Novel biodegradable cationic core shell nanoparticles for codelivery of drug and DNA 2

... exhibit a number of advantages over other forms of drug carriers because of their core- shell structure, low CMC and targeting ability 2. 1.4.1 Core of polymeric micelles as a reservoir for hydrophobic ... structure of the drug and polymer, temperature and pH For example, an increase in the length of a hydrophobic segment of polymer facilitates the entrapment of a hydrophobic drug in the core [Torchilin ... interact and associate to form the core of micelles while the hydrophilic segments arrange towards the aqueous phase to form the shell In the case of the oil-in-water emulsion method, a drug and a...

Novel biodegradable cationic core shell nanoparticles for codelivery of drug and DNA chapter 5 conclusions and recommendations

... the drug and the core- forming segment cholesterol The drug- loaded micelles had suitable size for in vivo application and high zeta potential for DNA binding 5. 1.4 DNA binding ability 182 The DNA ... size of about 10 to 20 nm However, the conjugation of PEG could improve the stability of the micelles, which were designed for systemic delivery of drug and/ or gene 181 5. 1.3 Encapsulation of drug ... conditions, and they had a very stable coreshell structure because of the rigid chemical structure of the core- forming segment cholesterol The TEM scans of the micelles also evidenced the formation of...

Novel biodegradable cationic core shell nanoparticles for codelivery of drug and DNA 4

... in Figure 4. 31 and Figure 4. 32 From Figure 4. 31, the CMC (I1/I3) of PEG5000-P(MDS-co-CES) in deionized water, the acetate buffer (0.02M) with pH of 5.6 and 4. 6 was 42 .7, 74. 7 and 74. 3 mg/L respectively ... encapsulation efficiency of indomethacin was 44 .8%, 48 .4% and 58.2%, and the drug loading was 10.6%, 11 .4% and 13 .4% when the micelles were fabricated by dialysis against deionized water and 0.02M sodium ... with pH of 5.6 and 4. 6 respectively Similarly, in the formulation of polymer to drug weight ratio of 3:1 (15 mg to mg), the encapsulation efficiency was 25 .4% , 21.0% and 29 .4% , and the drug loading...

Novel biodegradable cationic core shell nanoparticles for codelivery of drug and DNA 3

... set at 4.5 nm The ratios of the peak intensities at 33 8 nm and 33 3 nm (I 338 /I 333 ) from the excitation spectra and I3 (the third peak at 38 5nm)/I1 (the first peak at 48 37 4nm) from the emission ... emission spectra (λex =33 9 nm) of pyrene and the I 338 /I 333 ratio from the excitation spectra (λem =39 5nm) of pyrene change with changing the polarity of the microenvironment of pyrene [Jones M-C., ... level was calculated as the ratio of loaded drug mass to the total mass of polymer and loaded drug 3. 5 Binding of DNA with blank and drug- loaded polymeric micelles 3. 5.1 Materials Agarose, biological...

Novel biodegradable cationic core shell nanoparticles for codelivery of drug and DNA 1

... ability of the blank and drug- loaded core- shell nanoparticles, and structural integrity of core- shell nanoparticles during the DNA binding process, • Testing cytotoxicity of the core- shell nanoparticles ... charged shell for DNA binding By using this system, codelivery of DNA and drug can be achieved In addition, due to the unique core- shell structure, it is expected that the stability of the micelle /DNA ... polymers and utilizing these polymers to fabricate cationic core- shell nanoparticles (i.e micelles) for codelivery of drugs and genes, • Pegylating the amphiphilic polymers using PEG of various...

Báo cáo hóa học: " CdSe/TiO2 core-shell nanoparticles produced in AOT reverse micelles: applications in pollutant photodegradation using visible light" doc

... this article as: Fontes Garcia et al.: CdSe/TiO2 core-shell nanoparticles produced in AOT reverse micelles: applications in pollutant photodegradation using visible light Nanoscale Research Letters ... CdSe and TiO2 in the prepared nanoparticles This effect has been reported in the photoreduction of methyl viologen by CdSe and TiO nanoparticles confined in the aqueous pools of AOT reversed micelles ... Figure 4, the photodegradation of MB effected by the prepared CdSe/TiO2 core shell nanoparticles is shown The fraction of the remaining MB in each irradiation time is obtained by subtracting the background...

Báo cáo hóa học: " Formation of PbSe/CdSe Core/Shell Nanocrystals for Stable Near-Infrared High Photoluminescence Emission" docx

... shifts during the formation of CdSe shells were calculated, and they exhibited a good ﬁt to the experimental data The stability of PbSe QDs was dramatically improved by the formation of CdSe shells ... photoluminescence spectra of the PbSe/CdSe QDs upon the series growth of three monolayers of CdSe shells on the 4.8 nm PbSe cores The thickness of each shell is 0.35 nm A consistent red shift of the peak wavelength ... of transmission coefﬁcients of electron and hole From the energy levels shown in Fig [16–18], the expansion probability of electron is bigger than that of hole because of the lower barriers of...

báo cáo khoa học: "Cationic nanoparticles for delivery of amphotericin B: preparation, characterization and activity in vitro" potx

... outstanding anti-infective properties [18] Both amphotericin B and miconazole self-assemble and solubilize at hydrophobic sites of DODAB or DHP bilayer fragments in water solution exhibiting in ... fungus viability For final coverage with polylysines (PL) of increasing molecular weight at mg/mL PL, there was an increase in the final zeta-potential modulus and a larger loss of viability (Table ... CMC/PDDA (C) and DODAB/ AmB/CMC/PDDA (D) interacted for h before dilution and plating on agar of 0.1 mL of the diluted mixture (1:1000 dilution) 1:10 either in IGP or in Milli-Q water yielding × 106...

Organic phase fabrication of core shell materials for the encapsulation of biomolecules

... resulting in fabrication of novel core- shell materials The objective of this work is therefore to study and perform the organic phase fabrication of core- shell materials for encapsulation of biomolecules ... for organic phase fabrication of core- shell materials; 3) Organic phase fabrication of hydrogel core- shell materials; 4) Characterization of fabricated core- shell materials 5) Encapsulation of ... Objective The objective of this work is to perform and study the organic phase fabrication of core- shell materials for the encapsulation of biomolecules 3.2 Specific Aims To achieve the main objective...

Báo cáo hóa học: " Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution" docx

... ligand influence nanoparticle tumor localization or uptake? Trends Biotechnol 2008, 26:552 doi:10.1186/1556-276X-6-563 Cite this article as: Hou et al.: Both FA- and mPEG-conjugated chitosan nanoparticles ... mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution Nanoscale Research Letters 2011 6:563 Submit your manuscript to a journal and beneﬁt from: Convenient ... tumor The result also shows that both FA-NPs and mPEG-FA-NPs (Figure 7B b, d) were more fluorescent than NPs without FA-modified (Figure 7B, a, c), suggesting that the accumulations of both FA-NPs...

Magnetic chitosan nanoparticles for removal of Cr(VI) from aqueous solution

... and the Cr(VI) concentrations at any time t, respectively; V (L) is the volume of the Cr(VI) solution; and m (g) is the mass of the magnetic chitosan nanoparticles Samples of the Cr(VI) solution ... sorption experiments were performed by batch method Samples of 0.1 g of magnetic chitosan nanoparticles were equilibrated with 50 mL of solution containing various amount of Cr(VI) The pH value X-ray ... Characterization of magnetic chitosan nanoparticles TEM and SEM micrograph of magnetic chitosan particles provides information on their size and morphology It can be observed from Fig that the magnetic...

Báo cáo y học: "Novel therapies for treatment of gout and hyperuricemia" pot

... approximately half of febuxostat-treated patients with tophi can achieve elimination of tophi by years, and approximately 70% by years [49] Quality of life parameters have been favorably impacted by extended ... highly antigenic and has a plasma half-life of 18 to 24 hours [52] Efficacy, tolerability, and sustainability of rasburicase treatment beyond to 12 months appear to be poor for treatment of refractory ... into a collective of favorable outcomes for both control of gouty inflammation and management of hyperuricemia, as well as improved outcomes of gout- related quality of life and co-morbidities...

Báo cáo y học: "Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts" pps

... = 0.35) Rapamycin Pharmacokinetics Measurement of rapamycin levels in vein grafts demonstrated the presence of drug in vein grafts at days (after the vein being immersed in rapamycin-loaded NPs ... release of rapamycin in the vein until day 21 after grafting which suggests that RPLGA NPs delivery system may be applied to human beings clinically The bio-absorption time of PLGA in the body can ... stage intimal hyperplasia of vein graft was inhibited significently The study of Thirumaran and colleagues [21] have shown that periadventitial application of rapamycin-eluting polyvinyl alcohol...

Surface modification of ferromagnetic nanoparticles for separation of toxic heavy metals and environmental applications

... SURFACE MODIFICATION OF FERROMAGNETIC NANOPARTICLES FOR SEPARATION OF TOXIC HEAVY METALS AND ENVIRONMENTAL APPLICATIONS ZAYED BIN ZAKIR SHAWON B.Sc (Chemical ... cost of separation of detrimental pollutants like heavy metals Recently, scientists have focused on the development of the nanomaterials as adsorbents for the separations of biomolecules, heavy metals, ... to remove toxic heavy metals from wastewater Ferromagnetic nanoparticles are superparamagnetic and offer very fascinating physical and chemical properties The adsorption capability of these nanoadsorbents...

Surface functionalized magnetic nanoparticles for separation of chiral biomolecules, pharmaceuticals and endocrine disrupting compounds

... of magnetic separation, reviews previous work on magnetic separation and introduces the recent progress in separation of chiral biomolecules, pharmaceuticals, endocrine disrupting compounds and ... SURFACE FUNCTIONALIZED MAGNETIC NANOPARTICLES FOR SEPARATION OF CHIRAL BIOMOLECULES, PHARMACEUTICALS AND ENDOCRINE DISRUPTING COMPOUNDS SUDIPA GHOSH B.Sc (Chemical ... results of pharmaceuticals and endocrine disrupting compounds are presented Effect of operating conditions, kinetics of sorption separation and desorption conditions of pharmaceuticals and endocrine...

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