Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&
Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&
... for citation purposes)Child and Adolescent Psychiatry and Mental HealthOpen AccessResearchDoes switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect ... AbstractBackground: To evaluate health-related quality of life (HRQL) and medication satisfaction after switching from a stable doseof oral extended-release methylphenidate (ER-MPH) to methylphenidate transdermal ... satisfaction with theduration of effect of the study medication on their child'sADHD symptoms.Regarding medication satisfaction with tolerability ofMTS, at study endpoint the majority of caregivers...
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Báo cáo y học: "An Avian Connection as a Catalyst to the 1918-1919 Influenza Pandemic"
... ability to follow the travel routes from city to city and sicken large numbers quickly and killing the very young and very old. The association of avian influenza with the 1918 pandemic has not ... became ill with the flu. Washings were obtained from the researcher’s throat and sprayed the filtrate into healthy ferrets’ respiratory tracts. The ferrets became ill with the same symptoms [2, ... type”, and or the conditions necessary to prevent the reappearance of this influenza. Unlike the typical “flu” that strikes the very young, chronically ill and elderly; this flu would attack and...
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Báo cáo Y học: Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC Fluorescence resonance energy transfer and crystallographic study ppt
... respectively, thick lines); C9 and C10 correspond to the position of these atoms in the OA_A ligand, where the electron densitywas visible from its carboxylic group up to the C9-C10 carbon atoms: the ... appropriate substitute for the wild-type Thermomyceslanuginosa lipase for mimicking the interaction between the wild-type enzyme and lipids.Keywords: lipase; X-ray crystallography; cis-parinaric ... tryptophan of the TLL and that the lid region isdirectly involved in the binding of TLL to micelles of the pentaoxyethylene octyl e ther (C8E5)detergent[32].In the absence of NaTDC, with...
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Báo cáo y học: "Does Flavanol Intake Influence Mortality from Nitric Oxide-Dependent Processes
... in the islands was very much influenced by the mortality in the very young, primarily due to diarrhea. As an index of aging, we examined the age distribution on the mainland and in the islands ... over 5 years for the 4 conditions specified in the hypothesis that a very high dietary intake of flavanoids might predict. Note the remarkable year -to- year consistency in Panama and the very much ... x-ray, angiography, ultrasound examination, the electrocardiogram, and occasionally a biopsy. The availability of the laboratory examination probably differs in the San Blas and the mainland,...
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Báo cáo y học: "Severe Anisocoria after Oral Surgery under General Anesthesia"
... Traumatic or hypoxemic injuries of the sympa-thetic nervous system may be the cause of Horner’s Syndrome, which refers to a group of signs produced when sympathetic innervation to the eye is ... immediately ana-lyzed and considered incompatible with the treatment performed. In order to achieve diagnostic certainty, we per-formed Computed Tomography (CT) in the emer-gency setting, ... aniso-coria. The photographic monitoring of anisocoria in the post-operative period, and the relative brevi ty of unilateral mydriasis, empirically confirmed the di-agnosis and the benign...
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Báo cáo Y học: A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis H37Rv and the secreted chorismate mutase (y2828) from Yersinia pestis pptx
... activity bytryptophan and tyrosine are denoted as AroQb.Secreted CMs such as *MtCM and *YpCM, in which the catalytic site is formed within a single protomerbut without an apparent regulatory ... helix 3 of the second EcCM protomer; in *YpCM, the disulfide bond is between the third residue of the mature protomer and the bottom of helix 1 of the second EcCM protomer, Cys33 and Cys148.Classification ... indi-cated for the second chain. The citrate from the crystal structure of*YpCM is shown in the active site with yellow carbon atoms in (C).All of the active site residues belong to the same chain. The...
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Báo cáo Y học: Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? ppt
... itsavailability for eIF4F complex formation [12]. These effectsmay be associated with the role for eIF4E in enhancing the export of the mRNA for cyclin D1 from the nucleus to the cytoplasm. The shuttling ... thought to transfer eIF4E to the nucleus, where it appears to beimportant in transporting the cyclin D1 mRNA to the cytoplasm [13]. The increase in cyclin D1 expression is likely to promote G1 to ... important issue. Their work was performedbefore the identification of the Mnks, and they usedchromatography on RNA-cellulose to separate phosphor-ylated from unphosphorylated eIF4E. The fraction...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... aheme covalently attached to the polypeptide chain via twothioether bonds, formed from the vinyl groups of the heme and the two cysteine residues in the consensus Cys-X-X-Cys-His motif [1–4]. ... areadvantageous for determining the amino-acid residuesresponsible for protein stability. The heterologous expressionsystems established for cytochrome c, together with the results from rapidly increasing ... holopro-tein in the E. coli cytoplasm similar to the case of HT c-552[26]. Although the cytoplasmic holo-(TT c-552) has the same function and spectra as the authentic one, the cytoplasmic soluble...
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Báo cáo Y học: Pyruvate decarboxylase from Kluyveromyces lactis An enzyme with an extraordinary substrate activation behaviour pptx
... decarboxylase (2-oxo acid carboxylyase, EC 4.1.1.1); ByPDC, pyruvate decarboxylase from brewer’syeast; KlPDC, pyruvate decarboxylase from Kluyveromyces lactis;PsPDC, pyruvate decarboxylase from ... the weaker the binding of the activating substrate molecule to the regulatory centre and/ or the more unfavoured is the activated state against the inactive one, the larger the deviation from the Michaelis–Menten ... pyruvate concentrations. The regulatory site of KlPDC shows a very low affinity for the primary binding of the substrate (Table 2) compared to other PDCs. The Kavalue of KlPDC for pyruvate istwofold...
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Báo cáo Y học: A single charged surface residue modifies the activity of ikitoxin, a beta-type Na+ channel toxin from Parabuthus transvaalicus doc
... Hammock11Department of Entomology and Cancer Research Center,2Section of Neurobiology, Physiology and Behavior, and 3Departmentof Chemistry and Superfund Analytical Laboratory, University of California, Davis, ... 2002 The marked differences of in vivo symptoms producedby ikitoxin and birtoxin prompted us to examine the effect of the Gly23 to Glu23 change at the molecular level. The a-helixregion of birtoxin ... on their sequence homology to known toxins(Fig. 4), birtoxin and ikitoxin are expected to bind to voltage-gated Na+channels. This possibility was examinedby measuring the effect of these toxins...
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