... celiac disease is unknown, but it may be secondary to elevations in inflammatory mediators, autoimmune processes or, in some cases, secondary to iron-deficiency anemia or functional hyposplenism. ... cases. 67-69 Thrombocytosis in association with CD appears to be more common than thrombocytopenia, occurring in up to 60% ofpatients. 70-72 The etiology of thrombocytosis associated with celiac ... celiac disease thrombocytosis was present and it was unrelated to iron deficiency or an inflammatory syndrome. Among patients with thrombocytosis, 6 had an associated autoimmune disease, but...