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Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"

Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc

Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc

... 269) 1327 they are represented by the MH-2L formula, where M isCu(II) or Ni(II). For DAHK there a re two such complexes,MH-1L and MH-2L, differing by the protonation state of the lysine amine, ... b(HnL), j and n ¼ 2, except for DAHKam, where j ¼ 1 and n ¼ 3.bNi(II) data from ref [11].c[31].d[36].eglycylglycylhistamine, [9].fa-hydroxymetylseryl-a-hydroxymetylserylhistidinamide; Cu(II) ... partially sh ielded from solution by the rest of the protein. There is no correlation between the complex stability and the rate of its formation. The Ni(II) for Cu(II) exchange rates f or peptides are...
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Tài liệu Báo cáo Y học: Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors potx

Tài liệu Báo cáo Y học: Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors potx

... invertebrates. The bases for these differences, despite the highsimilarity of the SRF amino-acid sequences in the MADSbox and SAM-domain sequences, are not known. SRFregulatory pathways could have ... equivalent positions in the cDNA clones of the threespecies, immediately downstream of the MADS-box codingregion, was used for making these constructs. The hybridmolecules coded for the N-terminal ... according to their components: the species contributing the N-terminal part of the proteinis indicated by the first letter and the species that provides the C-terminal region by the second letter...
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Báo cáo y học: "Bench-to-bedside review: The MET syndrome – the challenges of researching and adopting medical emergency teams"

... in efficacy. Short-term studiesmay therefore underestimate its impact [34]. RRSs with theirMET components are not easy, nor are they simple. Yet, theyare worth the effort.Critical Care Vol ... of critically ill patients is their core specialtycompetency, intensive care doctors and nurses are ideallyplaced to provide immediate care to patients who arecritically ill: they are acute illness ... technology andprocesses of care are necessary to minimise these problems.Major delays in calling a medical emergency teamDespite positive attitudes toward the MET system, nursesmay not always follow the...
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Báo cáo y học:

Báo cáo y học: "Spindle Cell Lipoma of the Hypopharynx"

... Lipoma, Hypopharyngeal lipoma Introduction Lipomas are the most frequently observed soft tissue tumors in adults. They commonly occur in the neck and on the trunk, and are frequently located ... located at the subdermal, while rarely at the dermal tissue layer. They are commonly found at the dorsal neck, nape, shoulders, and the back1. Spindle cell lipoma was first defined by Enzinger ... origi-nating from the mature lipid tissue1. They constitute approximately 0.6% of the laryngeal and hypopha-ryngeal benign tumors4. Laryngeal and hypopharyn-geal lipomas first appeared in...
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Báo cáo y học:

Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"

... the level of the orbital roof, and by the age of 10 years, the sinuses extend into the vertical portion of the frontal bone. The final adult proportions are reached only after puberty ... until about the age of 6 years. Their develop-ment is quite variable but effectively appears to start only after the second year of life [4,8,9]. By the age of 4 years, the average ... extent of the frontal sinus reaches half the height of the orbit and extends just above the top of the most-anterior ethmoid cells. By the age of 8 years, the top of the frontal...
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Báo cáo y học:

Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"

... minutes, which then switched to the opposite polarity for another 11.5 minutes. The device was designed to switch the di-rection of current flow halfway through the cycle. The resulting cycle time ... one polarity for 11.5 minutes, which then switched to the opposite po-larity for another 11.5 minutes. The resulting cycle time is approximately 23min or 0.000732 Hz and delivers a square wave ... ß-cells are par-ticularly sensitive to reactive oxygen species because they are low in antioxidant enzymes such as catalase, glutathione peroxidase, and superoxide dismutase (35). Therefore, the...
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Báo cáo y học:

Báo cáo y học: "Godoy & Godoy technique in the treatment of lymphedema for under-privileged populations."

... slid along the route of the lymphatic vessels, promotes the formation of lymph. Thus, using the principles of hydrodynamics, physi-ology, physiopathology and anatomy, a new concept of lymph drainage ... until the patients are aware of the precautions they need to take. Another line of research is related to myolym-phokinetic exercises; there is a scarcity of publications on this subject in the ... compression on the vessels; the au-thors suggest the use of the term ‘myolymphokinetic therapy’ when these activities or exercises result in a volumetric reduction of the limb. These exercises are specific...
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Báo cáo y học:

Báo cáo y học: " Vacuum-assisted closure in the treatment of early hip joint infection"

... unknown whether the polyurethane sponges of the V.A.C. – system would have the same outcome as the polyvinylalcohol sponges did in the present study. Equally to that, our results account only for an ... of the V.A.C.-therapy, thus being probably the reason for the system failure in the infection treatment in case 10. One limitation of our study is that we cannot define the ideal frequency for ... necroses, then the V.A.C.-therapy should not be used for infection management of the underlying implant. Moreover, the virulence of the causative pathogens, the severity of infection and the host...
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Báo cáo y học:

Báo cáo y học: " Two-stage procedure in the treatment of late chronic hip infections spacer"

... conventionally have to fulfil the criteria estab-lished by Murray [24] including: antibiotic safety, thermostability, hypoallergenicity, water solubility, adequate bactericidal spectrum and availability ... non-articulating spacers, medullary dowels, and articulating or mobile spacers. Despite the superior elution properties of ALC beads [34], they are rarely advocated nowadays due to the associated limb shortening ... used for the primary procedure, bacteria causing the infection may have already survived high con-centrations of that antibiotic and will likely be resis-tant if the same antibiotic is used in the...
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Báo cáo y học:

Báo cáo y học: "Effect of antibodies on the expression of Plasmodium falciparum circumsporozoite protein gene"

... detection of specific products was performed with the GeneAmp® 5700 system (PE Applied Biosystems) using the following cycle profile: 1 cycle at 48°C for 30 min, 1 cycle at 95°C for 10 min, 40 cycles ... performed in all assays. The quantity of cDNA for csp was normalised to the quantity of the house keeping gene ldh cDNA in each sample. Melting curves were used to determine the specificity of ... parasite development in the sporogonic [3 - 5], exoerythrocytic [6] and erythrocytic [7] cycle. However, there is almost no information on the effect of antibodies on the expression of Plasmodium...
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