... the a7anda3b2 nAChRs (Table 1,Table 2) , with PnIA showing a preference for the a3b2subtype and PnIB a preference for the a7 subtype [55].Interestingly, replacement of the alanine residue in ... W., McIntosh, J.M., Paylor,R., Beaudet, A.L., Collins, A.C. & Marks, M.J. (20 02) Involve-ment of the a3 subunit in central nicotinic binding populations.J. Neurosci. 22 , 25 22 25 29.66. ... binding sites within the same receptor, together with the dominant inhibitory effectobtained by binding of only one antagonist molecule,represents a particular advantage of a-conotoxins. Thesefeatures...