...
they are also used as aromatics. Because of their pharmacological e ect, alkyl nitrites are being
abused as uncontrolled inhalant drugs and causing a social problem [4]. Although there are
many ... mg/mL), and kept airtightly
in a refrigerator. A 5- L volume of the above solution is placed using a microsyringe in a
glass vial containing 1 mL of dimethyl sulfox...
... toxicity of VX in humans; there are only estimated values based on the experimental
GC/MS analysis for DAEMS in serum. (a) a total ion chromatogram (TIC) and a mass chromato-
gram; (b) an EI mass ... secondary exposure for
an analyst; the manipulations including the above evaporation should be done inside a
dra chamber.
f) For quantitative analysis of DAEMS, various c...
... 2.3
EI mass spectra of ∆
9
-THC, CBD, CBN and 5α-cholestane.
GC analysis of cannabinoids in plant specimens
190 Cannabinoids and their metabolites
GC/MS analysis of ∆
9
-THC-11-oic acid in urine ... resin of the cannabis plant. Since the main component of cannabis, ∆
9
-tetrahydrocannabi-
nol ( ∆
9
-THC), has various psychopharmacological e ects including hallucinatio...
... concentrations
206 Morphine and its analogues
8) Matsubara K, Fukushima S, Akane A et al. (1992) Increased urinary morphine, codeine and tetrahydropapavero-
line in Parkinsonian patient undergoing L-3,4-dihydroxyphenylalanine ... Nanzando, Tokyo, pp 230–234 (in Japanese)
196 Morphine and its analogues
Main metabolic pathways of morphine, heroin and codeine. The thick and thi...
... methemoglobinemia be-
comes severe, it causes cyanosis, headache, easy fatigability, respiratory and conciousness dis-
turbances and nally death. e fatal methemoglobinemia is rare, but fatal ones a ...
GC.
vi. Various known amounts of nitrate and a xed amount of IS are added to blank specimens
and processed in the same way to construct a calibration curve. e peak a...
... of his ingestion and death. In addi-
tion, the ratios of cocaine to BE in blood and in the brain, and the brain-to-blood ratios of
cocaine and BE were compared with those described in literature ... mass spectra of the authentic cocaine, EME and BE a er derivatization.
Setting up of cuto values are very common in USA and Europe as a part of QC ( quality...
... commercially avail-
able.
ii. Preparation
• Pentazocine and dextromethorphan solutions: the drugs are separately dissolved in appro-
priate amount of methanol; a 10–20 µL aliquot was added to 1 mL of ... the calibration curve, which is composed of pen-
221
tazocine concentration in the horizontal axis and peak area ratio of pentazocine to IS in the
vertical axis. e p...
... digestive tract is rapid and distinct visual hallucination takes place
45 min–1 h a er oral intake of about 20 µg of LSD [1]. e hallucination becomes most marked
2–3 h a er the intake and lasts ... powerful hallucinogenic
drugs of abuse. LSD was explosively abused in U.S .A. in the latter half of the 1960s. In Japan,
the amount of seizure of LSD is much smaller...
... H, Nakajima K, Nishikawa M et al. (1991) Determination of methamphetamine and amphetamine
in urine by headspace gas chromatography/mass spectrometry. Anal Sci 7:19–22
25) Shima N, Kamata T, ... hyperthermia, rhabdomyolysis, acute renal failure, dis-
seminated intravascular coagulation and death [19, 20]. A detailed review by Kalant [16] re-
vealed that 87 MDAs-related fatalities we...