Structural studies of cysteine and serine protease inhibitors towards therapeutic applications

... mechanism of cysteine proteases 14 1.3.3 Inhibitors of Cysteine proteases 16 1.3.4 Endogenous inhibitors: Cystatin superfamily 1.3.5 Synthetic inhibitors of Cysteine proteases 1.4 Serine proteases ... mechanism of Serine proteases 23 1.4.2 Serine protease inhibitors 26 1.4.3 Serpins 27 1.4.4 Canonical serine protease inhibitors 29 1.4.5 Non canonical serine protease inhibitors 31 1.4.6 Synthetic inhibitors ... development of the heart and the brain (Hooper et al, 2005) The projects reported in this thesis are mainly related to serine and cysteine proteases and their inhibitors Serine proteases and Cysteine proteases...

Studies of cobalt and iron oxidesoxyhydroxides nanostructures for electrochemical applications

... STUDIES OF COBALT AND IRON OXIDES/ OXYHYDROXIDES NANOSTRUCTURES FOR ELECTROCHEMICAL APPLICATIONS LEE KIAN KEAT (M Sc., Universiti Teknologi Malaysia) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR ... and Han et al.47 1.5 Properties of cobalt compoundsrelevantto electrochemical applications 1.5.1 Electrochemical capacitance and electrochemistry of cobalt compounds Early electrochemical studies ... patterns of cobalt foil heated at 350 °C for various durations (inset) and the magnified XRD pattern of cobalt foil heated at 350 °C for 24 h, (b) XRD patterns of cobalt foil heated at 450 °C for...

Báo cáo khoa học: Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase doc

... structure of dNK has previously been determined in complexes with substrates and a feedback inhibitor [12,13] It has a structure similar to that of the human dGK and dCK and belongs to a structural ... speciﬁcity of dNK Earlier crystallographic studies of substrates dT and dC and on the structure of the feedback inhibitor complex with dTTP, as well as mutation studies, have established some of the ... positioned to form speciﬁc interactions to the sugar and the base of the substrate The 3¢-oxygen of deoxyribose is hydrogen bonded to Tyr70 and Glu172, and the 5¢-oxygen is hydrogen bonded to Glu52 and...

Báo cáo khoa học: Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding pot

... this study, we describe the structures of two homologues, TKs from B anthracis and B cereus, in complex with substrate dT and phosphate donormimicking dTTP Because of the high sequence identity ... expression and puriﬁcation of human thymidine kinase 1: quaternary structure, stability, and kinetics Protein Expr Purif 47, 506–515 20 Black ME & Hruby DE (1990) Quaternary structure of vaccinia ... anthracis and B cereus The amino-acid sequence identity between the TKs from B anthracis (Ba-TK) and B cereus (Bc-TK) is as high as 96% The sequence identity with human TK1 (hTK1) is 37–38% From...

Báo cáo khoa học: Structural studies of the capsular polysaccharide and lipopolysaccharide O-antigen of Aeromonas salmonicida strain 80204-1 produced under in vitro and in vivo growth conditions docx

... 271) strain 80204-1 produced under in vitro growth conditions on tryptic soy agar (TSA) and in vivo and have demonstrated that their structures are chemically and antigenically distinct from the ... TOF Analysis of the in vivo cultured A salmonicida strain 80204-1 cells In vivo culture was performed using ligated dialysis tubing bags filled with bacterial suspension of A salmonicida strain ... sample of A salmonicida (data not shown) The proposed structure of CPS and O-chain polysaccharide of A salmonicida strain 80204-1 is depicted in Fig The biological significance of these findings...

biochemical and structural studies of escherichia coli leucine-responsive regulatory protein

... Dissertation Topic: Biochemical and Structural Studies of Escherichia coli Leucine-responsive Regulatory Protein Experience 1997-1998 Teaching Assistant Department of Chemistry University of North Carolina, ... Biochemical and structural studies of Escherichia coli Lrp Transcriptional regulation of gene expression is an essential component for the life of any organism For uropathogenic Escherichia coli, ... this protein to understand more about PapI and how to better work with it 19 Purification and Characterization of Lrp and PapI 2.1 Purification and characterization of Lrp 2.1.1 Materials and...

Synthetic and structural studies of copper, gold and palladium heterocyclic carbene complexes

... ferrocene-derivatized carbene and palladium( I) complexes have been very limited In view of the significance of copper, gold and palladium carbene complexes in organic synthesis, materials and medicine, ... enriching the knowledge of copper, gold and palladium NHC complexes, the results of this research will be instructive for mechanistic study and future designs of copper, gold and palladium NHC catalysts ... However, most of these studies were focused on Pd-, Ni-, Ru- and Rh-NHC complexes NHC complexes of copper and gold have been relatively overlooked in spite of the wide use of copper and gold in catalysis,...

$Application of Hydrothermal Reaction to Biodegradability Improvement of Refractory Pollutants: Structural Conversion of Di- and Trichloroacetic Acid to Biodegradable Products$

Application of Hydrothermal Reaction to Biodegradability Improvement of Refractory Pollutants: Structural Conversion of Di- and Trichloroacetic Acid to Biodegradable Products

... results of Figure 1, and 4, CAAs were converted to biodegradable products at the beginning of hydrothermal reaction The production of biodegradable products by structural conversion of CAAs required ... hydrothermal reaction at 250 C and MPa Journal of Water and Environment Technology, Vol.1, No.2, 2003 acid, % of glycolic acid and % of formic acid were detected in The amount of malic acid decreased, and ... and Thus, biodegradability and the total amount of biodegradable substances in products are investigated Figure represents the effect of reaction time on the biodegradability improvement of products...

Báo cáo khoa học: 15 N-Labelled proteins by cell-free protein synthesis Strategies for high-throughput NMR studies of proteins and protein–ligand complexes doc

... information, the protein ligand interaction can be probed by [15N]-HSQC FEBS Journal 273 (2006) 4154 – 4159 ª 2006 The Authors Journal compilation ª 2006 FEBS 4157 15 N-labelled proteins by cell-free ... accelerated studies of proteins by NMR spectroscopy by assigning residue type information to every amide cross-peak observed in [15N]-HSQC spectra We anticipate that high yield cell-free protein synthesis ... preparation of ﬁve samples leads to the assignment of every [15N]-HSQC cross-peak to one of FEBS Journal 273 (2006) 4154 – 4159 ª 2006 The Authors Journal compilation ª 2006 FEBS 4155 15 N-labelled proteins...

Báo cáo khóa học: C-, 15N- and 31P-NMR studies of oxidized and reduced low molecular mass thioredoxin reductase and some mutant proteins docx

... 13C and 15N-NMR signals of FAD bound to wild-type TrxR and mutant proteins in the oxidized and reduced states Chemical shifts of wild-type TrxR (in p.p.m.) Dd (p.p.m.) Atom Oxidized Reduced Oxidized ... reconstituted thioredoxin reductase (TrxR), and of the native mutant protein E159Y in the oxidized and reduced states For comparison the chemical shifts of free FAD and those of other members of the ... nitrogen atom Table 13C and 15N-NMR chemical shifts (in p.p.m.) of avins in solution and FAD bound to wild-type thioredoxin reductase (TrxR) and mutant proteins in the oxidized state Atom Free...

Báo cáo khoa học: Correlation between functional and structural changes of reduced and oxidized trout hemoglobins I and IV at different pHs doc

... order: iron(II)HbIV > met-HbIV > met-HbI > iron(II)-HbI The larger peroxidative activity of iron(II)-HbIV with respect to metHbIV is in line with previous data obtained with human HbA derivatives [7] ... [6] Figure shows the peroxidase activity of iron(II)- and met-forms of HbI and HbIV It is evident that the enzymatic activity decreases according to the order iron(II)-HbIV > met-HbIV > met-HbI ... indicating that tetramers with high-spin ligand water of iron(III) subunits, show the most T-state behavior [38] CD spectra show that iron(II)- and iron(III)-HbI structural features are almost insensitive...

Báo cáo khoa học: Thiamin diphosphate in biological chemistry: analogues of thiamin diphosphate in studies of enzymes and riboswitches pot

... understanding of ThDP-dependent enzymes, as well as studies of thiamin analogues as drug molecules and in the eld of riboswitches Fig Thiamin diphosphate a-carbanion resonance structure) Depending ... in the pyridine series II Synthesis of 2-methyl-3-hydroxyethylpyridine and of the pyridine analogue of thiamine (vitamin B1) J Org Chem 6, 5462 Wooley DW (1950) Pyrithiamine and neopyrithiamine ... Schneider G (1994) Specicity of coenzyme binding in thiamin diphosphate- dependent enzymes crystal-structures of yeast transketolase in complex with analogs of thiamin diphosphate J Biol Chem 269,...

THE STRUCTURAL DESIGN OF TALL AND SPECIAL BUILDINGS doc

... both motions of the pair The vector of the response spectra is calculated as the square root of the sum of the squares (SSRS) of the response spectra for the two different directions, and this vector ... Los Angeles Tall Buildings Structural Design Council 2006 An Alternative Procedure for Seismic Analysis and Design of Tall Buildings Located in the Los Angeles Region Los Angeles Tall Buildings ... representative of the overall loaddeformation behavior of the building and compute a response history using appropriate software (e.g., Hachem, 2004) Dynamic analysis of the oscillator under the design...

Báo cáo khoa học: "Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series" pptx

... chronological order of FDA approval, saquinavir, ritonavir, indinavir, nelfinavir, lopinavir, atazanavir, fosamprenavir (pro-drug of amprenavir, which is no longer available), tipranavir, and darunavir ... ritonavir and one nelfinavir) The case series included more malignancies not associated with HIV or AIDS (ductal carcinoma of the breast, renal cell carcinoma, cholangiocarcinoma, and meningioma), and ... of malignancies treated Nearly all patients in the Plastaras et al study were treated with nelfinavir, three were treated with saquinavir (the oldest available PI), and one was treated with amprenavir...

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