Tài liệu Color Atlas of Pharmacology (Part 26 and the end): Further Reading doc

... toxicology: the basicscience of poisons. 5thed. New York:McGraw-Hill; 1995.332 Further Reading Lüllmann, Color Atlas of Pharmacology © 2000 ThiemeAll rights reserved. Usage subject to terms and ... 350Lüllmann, Color Atlas of Pharmacology © 2000 ThiemeAll rights reserved. Usage subject to terms and conditions of license.333Drug IndexesNomenclature. The terms active agent and pharmacon ... some other commerciallysuccessful drugs are sold under morethan 20 different brand labels. The num-ber of proprietary names, therefore,greatly exceeds the number of availabledrugs.For the...

Tài liệu Color Atlas of Pharmacology (Part 24): Disinfectants ppt

... invade the intestines oreven internal organs, and are mostlymembers of the phyla of flatworms and roundworms. They are combated withanthelmintics.Anthelmintics. As shown in the ta-ble, the ... A,but is more potent and efficacious. The monoclonal antibodies daclizu-mab and basiliximab bind to the α-chain of the II-2 receptor of T-lympho-cytes and thus prevent their activation,e.g., ... The sulfonamide sulfadoxine inhibits syn-thesis of dihydrofolic acid (p. 272). Chlo-roquine and quinine accumulate within the acidic vacuoles of blood schizonts and inhibit polymerization of...

Tài liệu Color Atlas of Pharmacology (Part 25): Therapy of Selected Diseases pptx

... contraction of abdominal wallmuscles and diaphragm. Closure of the glottis and elevation of the soft palateprevent entry of vomitus into the tra-chea and nasopharynx. As a rule, thereis prodromal ... relieving these symptoms.324 Therapy of Selected DiseasesLüllmann, Color Atlas of Pharmacology © 2000 ThiemeAll rights reserved. Usage subject to terms and conditions of license.Therapy of Selected ... or both of these determinants. The therapeuticutility of antihypertensives is deter-mined by their efficacy and tolerability. The choice of a specific drug is deter-mined on the basis of a benefit:risk...

Tài liệu Color Atlas of Pharmacology (Part 1): History of Pharmacology pptx

... transparent and affording an overview of the pharmaco-logical basis of drug therapy. The authors wish to reiterate that the Color Atlas of Pharmacology cannot replace atextbook of pharmacology, ... terms and conditions of license.re K III Color Atlas of Pharmacology 2ndedition, revised and expandedHeinz Lüllmann, M. D.Professor EmeritusDepartment of Pharmacology University of KielGermanyKlaus ... Pharmakologie. English. Color atlas of pharmacology / Heinz Lullmann … [et al.] ; color plates by Jurgen Wirth. — 2nd ed., rev. and expanded.p. cm.Rev. and expanded translation of: Taschenatlas der Pharmakologie.3rd...

Tài liệu Color Atlas of Pharmacology (Part 2): Drug Administration doc

... number of drops, the size of which depends on the area of the drip opening at the bottlemouth and on the viscosity and surfacetension of the solution. The advantage of a drop solution is that the ... front of the mouth, the size of aerosol particles, and the coordi-nation between opening of the sprayvalve and inspiration. The size of aerosolparticles determines the speed at whichthey are ... During use, the in-haler (spray dispenser) is held directlyin front of the mouth and actuated at the start of inspiration. The effective-ness of delivery depends on the position of the device...

Tài liệu Color Atlas of Pharmacology (Part 3): Distribution in the Body docx

... Fenestrat-ed endothelia are found in the capillar-ies of the gut and endocrine glands.In the central nervous system(brain and spinal cord), capillary endo-thelia lack pores and there is little ... are-as of the skin.22 Distribution in the BodyLüllmann, Color Atlas of Pharmacology © 2000 ThiemeAll rights reserved. Usage subject to terms and conditions of license.Distribution in the Body ... 23A. External barriers of the bodyNonkeratinizedsquamous epitheliumCiliated epitheliumKeratinized squamousepitheliumEpithelium withbrush borderLüllmann, Color Atlas of Pharmacology © 2000...

Tài liệu Color Atlas of Pharmacology (Part 4): Drug Elimination doc

... the carboxyl groups of the ac-ceptor and the amino group of the do-nor molecule (e.g., formation of salicyl-uric acid from salicylic acid and glycine). The acidic group of glycine or glutamineremains ... dealkyla-tions. In the case of primary or secon-dary amines, dealkylation of an alkylgroup starts at the carbon adjacent to the nitrogen; in the case of tertiaryamines, with hydroxylation of the nitro-gen ... subject to terms and conditions of license.Elimination of Lipophilic and Hydrophilic Substances The terms lipophilic and hydrophilic(or hydro- and lipophobic) refer to the solubility of substances...

Tài liệu Color Atlas of Pharmacology (Part 5): Pharmacokinetics docx

... to the half-life(t1/2) and the apparent volume of distri-bution Vapp(p. 28) by the equation:Vappt1/2= In 2 x ––––Cltot The smaller the volume of distribu-tion or the larger the ... in-cluding the speed of drug dissolution (in the case of solid dosage forms) and of gastrointestinal transit; the membranepenetrability of the drug; its concentra-tion gradient across the mucosa-bloodbarrier; ... level (cmax), the higher will be the cmax, and the earli-er the plasma level will begin to fallagain. The area under the plasma level timecurve (AUC) is independent of the route of administration,...

Tài liệu Color Atlas of Pharmacology (Part 6): Quantification of Drug Action ppt

... requires deter-mination of the EC50, the maximallypossible effect (Emax), and the slope at the point of inflection.54 Quantification of Drug ActionLüllmann, Color Atlas of Pharmacology © 2000 ... ligands, the kinetics of inter-action, and the characteristics of the binding site itself.In studying the affinity and number of such binding sites, use is made of membrane suspensions of different ... purifying and analyzing further the receptor protein.56 Quantification of Drug ActionLüllmann, Color Atlas of Pharmacology © 2000 ThiemeAll rights reserved. Usage subject to terms and conditions of...

Tài liệu Color Atlas of Pharmacology (Part 7): Drug-Receptor Interaction doc

... change in the in-tensity of the effect. The dose dependence of the timecourse of the drug effect is exploitedwhen the duration of the effect is to beprolonged by administration of a dosein ... conditions,a smaller proportion of the dose admin-istered is eliminated per unit of time. The time course of the effect and of the concentration in plasma are notidentical, because the concentration-effect ... present, increasing the concentration of the agonist can restore the full effect (C). However, in the pres-ence of the antagonist, the concentra-tion-response curve of the agonist isshifted...

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