neuroscience; and in December... publication of the first edition of CRC Desk Reference of Clinical Pharmacology in 1998, dramatic discoveries in molecular medicine, along with rapid concomitant technological advances, have revolutionized the diagnosis and treatment of a broad range of human diseases with new medications Given the rapid pace of new discovery, genetic- and cell-based therapeutics have now become a common part of the physicians’... attempt has been made to be comprehensive, authoritative, and accurate in the expanded and improved second edition of the CRC Desk Reference of Clinical Pharmacology The first five chapters present discussions of the Pharmacokinetic Basis of Therapeutics, Concepts of Pharmacodynamics, and the Principles of Drug–Drug Interactions and Drug–Food Interactions Moreover, whenever possible, the interactions... inhibition of smooth muscle cell proliferation Decreased thrombus formation, increased fibrinolysis Normalized sarcomere function Angiogenesis Improved calcium handling, increased contractility Adiopectin The second edition of the CRC Desk Reference of Clinical Pharmacology is designed specifically for physicians, pharmacists, nurses, and other members of the health care delivery team It consists of three... of CRC for their help and professionalism The author hopes that by providing simple and unique diagrams, comprehensive tables, and more than 2000 entries, the CRC Desk Reference of Clinical Pharmacology will become a valuable and essential reference book for physicians and other members of the medical profession in their quest to alleviate the mental and physical sufferings of their fellow human beings... Comparison of the Hemodynamic Effects of Calcium-Channel Antagonists 493 Parenteral Medications Used in the Treatment of Hypertensive Emergencies 501 Comparative Pharmacology of Penicillin Derivatives 556 Drugs Used in the Treatment of Chronic Postural Hypotension 598 Sites of Action of Diuretics 684 Classification of Vasodilators by Peripheral Site of Action... membranes of subcellular organelles of neurons An understanding of how drugs traverse various cellular and subcellular membranes is of clinical significance, in terms of attaining the desired therapeutic level of an administered agent Multiple physical and chemical factors influence the rate and extent of absorption of drugs These include: Physiochemical factors Molecular weight The degree of ionization... administration of a drug is the first-pass effect, which consists of the loss of a drug as it passes through the liver for the first time For example, nitroglycerin, which is used in the management of patients with angina pectoris, is given sublingually DESK REFERENCE OF CLINICAL PHARMACOLOGY Taken orally, nitroglycerin is rapidly inactivated in the liver, and the resulting concentration is inadequate to be of immediate... 208 Actions of Glucocorticoids 305 GnRH Analogs with Agonist Activity 310 Summary Pharmacology of Nitrous Oxide, Cyclopropane, Halothane, and Ether 318 Pharmacology of Heparin and Coumarin 321 Comparison of Hirudin and Heparin as Anticoagulants 321 Properties of Insulin Preparations 354 Comparison of Features of Antithyroid . improved second edition of the CRC Desk Reference of Clinical Pharmacology. The first five chapters present discussions of the Pharmaco- kinetic Basis of Therapeutics,. include: The second edition of the CRC Desk Reference of Clinical Pharmacology is designed specifically for physicians, phar- macists, nurses, and other members of