... SH2domain; pYDEP, pYDED and pYDEV for the NckSH2 domain; pYLNV, pYLNV, pYIN and pYMN for the Sem5 SH2 domain; pYMXM, pYVXM, pYIXM and pYEXM for the N-terminal SH2 domain of p85;pYXXM for the C-terminal ... C-terminal SH2 domain of p85; pYVIP,pYILI and pYILV for the C-terminal SH2 domain of PLC-r; pYELE, pYIDI and pYVDV for the N-terminalSH2 domain of PLC-r; and pYIXV, pYVXI, pYVXL and pYVXP for the ... by the Tyr304 phosphorylation isindependent of phosphorylations at the other two tyrosineresidues, Tyr311 and Tyr316.To further assess the binding specificity of the Grb4 SH2domain, we synthesized...