Study of the associated proteins of STAT3 and characterization of their functions roles of GRIM 19 and PIN1 in the regulation of STAT3 activity

... STUDY OF THE ASSOCIATED PROTEINS OF STAT3 AND CHARACTERIZATION OF THEIR FUNCTIONS: ROLES OF GRIM- 19 AND PIN1 IN THE REGULATION OF STAT3 ACTIVITY LUFEI CHENGCHEN B Sc (Hons), NUS A THESIS ... fold of human Pin1 37 Figure 3.1 Interaction of Stat3 and GRIM- 19 71 Figure 3.2 Association of endogenous Stat3 and GRIM- 19 75 Figure 3.3 Lack of interaction between GRIM- 19 and other STAT proteins ... GRIM- 19 in mitochondria 33 1.8.3 GRIM- 19 interacting proteins 34 1.9 Peptidyl-prolyl isomerase Pin1 1.9.1 Isolation and activity characterization of Pin1 1.10 Biological functions of Pin1 1.10.1 Pin1...

Báo cáo khoa học: cGMP and glutathione-conjugate transport in human erythrocytes The roles of the multidrug resistance-associated proteins, MRP1, MRP4 and MRP5 pot

... and that vincristine inhibits the high affinity DNP-SG transport in the presence but not in the absence of GSH [12,45,46] Thus the effect of vincristine on the cGMP uptake was also tested in the ... these and cGMP block low affinity [3H]DNPSG transport in human erythrocytes and so the low affinity transport of DNP-SG and the transport of cGMP may be mediated by one and the same transporter The ... phosphodiesterase inhibitor, inhibited transport All of these effects are compatible with cGMP transport by a member of the MRP family Immunodetection of MRP4 and MRP5 proteins in human erythrocytes and COR-L23/R...

Báo cáo khoa học: Accessory proteins functioning selectively and pleiotropically in the biosynthesis of [NiFe] hydrogenases in Thiocapsa roseopersicina docx

... to identify the intermediates in the various T roseopersicina mutants are in progress In summary, HupK is selectively involved in the biosynthesis of the various [NiFe] hydrogenases In contrast, ... HupK protein Thirty one amino acid residues in the truncated HupK originated from the N-terminus, 37 aa from the C-terminus of the protein and 13 aa came from the multiple cloning site of the pK18mobsacB ... of the mutant strains resulted in the identiﬁcation of one locus containing the hupK-hypC1DE accessory genes and another one, where the hypC2 and hynD genes were found The organization of the accessory...

Báo cáo khoa học: Involvement of NF-jB subunit p65 and retinoic acid receptors, RARa and RXRa, in transcriptional regulation of the human GnRH II gene pot

... retinoic acid (RA) treatments on GnRH II promoter activity To investigate the in vivo effect of RARa and RXR on the transcriptional regulation of the hGnRH II gene, the expression vector of human ... on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of RARa and RXRa with their ligands, ATRA and 9-cisRA, on the promoter activity of the hGnRH II gene in TE671 ... on the GnRH II gene, has also been reported [6] The present study aimed to deﬁne the cis-acting element and investigate the protein factors involved in regulation of the hGnRH II gene in TE61 and...

Báo cáo y học: " A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytes" pot

... 5'-TGTTTGGAGACTGTGTACAAGGCG-3', hTERT sense, 5'-TGTTTCTGGATTTGCAGGTG-3' and antisense, 5'-GTTCTTGGCTTTCAGGATGG-3', Pot1 sense, 5'TGGGTATTGTACCCCTCCAA-3' and antisense, 5'-GATGAAGCATTCCAACCACGG-3' TRF1 ... Collectively, these results validate a balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and POT1 in normal, activated as well as in HTLV-1 infected and in Tax-expressing ... sense,5'-GCTGTTTGTATGGAAAATGGC-3' and antisense: 5'CCGCTGCCTTCATTAGAAAG-3', TRF2 sense, 5'-GACCTTCCAGCAGAAGATGC-3' and antisense, 5'-GTTGGAGGATTCCGTAGCTG-3' The thermal cycling conditions consisted...

Role of calpain and cofilin in apoptosis regulation

... blocking cofilin translocation Figure 5.4.3 Cofilin S3D blocks translocation of endogenous cofilin Figure 5.5 Mitochondrial-localised cofilin induces apoptosis Figure 5.6.1 Cofilin1 5-166, cofilin1 5-30/106-166 ... Silencing of cofilin expression using cofilin siRNA Figure 5.2.2 Lack of cytochrome c release and apoptotic morphology in cofilin knockdown cells Figure 5.2.3 Depletion of endogenous cofilin protein inhibits ... localisation of cofilin is independent on its actin-binding activity Figure 5.7.2 Mitochondrial-localised cofilin mutant-induced apoptosis is dependent on the actin-binding domain Figure 5.7.3 Cofilin...

báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx

... (dashed line) initial AOC levels with Cumulative survival of patients with Alzheimer's disease with low (solid line) and high (dashed line) initial AOC levels Low and high AOC levels were defined ... and of its capacity to cope with inflammatory and oxidative insults The lower levels of peripheral AOC observed in AD patients is also consistent with the finding of lower oxidative resistance of ... measuring their peripheral AOC and to examine the association between AOC levels, the severity of cognitive impairment, and patient survival We found that serum AOC is reduced in AD patients and is...

Báo cáo y học: "Factors associated with septic shock and mortality in generalized peritonitis: comparison between community-acquired and postoperative peritonitis" doc

... comparable between these two groups In the subgroup of patients with peritonitis with septic shock, biliary origin was independently associated with increased mortality Yeast in peritoneal fluid of postoperative ... Intra-peritoneal yeasts and Enterococci were associated with septic shock in the subgroup of patients with community-acquired peritonitis Yeasts were also associated with increased mortality in postoperative ... fluid were independent risk factors of septic shock Incidence of septic shock and mortality rate were no different between patients with community-acquired and postoperative peritonitis Intra-peritoneal...

Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"

... history of diabetes and higher body mass indexes During the five years of follow-up, 1 02 (15 .2% ) patients in the normoglycaemia group and 66 (18.3%) patients in the hyperglycaemia group died There ... inclusion in the study We excluded 21 1 patients who refused to participate in the study, 20 3 patients due to terminal illness, and another 29 patients who were receiving corticosteroid treatment Of the ... RF: Inflammatory status and insulin resistance Curr Opin Clin Nutr Metab Care 20 02, 5:551-559 14 Marette A: Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings...

Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot

... conformational ¯exibility We not consider the rheomorphic state of a Caseins, synucleins and tau as rheomorphic proteins The ROA data clearly show the caseins, synucleins and tau to have similar ... caseins, synucleins and tau (Eur J Biochem 269) 155 CONCLUSIONS This study has shown that the casein milk proteins, the brain proteins synuclein and tau, as well as mutants of a- synuclein and tau associated ... DSC, of caseins, synucleins and tau, together with several mutants of a- synuclein and tau that cause neurodegenerative diseases The ROA spectra of all these proteins are very similar to those of...

Báo cáo y học: "Correction: A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes" pdf

... Gornik et al Critical Care 20 10, 14:444 http://ccforum.com/content/14/5/444 Page of 22 07 patients admitted to medical ICU 385 with a history of DM, IFG or IGT 1 822 27 4 died in hospital 1548 screened ... 21 1 refused participation - 20 3 terminally ill - 29 receiving corticosteroids 669 436 NORMOGLYCAEMIA HYPERGLYCAEMIA 76 excluded: - newly diagnosed DM, IGT or IFG 669 360 started follow-up 1 02 ... steroid treatment 193 47 IGF / IFG 33 DM 113 normoglycaemic Figure Flow diagram showing the loss of patients from initial screening to the end of five-year follow-up ...

Báo cáo y học: "Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study" pot

... clinical evaluation of patients, samples and data collection PS participated in the statistical analysis NGQ, IS and EHR did genotyping CRG conceived the study, analyzed and interpreted data, and wrote ... overrepresented among patients who died at 28 or 90 days, and they also predisposed to MODS and ARDS respectively Likewise, 6A was associated with ARDS, and 1A was associated with MODS By contrast, 6A3 and ... with CAP Haplotypes 6A1 2, 1A1 0 and 6A to 1A are overrepresented among patients who died at 28 or 90 days By contrast, 6A3 and 6A3 to 1A1 are protective against 28-day and 90-day mortality Additional...

X ray crystallographic study of yeast dcp1 and dcp2 proteins insights into the mechanism and regulation of eukaryotic mRNA decapping

... out by the Dcp1- Dcp2 holoenzyme Dcp2 is a Nudix pyrophosphatase and Dcp1 stimulates the activity of Dcp2 The crystal structures of yeast Dcp1 and Dcp2 proteins are presented in this study The structure ... function and regulation of the decapping proteins Dcp1 and Dcp2 Yet several questions still remain open regarding the decapping complex: 1) What is the structure of the Dcp1 protein and is the prediction ... both yeast and human Dcp2 proteins, the efficiency of decapping is in correlation with the length of the substrate It is hypothesized that the special separation of the RNA binding site and the decapping...

The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy

... THE STUDY OF INTERACTIONS OF TRANSMEMBRANE RECEPTORS AND INTRACELLULAR SIGNALING PROTEINS IN LIVE CELLS BY FLUORESCENCE CORRELATION AND CROSS -CORRELATION SPECTROSCOPY LIU PING (M.Sc), CAS A THESIS ... C-terminus domain, to expose binding sites for Src-homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing proteins Adaptor proteins with a SH2-binding domain ... ligands bind to the extracellular domains of two receptor subunits and form a 2:2 complex (42), resulting in activation of the intracellular kinases of the receptors Upon ligand binding, the...

Computational study of therapeutic targets and ADME associated proteins and application in drug design

... process of drug discovery - VI - Computational study of therapeutic targets and ADME- associated proteins and application in drug design List of Tables LIST OF TABLES Table 1-1: A brief history of ... pharmacogenetic prediction of drug responses 159 - VII - Computational study of therapeutic targets and ADME- associated proteins and application in drug design List of Figures LIST OF FIGURES Figure ... guiding the search of druggable proteins 126 5.2.2 Prediction of druggable proteins by a statistical learning method.132 Computational analysis of drug ADME- associated proteins .137 6.1 ADME- associated...

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