... N-termini of RGS8 protein[19,20]. The N-terminal deletion of RGS8 resulted in aremarkable decrease in the inhibitory effects of RGS8on Gaq-coupled responses. The nine amino acids in theN-termini ... of Biological Science, Allergan, Inc., Irvine, CA, USAHeterotrimeric guanine nucleotide-binding proteins(G proteins) comprise a superfamily that is involved in the transmission of ligand binding ... RGS5s proteins. T, total protein; M, mem-brane protein; C, cytosolic protein. Arrows indicate a 26 kDa protein of RGS5 and a 13 kDa protein of RGS5s.Alternative mRNA splicing variant of RGS5 Y....