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Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"

Báo cáo y học:

Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"

... Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis Zhong Zhao1,2, Dale J. Lange1,3 ,Lap Ho1,2, Sara Bonini1,2, ... immunocyto-chemically revealed that Vgf immunoreactive material in spinal cord motorneurons is already decreased in ~75 day old asymptomatic SOD-1 G9 3A- SOD1 ALS mice and continue to decrease as a ... Yamaguchi H, Sasaki K, Satomi Y, Shimbara T, Kageyama H, Mondal MS, Toshinai K, Date Y, Gonzalez LJ, Shioda S, Takao T, Nakazato M, Minamino N. Peptidomic identification and bio-logical validation of...
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Báo cáo y học: "Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units"

... between 28% and 54%.Eosinopenia was a sepsis marker in our study. The study by Giland colleagues in a department of internal medicine showedthat an inflammatory syndrome associated with an eosinophilcount ... mg/dl.Statistical analysesData are presented as the mean ± standard deviation for vari-ables with a normal distribution, and as the median and inter-quartile range for variables with skewed distributions.Parametric ... common causes of morbidity andmortality in the intensive care unit (ICU) [1]. Sepsis is generallycharacterized by clinical and laboratory parameters that arenot specific and can mislead because...
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Báo cáo Y học: Structural and serological relatedness of the O-antigens of Proteus penneri 1 and 4 from a novel Proteus serogroup O72 pptx

Báo cáo Y học: Structural and serological relatedness of the O-antigens of Proteus penneri 1 and 4 from a novel Proteus serogroup O72 pptx

... polysaccharides in a yield of20% of the LPS mass.Rabbit antisera and serological assaysPolyclonal O-antisera were obtained by immunization ofrabbits with heat-inactivated bacteria of P. penneri 1and4according ... etrasaccharide (strain 1 ) and pentasac-charide (strain 4) repeating units of the polysaccharides wereestablished: In the polysaccharide of P. penneri strain 4, glycosylation with the lateral ... LC-2000 amino-acid analyser on a Ostion LGAN B cation-exchange resin in the standard 0.35Msodium citrate buffer pH 5.28 at 80 °C. Neutral sugarswere analysed with a Biotronik LC-2000 sugar analyseron...
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Báo cáo Y học: The Emery–Dreifuss muscular dystrophy associated-protein emerin is phosphorylated on serine 49 by protein kinase A pptx

Báo cáo Y học: The Emery–Dreifuss muscular dystrophy associated-protein emerin is phosphorylated on serine 49 by protein kinase A pptx

... Professor.References1 Nagano A, Koga R, Ogawa M, Kurano Y, Kawada J,Okada R, Hayashi YK, Tsukahara T & Arahata K(1996) Emerin deficiency at the nuclear membrane in patients with Emery–Dreifuss muscular dystrophy. ... A (PKA) and we have confirmed thisusing an in vitro protein kinase assay. Potential signaltransduction pathways that could be involved in phos-phorylating emerin on residue S49 and how they ... programme)spanning human emerin residues 1–199. They cover a wide range of kinases, including protein kinases A and C, casein kinase II and tyrosine kinases. We havepreviously shown that four...
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Báo cáo Y học: Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity pot

Báo cáo Y học: Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity pot

... constant level ofintact IGFBP-4 in murine pregnancy was caused by anincrease in synthesis along with increased proteolysis.The presence of PAPP -A mRNA in all murine tissuesanalyzed parallels the ... USAMurine pregnancy -associated plasma protein -A (PAPP -A) cDNA encoding a 1545 amino-acid protein has been cloned.We have also identified and cloned cDNA that encodes a novel variant of PAPP -A, PAPP-Ai, ... recombinant murine pregnancy -associated plasmaprotein -A (PAPP -A) and a novel variant (PAPP-Ai) with differentialproteolytic activityRikke Søe1, Michael T. Overgaard1, Anni R. Thomsen1, Lisbeth...
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Báo cáo Y học: Functional studies of the Synechocystis phycobilisomes organization by high performance liquid chromatography on line with a mass spectrometer docx

Báo cáo Y học: Functional studies of the Synechocystis phycobilisomes organization by high performance liquid chromatography on line with a mass spectrometer docx

... chromatogram abundant in hydrophilic proteinssuch as linkers and a significant amount of a- andb-phycocyan ins, and only traces of the allophycocyanins.On the contrary, HPLC a nalysis of bands 2–5 ... containedless b-phycocyanin; this only had a marked effect on band 5,the heaviest one, consistent with th e idea that this bandcontains mainly b-phycocyanins. Probably during nitrogenstarvation ... thatadaptation of cyanobacterial phycobilisomes to light bycomplementary chromatic adaptation is a complex processthat changes the ratio of phycocyanin to phycoerythrin in rods of certain...
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Báo cáo Y học: Identification of novel membrane proteins by searching for patterns in hydropathy profiles potx

Báo cáo Y học: Identification of novel membrane proteins by searching for patterns in hydropathy profiles potx

... profilesare displayed in a convenient format. This approach can beused to search for new members of a family or functionalclass of membrane protein. It can assist with functionalanalysis, and may ... Mostmembrane -associated domains produce an easily identifiedpeak in the hydropathy profile of the polypeptide. Standardsoftware tools are available that can identify the putativetransmembrane domains ... peak count (Fig. 2A) .Sometimes a false hydropathy peak is detected at a location that is not a transmembrane domain, and truetransmembrane peaks are occasionally missed. Thus, whensearching...
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt

Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt

... form a family of related proteinsharboring several highly conserved domains, such as anN-terminal variant SH2 domain, a RING finger and a C-terminal proline-rich domain containing potential tyro-sine ... proteolysis, causing an accumulation of proteinsthat are usually degraded by this pathway [22]. In contrastto lactacystine, which is a highly specific proteasomalinhibitor [23], ALLN inhibits also nonproteasomalproteases, ... ubiquitous kinase (Ruk) protein, alsoknown as CIN85 or SETA, is an adaptor-type proteinbelonging to the CD2AP/CMS family. It was found in complexes with many signaling proteins, including phos-phoinositol...
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Báo cáo Y học: Synthesis, conformational analysis and biological activity of cyclic analogs of the octadecaneuropeptide ODN Design of a potent endozepine antagonist pot

Báo cáo Y học: Synthesis, conformational analysis and biological activity of cyclic analogs of the octadecaneuropeptide ODN Design of a potent endozepine antagonist pot

... respectively, as an agonist and anantagonist of the metabotropic receptor which mediatesthe ODN-induced [Ca21]iincrease in rat astrocytes.It has been previously shown that a vacant C-terminalcarboxylic ... processes by analyticalRP-HPLC revealed that the N a -Fmoc group was not totallystable in reductive media. This observation was at variance with the data reported by Carpino & Han [28], who ... 6057Synthesis, conformational analysis and biological activity of cyclicanalogs of the octadecaneuropeptide ODNDesign of a potent endozepine antagonistJe´roˆme Leprince1, Hassan Oulyadi2,...
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Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"

... and categorical variables for the pre-dictors of SVR were compared by using logistic re-gression and multivariate analysis (categorical data) as displayed in Table 3. In multivariate analysis, ... continuous data was evaluated by the O’Brien test for homogenicity of variances. When necessary, an appropriate normalizing or variance stabilizing transformation was applied. Analysis of variance was ... ethnicity, injection drug use, viral load, anemia, alanine transaminase level, and liver histology and did not reach statistical sig-nificance. Table 1: Baseline demographic, clinical characteristics...
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