Regulation and function of the novel candidate tumor suppressor gene dlec1 in the HCT116 colorectal cancer cell line
The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... on the role of the retinoblastoma gene family in cell cycle regulation and tumor suppression The pRb Cell Cycle Control Pathway: Components and the Cancer Connection The retinoblastoma protein, ... over-expression of D-type cyclins, mutations rendering Cdk4 The Retinoblastoma Gene Family 185 Fig The p16INK4A -pRb and the p19ARF -p53 pathway involved in cell cycle progression and tumorigenesis Components ... will be used The Retinoblastoma Gene Family 187 The Retinoblastoma Gene Family 4.1 Rb Gene Family Members The retinoblastoma gene family comprises, besides Rb, the structurally and functionally...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... PDZ -domain- containing (FRMPD2) [8] and Ras guanine exchange factor (RasGEF) veryKIND (v-KIND, or kinase noncatalytic C-lobe domain containing 1) [9] The KIND domain in these proteins is localized to the ... determined the structural and functional properties of the protein protein interaction between v-KIND and MAP2 We defined the binding core regions for the v-KIND–MAP2 interaction and showed that the ... both KIND1 and KIND2; DRasN, deletion of RasN; DGEF, deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 domain (B) KIND2 domain anchors v-KIND to dendrites Flag-tagged v-KIND, DKIND1, DKIND2,...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
... C An et al Manduca sexta Spatzle ¨ Introduction A prominent feature of the innate immune systems of insects is the activation of serine proteinase cascade pathways in hemolymph, which function ... gene In the clade including Spatzle- 1, the branch lengths are noticeably longer and ¨ the bootstrap values are lower than in the other clades containing Spatzle- 2 to Spatzle- 6, indicating a lower ... cleavage of proSpatzle- 1A after ¨ incubation with the M sexta clip-domain serine proteinases HP6 or proPO-activating proteinase-1 (data A not shown) In the absence of b-mercaptoethanol, Spatzle- C108...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
... (2 010 ) 2 611 –2627 ª 2 010 The Authors Journal compilation ª 2 010 FEBS A B Mantsyzov et al 10 11 12 13 14 15 16 17 domain of release factor eRF1 functions in stop codon recognition RNA 6, 12 36 12 47 ... = 10 8 (s )1) Dyy = 10 8 (s )1) Dzz = 10 8 (s )1) s1 = (4Dxx + Dyy + Dzz) )1 (ns) s2 = (Dxx + 4Dyy + Dzz) )1 (ns) s3 = (Dxx + Dyy + 4Dzz) )1 (ns) 0 .10 2 0 .12 5 0 .14 0 14 .86 13 .48 12 . 71 0 .10 1 0 .12 8 0 .13 9 14 .90 ... polypeptide chain factors, eukaryotic class polypeptide chain release factor (eRF1) and eukaryotic class polypeptide chain release factor (eRF3) The major functions of eRF1 include recognition of each of...
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Báo cáo khoa học: Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways doc
... Attenuation of LXF-289 cell proliferation by ATP is mediated by the activation of the MEK ⁄ ERK1 ⁄ 2, PI3K and p38 MAPK pathways Activation and translocation of the transcription factors NF -jB1 (p50) and ... Table Inhibition of proliferation of LXF-289 lung tumor cells Effects of signaling pathway inhibitors on ATP-inhibited proliferation (A) and of basal proliferation (B) of LXF-289 lung tumor cells ... and ADP in the inhibition of LXF-289 cell proliferation Cell cycle analysis revealed that inhibition of proliferation of LXF-289 cells by ATP and ADP was mediated by retardation of cell cycle...
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Báo cáo khoa học: Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2 pdf
... Lys282 and Arg315 are involved in catalysis The alignment of the small CMLEs from different members of the Rhizobiales with these sequences demonstrated that in A radiobacter S2 (and the other ... CMLE1s from members of the Rhizobiales, such as ArCMLE1 and AtCMLE1, are significantly shorter than the isofunctional enzymes from other bacteria (Fig 2) Expression of ArCMLE1 Comparison of the sequence ... pJOE3075 pETS2-X-II Expression plasmid with a rhamnose-dependent promoter Expression of pcaH2G2 from Agrobacterium radiobacter S2 under the control of the T7 promoter pcaG1 and pcaB 1S2 from A radiobacter...
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structure and function of the arabic verb
... STRUCTURE AND FUNCTION OF THE ARABIC VERB Structure and Function of the Arabic Verb is a corpus-based study that unveils the morpho-syntax and the semantics of the Arabic verb Approaches to verbal ... very indicative, in our opinion, of the adequacy and the basis of this orientation, on the one hand, and the destiny of linguistics, on the other hand Of course, these implications might be too ... on the one hand, and their semantic interpretations, on the other hand VERBAL FORMS, CLAUSES, AND METHODOLOGY This chapter focuses, in particular, on the status and characteristics of these verbal...
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Báo cáo toán học: "Iodine Alters Gene Expression in the MCF7 Breast Cancer Cell Line: Evidence for an Anti-Estrogen Effect of Iodine" doc
... Unveiling iodine’s mechanism of action is of crucial importance Verifying the protective effects of iodine in breast cancer pathways will improve our understanding of breast cancer physiology and ... significant increase in mRNA levels (Figures 2B and C) Discussion As the body of evidence builds, the importance of iodine on the maintenance of healthy breast tissue and its role in carcinogenesis ... our hypothesis, we analyzed the effects of Lugol’s iodine solution (5% I2, 10% KI) on global gene expression in the estrogen responsive MCF-7 breast cancer cell line Analysis of the gene expression...
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Báo cáo y học: "p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis" ppsx
... with mutations was higher in the FLS than in matched synovium This is most probably because the cells bearing mutations in the intact tissue (synoviocytes in the intimal lining) represent only about ... between mutations and the synovial invasion has not been systematically examined In the present study, we first examined paired samples of synoviocytes isolated from the erosive front of synovium and ... number of mutations, p53 cDNA subclones from FLS derived from erosion sites and non -erosion sites were examined Ten erosion FLS lines and nine non -erosion FLS lines were established from nine patients...
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Báo cáo y học: "Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the protein" ppsx
... rapidly than broadly expressed ones [5-7] We have studied the relationship between the phyletic age of a protein and its expression profile, and related this to the function of the protein The ... analysis FuncFunctional File usedof of thethe proteins analysis analysis Phyletic Additionalforof of the proteins usedused used thethe The sequences the the analysis Acknowledgements We thank Eric ... specificity is accounted for by the age of the gene The relationship between phyletic age and tissue specificity is not explained by a gene' s function (test statistic 339.1, p < 0.0001), nor is the...
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EXPRESSION AND FUNCTION OF THE PRL FAMILY OF PROTEIN TYROSINE PHOSPHATASE
... transcription factor function The combined results of these studies have expanded our current understanding of the expression and function of the PRL family of enzymes as well as of the role these important ... Research Integrity and Copyright Disclaimer Title of Thesis/Dissertation: Expression and Function of the PRL Family of Protein Tyrosine Phosphatase For the degree of Doctor of Philosophy Choose ... 3D) and kidney (Figure 3F) Figure Moderate expression of PRL- 1 mRNA and strong expression of PRL- 2 mRNA in the glandular epithelia of the prostate (A,B), urothelia of the bladder (C,D), and glomeruli...
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Regulation and functional analysis of the tumor suppressor gene product, p53
... synthesize first 29 strand cDNA as well as whole p53 gene The 5’ end of the forward primer starts from the start codon of p53 gene and in case of reverse primer the 5’ end starts just after the ... Regulation of p53 dependent DNA-repair target gene promoters 60 by p53Pro and p53Arg variants VI 3.2.2.1 Expression of Gadd45 promoter in presence of either p53Pro 60 or p53Arg 3.2.2.2 Expression of p53R2 ... 1992) Because of these properties, p53 gene is considered as a “guardian of the genome” p53 protein lies at the heart of stress response pathways that prevent the growth and survival of potentially...
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Regulation and function of the novel candidate tumor suppressor gene dlec1 in the HCT116 colorectal cancer cell line
... the siRNA sequence that is most effective in knocking down DLEC1 in HCT116 cell line We then knocked down DLEC1 in the HCT116 cell line using this siRNA 72 hours after the transfection, the cells ... that it was a candidate tumor suppressor gene The over-expression of DLEC1 in hepatocellular carcinoma (HCC) cell lines such as HepG2 and SK-Hep-1 resulted in the inhibition of cell proliferation, ... reduction in cell size and G1 cell cycle arrest (Qiu et al., 2008) In this study, we further validated the tumor suppressing properties of DLEC1 in the HCT116 cell line The cells were subjected to DLEC1...
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Từ khóa: anatomy and function of the heart valvesanalysis and function of the elements contained in sentences and clausesassembly and function of the signal recognition particle from archaeaheart muscle the heart as a pump and function of the heart valvesreproductive and hormonal functions of the male and function of the pineal glandcloning sequencing and expression of a novel goose type lysozyme gene with chitinase ra chic activity from the moderately thermophilic bacterium ralstonia sp a 471anatomy innervation and function of the orbicularis oculi musclewhat is the function of the transport layer and which protocols reside therewhat is the purpose and function of network protocol analyserthe structure and function of complex networksthe structure and function of complex networks pdfthe structure and function of complex networks bibtexnewman m 2003 the structure and function of complex networksthe structure and function of complex networks 中文newman mej the structure and function of complex networksNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngThơ nôm tứ tuyệt trào phúng hồ xuân hươngQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)MÔN TRUYỀN THÔNG MARKETING TÍCH HỢP