... Fasano31Department of Chemistry ‘IFM’, University of Torino, Italy;2Department of Biology, University ‘Roma Tre’, Rome, Italy;3Department of Structural and Functional Biology, University of Insubria, ItalyHaem ... the N-form [1,3,4,14,35,36]. Haem inhibitsdrug binding, possibly stabilizing the N-species of HSA(present study). Accordingly, binding of ibuprofen andwarfarin to Sudlow’s site I impairs ferric ... occurring in HSA upon ligand binding. Note thatthe flexibility of the HSA structure allows it to adaptreadily to ligands and that its three-domain design providesa variety of binding sites. In...