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Ebook Essentials of clinical pathology Part 2

Essentials of Clinical Research - part 1 doc

Essentials of Clinical Research - part 1 doc

... Essentials of Clinical Research Stephen P Glasser Editor Essentials of Clinical Research Editor Stephen P Glasser University of Alabama at Birmingham AL, USA ISBN 97 8 -1 -4 02 0-8 48 5-0 e-ISBN ... 15 9 Part II 11 Research Methods for Genetic Studies Sadeep Shrestha and Donna K Arnett 18 1 12 Research Methods for Pharmacoepidemiology Studies Maribel Salas and Bruno Stricker 2 01 13 ... xv Part I This Part addresses traditional clinical research, beginning with the history of the development of clinical research, to traditional clinical research designs, with a focus on clinical...
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Essentials of Clinical Research - part 2 doc

Essentials of Clinical Research - part 2 doc

... African-American Age 25 –44 45–64 6 5-> Median Income $ Education High School CVD Framingham 24 2,800 73.5 62, 910 5.1 30 20 14 26 ,700 35 22 13 55,300 25 28 48 528 –5 82 13 23 ... 20 03 ;21 (7): 129 1-1 29 8 22 Multiple risk factor intervention trial Risk factor changes and mortality results Multiple Risk Factor Intervention Trial Research Group Jama Sep 24 19 82; 248( 12) :146 5-1 477 ... benefit: a systematic review Jama Nov 20 05 ;29 4(17) :22 0 3 -2 20 9 14 Medical Research Council Streptomycin treatment of pulmonary tuberculosis BMJ 1948;ii:76 9-7 82 15 Reviews of statistical and economic books,...
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Essentials of Clinical Research - part 3 ppt

Essentials of Clinical Research - part 3 ppt

... July 2005; 11(4) :35 3 35 9 52 Institute of Medicine of the National Academies The Future of Drug Safety http://www.nap edu/books/ 030 31 030 45/html/1.html Accessed April 3, 2007 53 Public Health Newswire ... July 17, 2002; 288 (3) :32 1 33 3 Maclure M The case-crossover design: a method for studying transient effects on the risk of acute events Am J Epidemiol Jan 15, 1991; 133 (2):144–1 53 Hallqvist J, Moller ... incidence of gastrointestinal events reported higher percentage of incident myocardial infarction in the arm of rofecoxib compared to naproxen during a median follow-up of months ,33 ,34 which questioned...
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Essentials of Clinical Research - part 4 potx

Essentials of Clinical Research - part 4 potx

... 2001, 14; 546 Change in Variables -1 -2 -3 -4 -5 -6 -7 SBP DBP MBP HR PP Fig 7.2 Change during placebo vs no therapy25 Mechanism of the Placebo Effect Much has been discussed about the mechanism of ... regulation of prescription drug advertising and promotion JAMA Nov 14, 1990; 2 64( 18): 240 9– 241 5 40 21 CFR Part 310 section 502(a) of the Food and Drug Administration Modernization Act of 1997 (Modernization ... through β-lipotropin with the regulation of the hypothalamus-hypophysis-adrenal axis There is no understanding of the exact link between the opioid-antiopioid and β-lipotropin systems of neuroendocrine...
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Essentials of Clinical Research - part 5 docx

Essentials of Clinical Research - part 5 docx

... 771 309 850 406 2, 257 5, 217 55 7 707 277 724 354 2,038 4, 657 49 44 27 102 85 246 55 3 67 64 32 126 52 219 56 0 Table 10.3 The individual mortality rates the six studies included in the meta-analysis ... Estimate ( 95% CI) 10 OVERALL 1.12 (0.79–1 .57 ) 1.19 (0.67–2.13) 1.16 (0. 75 1.77) 0.64 (0.06–6 .52 ) 2.27 (1.22–4.23) 0.40 (0.01–3.07) 0.97 (0 .50 –1.90) 0.63 (0.40–0.97) 0.97 (0. 65 1. 45) 0. 65 (0. 45 0. 95) ... meta-analysis Raw data Treatment A PLACEBO Study Total no of patients No dead No alive Total no of patients No dead No alive Total 6 15 758 317 832 810 2,267 5, 599 56 6 714 290 730 7 25 2,021 5, 046...
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Essentials of Clinical Research - part 6 ppsx

Essentials of Clinical Research - part 6 ppsx

... 1, 1992; 69 (6) :68 1 68 6 Oxman AD Meta-statistics: help or hindrance? ACP J Club 1993 Goodman SN Have you ever meta-analysis you didn’t like? Ann Intern Med Feb 1, 1991; 114(3):244–2 46 Pearson ... Med J 1904; 3:1243–12 46 Beecher HK The powerful placebo J Am Med Assoc Dec 24, 1955; 159(17): 160 2– 160 6 Glass G Primary, secondary and meta-analysis of research Educ Res 19 76; 5:3–8 Petitti DB Approaches ... systematic review of randomised controlled trials BMJ Dec 20, 2003; 327(7429):1459–1 461 Part II This Part deals with some of the newer approaches in clinical research, specifically research methods...
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Essentials of Clinical Research - part 7 ppt

Essentials of Clinical Research - part 7 ppt

... = 0. 474 Kappa = (0 .76 − 0. 474 )/(1− 0. 474 ) = 0.54 Fig 14.2 An example of the use of the kappa statistic index of suspicion is influenced by the prevalence of the disease in the population of patients ... activity usually proceeds through a series of ‘plan-do-study-act’ cycles These cycles emphasize measuring the process of clinical care delivery at the level of the clinical microsystem, which has been ... before recruitment begins .77 The ICJME includes interventions focusing on process -of- care within the rubric of clinical trials Trial registries guard against the well-recognized bias that negative...
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Essentials of Clinical Research - part 8 ppsx

Essentials of Clinical Research - part 8 ppsx

... probability of occurring (i.e 80 % or 0 .8) The odds of its occurring is 0 .8/ 10 .8 or 4:1 Odds then, are a ratio of probabilities Note that an odds ratio (often used in the analysis of clinical trials) ... Fagan8) 256 S.P Glasser Table 14.5 Calcium Scores: Se, Sp, PPV and NPV CAC Se % Sp % PPV % NPV % Age 40 to 49 100 300 88 47 18 61 94 97 17 42 60 98 95 93 Age 60 to 69 100 26 41 100 300 74 81 67 86 ... substantial degree of controversy about the utility or misuse of p-values as a measure of meaning ,8 10 but the key idea is that some test statistic, perhaps Z or t, which is often the ratio of some effect...
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Essentials of Clinical Research - part 9 doc

Essentials of Clinical Research - part 9 doc

... degree of correlation, adapted to the nature of data The rate of change of one variable tied to the rate of change of another is known as a slope The correlation coefficient and the slope of the ... the nominal p-value of assessing the strength of this association is 0.001, because of the exploratory nature of the analysis we encourage caution in the interpretation of this p-value and encourage ... functions of one another, and a significant correlation is the same as a significant regression You may have heard of a concept called the r-squared We talk of r-squared as the percent of the variation...
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Essentials of Clinical Research - part 10 pptx

Essentials of Clinical Research - part 10 pptx

... conditioning 123 clinical microsystem 225, 229, 230, 244 clinical pharmacology 80, 89, 101 , 205 clinical trial 4–6, 8, 10, 14, 21, 29–60, 66, 67, 76, 77, 79, 81–85, 87, 90, 99, 102 , 103 , 105 , 108 , 109 , 115–117, ... Types of NIH Research Funding There are a number of types of NIH research funding, but of most relevance to clinical research are: Grant (investigator initiated) Cooperative agreement (NIH is a partner; ... professional effort • must engage in patient-oriented research • must serve as a mentor to developing patient-oriented researchers • salary pro-rated (up to maximum rate) • Nearly all ICs participate...
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Ebook Atlas of anatomic pathology Part 1

Ebook Atlas of anatomic pathology Part 1

... (ed.), Atlas of Mediastinal Pathology, Atlas of Anatomic Pathology, DOI 10 .10 07/978 -1- 4939-2674-9_2, © Springer Science+Business Media, LLC 2 015 19 20 Table 2 .1 Current histologic classifications of ... College of Wisconsin Milwaukee, Wisconsin USA Atlas of Anatomic Pathology ISBN 978 -1- 4939-2673-2 ISBN 978 -1- 4939-2674-9 DOI 10 .10 07/978 -1- 4939-2674-9 (eBook) Library of Congress Control Number: 2 015 9 413 33 ... Atlas of Anatomic Pathology Series Editor Liang Cheng For further volumes: http://www.springer.com/series /10 144 Saul Suster Atlas of Mediastinal Pathology Saul Suster, MD Department of Pathology...
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Ebook Essentials of pharmaceutical chemistry (3rd edition) Part 2

Ebook Essentials of pharmaceutical chemistry (3rd edition) Part 2

... 0. 025 d2A/dk2 Ϫ0. 025 25 1 Ϫ0.05 Ϫ0.075 26 3 Ϫ0.1 23 0 25 7 Ϫ0. 125 23 5 24 0 24 5 25 0 25 5 26 0 Wavelength (nm) 26 5 27 0 27 5 28 0 Figure 7.19 D2 spectra from assay of Ephedrine Elixir BP Quantitative analysis ... 10 12 1 .20 ϫ 106 1 .24 ϫ 104 Inner electron transitions Ultraviolet 10–8 1 02 Å 108 3.00 ϫ 1010 1 .20 ϫ 104 1 .24 ϫ 1 02 Visible 10–6 lm 106 3.00 ϫ 108 1 .20 ϫ 1 02 1 .24 1 .20 1 .24 ϫ 10 2 1 .24 ϫ 10–4 12 ... spectra of authentic samples of a drug are published in the BP to verify the identity of unknown samples 25 4 180 Essentials of pharmaceutical chemistry 26 0 0.075 24 8 0.05 0. 025 d2A/dk2 Ϫ0. 025 25 1...
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Ebook Fundamentals of renal pathology (2nd edition) Part 2

Ebook Fundamentals of renal pathology (2nd edition) Part 2

... Opin Nephrol Hypertens 22 :26 6 27 2 17 Marcantoni C, Ma L-J, Federspiel C, Fogo AB (20 02) Hypertensive nephrosclerosis in African-Americans vs Caucasians Kidney Int 62: 1 72 180 18 Agodoa LY, Appel ... taken not A.B Fogo et al., Fundamentals of Renal Pathology, DOI 10.1007/978-3-6 42- 39080-7_ 12, © Springer-Verlag Berlin Heidelberg 20 14 143 144 12 Diabetic Nephropathy Fig 12. 1 Glomerulus from patient ... 39:1569–1576 11 Østerby R (1997) Renal changes in the diabetic kidney Nephrol Dial Transplant 12: 128 2– 128 3 12 Østerby R, Hartmann A, Bangstad HJ (20 02) Structural changes in renal arterioles in type...
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