Proteomic analysis of airway inflammation in murine asthma models

... protein components of the epithelial lining fluid of the airways and alveoli Distinct change in certain protein levels in BAL fluid has been correlated to allergic airway inflammation Many investigations ... staining for fibronectin 113 27 Representative 2-D gels in chronic asthma model 120 28 Protein grouping using Gene Ontology Annotation 124 29 Interactions between actin binding proteins and actin ... RT-PCR analysis in acute asthma model 96 20 Serum level of OVA-specific IgE in chronic asthma model 106 x 21 Airway responsiveness in chronic asthma model 107 22 H&E staining for airway inflammation...

Báo cáo hóa học: "Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD)" potx

... eradication of inflammatory cells does not automatically lead to an improvement of clinical symptoms in airway diseases such as allergic asthma [66], other features of airway diseases such as hypersecretion ... magnification of 1000× (each group n = animals) Analysis of data The secretory basal and stimulated activity is measured as counts per minute (cpm) Data are presented as ± S.D Statistical analysis was ... secretory activity of the airway under the conditions of chronic airway inflammation have not been established so far With regard to a situation of a lack in valid strategies for hypersecretion therapy...

Báo cáo y học: " Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis" ppsx

... Chronic inflammation can lead to sustained alterations of bone turnover, as typically seen in juxta-articular and periarticular damage of inflamed joints in RA TNF is a proinflammatory cytokine of ... characterized by a hyperplastic synovial membrane invading the subchondral bone (Figure 1) Compartments with different patterns of bone turnover in inflammatory arthritis To assess bone turnover in the ... the inflammatory tissue directly drives osteoclastogenesis, which is a well-known process and involves the expression of TNF by various cells types within inflammatory tissue and of RANKL by T...

A multiplex comparative proteomic analysis of hypoxia influence in the presence and absence of p53 in HCT116 cells

... Other kinases, such as casein kinase I and II, protein kinase A, 38 CDK7, DNA-activated protein kinase, and Jun-NH2 kinase (JNK), also mediate phosphorylation of p53 and play important roles in ... that in turn “protects” radiation-damaged DNA from restoring to an undamaged state Stable DNA damage accumulates and leads to an increased lethality from a given dose of radiation in cells, inducing ... criteria 4.3 Top funcitons and diseases identified by IPA 76 4.4 Tabulation of common proteins regulated in cells under 81 hypoxia in the presence and absence of p53 as well as in the absence of p53...

Báo cáo y học: " Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma" potx

... airway inflammatory diseases Therapeutic targeting of LPA2 may be beneficial in reducing allergic inflammatory responses in airway diseases Competing interests The authors declare that they have ... 279(39):41085-41094 Hashimoto T, Nakano Y, Yamashita M, Fang YI, Ohata H, Momose K: Role of Rho-associated protein kinase and histamine in lysophosphatidic acid- induced airway hyperresponsiveness in guinea pigs ... mediators including lipid mediators play a critical role in the pathogenesis of chronic airway diseases and facilitate the recruitment, activation, and trafficking of inflammatory cells in the airways...

Báo cáo y học: "Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways" ppsx

... affect airway inflammation in the mouse We have previously described a murine model of asthma that includes non-specific AHR and associated eosinophilia in the airways [5] In the present study we ... Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization Am J Respir Crit Care Med 1997, 155:819-825 Hogan SP, Koskinen A and Foster PS Interleukin-5 ... monocyte and lymphocyte numbers in lung tissue (Table 2) This increase in numbers of inflammatory cells was significantly inhibited by Throughout the literature there are reports of various interventions...

Báo cáo y học: " Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-β knock-out mice" doc

... bronchial inflammation and airway hyperreactivity in mice Pharmacology 1997, 55:32-43 Satoh Y, Kasama K, Kuwabara M, Yimin, Diao HY, Nakajima H, Kohanawa M, Minagawa T: Suppression of late asthmatic ... after CpG treatment in a murine model of allergic inflammation Our results indicate that induction of Th1 response by therapy with CpG- ODN is partially dependent on IFN-β, while IFN-β is not an absolute ... containing CpG have the ability of immunomodulation with a downregulation of elevated IgE and eosinophilic inflammation in the airways, both of which are orchestrated by cytokines elaborated by...

Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"

... molecules in the course of hypoxia-induced apoptotic pathways Such analysis of trophoblastic cells will, in the near future, yield insights into the mechanisms of preeclampsia and other hypoxia-related ... and by modulating phosphorylation of JNK In conclusion, various pro- and antiapoptosis-related proteins were expressed in the process of hypoxia-induced apoptosis in the trophoblastic cell line ... gene, but by modulating phosphorylation of JNKs Thus, Bag-1 may inhibit apoptosis by suppressing the expression of Bid and Bad Bag-1 may also enhance apoptosis by inhibiting the expression of Bcl-2...

Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx

... overexpressing a- synuclein A proteomic analysis is expected to identify cellular alterations that are associated with dopamine treatment and modulated by a- synuclein overexpression, without any a priori ... eukaryotic initiation factor 5A (eIF 5A) , parathymosin, L7 ⁄ L12, annexin A2 , annexin A5 , aldolase A, fascin and peroxyredoxin 1] displayed quantitative differences, regardless of whether or not a- synuclein ... above (Tables S2 and S3) In both cases, bioinformatic analysis revealed that the NF-jB pathway could be involved in determining the effects of dopamine treatment and a- synuclein overexpression Accordingly,...

Báo cáo y học: " Candida soluble cell wall β-glucan facilitates ovalbumin-induced allergic airway inflammation in mice: Possible role of antigen-presenting cells" ppt

... lungs Histological findings of hematoxylin and eosin (H&E)-stained Histological findings of hematoxylin and eosin (H&E)stained lungs The groups of mice were intratracheally inoculated with vehicle, ... that a single pulmonary exposure to CSBG induces lung inflammation characterized by the infiltration of inflammatory leukocytes including eosinophils with an enhanced lung expression of proinflammatory ... impacts of nosocomial fungal infection on the induction/aggravation of allergic airway inflammation, particularly in the context of its responsible constituents In the present study, initially, we...

Báo cáo y học: "Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated " ppsx

... reporting an ozone- induced increase in oxidative stress markers in this group of subjects [15,17] In conclusion, the increase in some markers of airway inflammation and/or oxidative stress can be observed ... al.: Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated asthmatics with minimal functional response to ozone Respiratory Research 2010 11:5 Publish ... variability in the magnitude of pulmonary response, both in terms of functional and inflammatory reaction to ozone exposure, with a large proportion of subjects showing no significant change in airway...

Báo cáo y học: " Vascular endothelial growth factor: an angiogenic factor reflecting airway inflammation in healthy smokers and in patients with bronchitis type of chronic obstructive pulmonary disease?" ppsx

... stress and release of inflammatory mediators in the airways of healthy subjects and that these effects can be both acute and chronic [1820] Compared to healthy non -smokers the degree of airway inflammation ... 3: Spearman's rank correlations between VEGF levels in induced sputum and smoking pack-years, airway obstruction, and airway inflammation in asymptomatic and COPD smokers Asymptomatic smokers ... sputum not only in bronchitis type of COPD smokers but also in asymptomatic smokers, may indicate that VEGF plays an important signalling role linking the inflammatory milieu with changes in bronchial...

Báo cáo y học: "Salmeterol plus fluticasone propionate versus fluticasone propionate plus montelukast: a randomised controlled trial investigating the effects on airway inflammation in asthma" pot

... horizontal line represents the median value SFC, salmeterol plus fluticasone propionate; FP/M, fluticasone propionate plus montelukast The primary outcome was the extent of airway inflammation as ... disassociated from eosinophilic airway inflammation [5-7] The residual symptoms and abnormal airway function seen in our patients in the absence of eosinophilic airway inflammation could reflect the effect ... study as well as coordinating and reviewing the manuscript All authors read and approved the final manuscript 13 14 Barnes PJ: The role of inflammation and anti-inflammatory medication in asthma...

Báo cáo y học: " Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD" potx

... may indicate the similar inflammatory response in smokers and exsmokers with COPD, which is associated not only with smoking, but also with systemic inflammation Influence of smoking may explain ... analyse airway inflammatory cell patterns in smokers and ex -smokers with COPD and to compare whether it differs from 'healthy' smokers and neversmokers Also, according to a previous study, showing ... development in the future Conclusion Smokers and ex -smokers with COPD had close to similar number and type of IS inflammatory cells, indicating an ongoing inflammation in proximal airways after smoking...

Báo cáo y học: "Can HRCT be used as a marker of airway remodelling in children with difficult asthma?" docx

... bronchoalveolar lavage and EB as part of their clinical assessment in order to help confirm the diagnosis of asthma and to exclude any other associated abnormalities such as structural airway abnormalities ... study airway wall changes in asthma [5] Bronchial wall thickening (BWT) on HRCT has been shown to be a consistent finding in children with difficult asthma [6] and a relationship between BWT and ... sub-segmental airways A separate score was given to each lobe Scores ranged from to was normal wall thickness, was minimal wall thickening, was bronchial wall thickness half of the diameter of the adjacent...

Xem thêm

Từ khóa: what is the best clinical indicator of airway obstruction in children with asthma stable isotope labeling with amino acids in cell culture based proteomic analysis of ethanol induced protein expression profiles in microglia character analysis of the governess in the turn of the screw an analysis of speech acts in the film platoon analysis of speech act in movie a contrastive analysis of personal pronoun in english and vietnamese recent advances in the exploratory analysis of interregional flows in space and time role of airway surfactant in chronic obstructive pulmonary diseases model for the general analysis of supervisory mechanisms in arms control treaties 01 chromatographic polarographic and ion selective electrodes methods for chemical analysis of groundwater samples in hydrogeological studies analysis of reference tracking in lpni systems analysis of disturbance rejection in lpni systems coarse molecular dynamics analysis of structural transitions in solid materials postmortem dna qc considerations for sequence and dosage analysis of genes implicated in long q a co twin control analysis of military service in vietnam and posttraumatic stress disorder ptsd chuyên đề điện xoay chiều theo dạng Nghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THz Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit ĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDE Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùng Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tin Thơ nôm tứ tuyệt trào phúng hồ xuân hương Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khí Chuong 2 nhận dạng rui ro Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2 Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vật Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘI Chiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015 HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM QUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ