The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
... Accordingly, the great and urgent need presently is to investigate the role of each of the plenitude of genes and proteins important in the progression of cancer NUCLEAR RECEPTORS The nuclear receptors are ... Tan, Shazib Pervaiz, The NR4A orphan nuclear receptors are target genes of the novel drug C1 in cancer cells and potential mediators of drug induced apoptosis (manuscript under preparation) CONFERENCE ... family of receptors This study characterizes the role of nuclear receptors NR4A1 and NR4A3 in drug C1 mediated apoptosis and has identified the functional relevance of the increase in the transcript...
- 168
- 384
- 0
Báo cáo khoa học: Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation potx
... expanded this strategy to gain general insights into the regulation of promoters of potential target genes of the Wnt pathway, which we identified by microarray screening Results Wnt target genes ... depend on the trigger type and on the level of interference with the Wnt pathway We conclude that the type of the trigger and the regulation level within the Wnt pathway decide about the gene ... FEBS S Ziegler et al Wnt target genes and the regulation of their promoters Table Number of transcription factor binding sites in promoters The promoters of the up-regulated genes were analysed...
- 16
- 300
- 0
Báo cáo y học: "Meta-analysis of primary target genes of peroxisome proliferator-activated receptors" pdf
... selected primary PPAR target genes In silico analysisfollowing page) In silico analysis of selected primary PPAR target genes Overview of the genomic organization of eight human PPAR target genes; ... SOM analysis of established primary PPAR target genes, clusters III and IV SOM analysis of established primary PPAR target genes, clusters III and IV The genes were sorted by SOM analysis with ... SOM analysis of established primary PPAR target genes, clusters I and II SOM analysis of established primary PPAR target genes, clusters I and II Overview of the genomic organization of 38 known...
- 29
- 529
- 0
Tài liệu Báo cáo khoa học: Implication of the glutamine synthetase ⁄glutamate synthase pathway in conditioning the amino acid metabolism in bundle sheath and mesophyll cells of maize leaves doc
... serine and glycine was reduced from 33% in the light to 25% in the dark (Fig 7A) Glutamine and asparagine were the major amino acids in the xylem sap in both the light (63% of the total amino acids) ... 3195 Amino acid metabolism and translocation M.-H Valadier et al Table Amino acid composition in leaves, and amino acid percentage ratio in the phloem exudates and leaves and xylem bleeding sap and ... molecular signalling in the expression of the genes and encoded enzymes involved in nitrate assimilation and amino acid synthesis [7] The stalk and leaves below and above the ear act as the source...
- 14
- 566
- 0
Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx
... of HO-1 induction by insulin through the PI3K ⁄ Akt cascade and the Nrf2 transcription factor in both transformed renal cells and primary mouse renal tubular epithelial cells Insulininduced HO-1 ... growth and differentiation On ligand binding, the insulin receptor tyrosine kinase initiates multiple signaling cascades, including activation of the phosphatidylinositol 3-kinase (PI3K) pathway and ... Insulin induces HO-1 A B C D 6 relative expression relative expression 4 0 Control 20 200 Control 2000 16 24 Insulin (h) Insulin (nM) E F Fig Insulin stimulates heme oxygenase-1 (HO-1) protein and...
- 12
- 377
- 0
Minimum Wages and Employment: A Case Study of the Fast-Food Industry in New Jersey and Pennsylvania pot
... - Page of - You have printed the following article: Minimum Wages and Employment: A Case Study of the Fast-Food Industry in New Jersey and Pennsylvania David Card; Alan B Krueger The American ... findings for the fast-food industry by comparing changes in teenage employment rates in New Jersey, Pennsylvania, and New York in the year following the increase in the minimum wage Again, these ... 38-54 Card, David and Krueger, Alan B "Minimum Wages and Employment: A Case Study of the Fast Food Industry in New Jersey and Pennsylvania. " National Bureau of Economic Research (Cambridge, MA) Working...
- 26
- 869
- 0
Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx
... Jolla, CA, USA) with pET2 8a( +)-wild-type Ec DosH as a template and using the following respective 5¢-sense primers: 5¢-gatga gtcgggagACCcagctggagaaaaaag-3¢, 5¢-gatgagtcgggagTTTcag ctggagaaaaaag-3¢, ... auto-oxidation [5], whereas Ala and Asn substitutions at Asp40, an amino-acid residue that interacts via two water molecules with the proximal ligand His77, markedly increased the rate of auto-oxidation ... kinetics of CO binding was not markedly in uenced by the mutation of Leu99 or Leu115 These findings are in contrast with the fact that mutations at the Met95 residue, the distal axial ligand in the...
- 14
- 390
- 0
Báo cáo khoa học: Transient increase of the labile iron pool in HepG2 cells by intravenous iron preparations Brigitte Sturm, Hans Goldenberg and Barbara Scheiber-Mojdehkar doc
... LIP The increase in ferritin by the iron preparations showed a pattern of behavior similar to the increase of the LIP The more iron appeared in the LIP the faster the synthesis of ferritin took ... parenteral iron preparations enter HepG2- cells, add iron to the labile iron pool and that the cells adapt their iron metabolism according to the size of incoming iron by highly increasing ferritin biosynthesis ... initiation of translation of ferritin by an increase in the labile iron pool (LIP) and the subsequent incorporation of labile iron into newly synthesized ferritin, followed by a decrease in the LIP...
- 8
- 501
- 0
Báo cáo hóa học: " A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: Potential impact on CTL epitopes" doc
... depending on their location, may impact on their binding inhibitors targeting these enzymes The viruses containing alterations may then be able to evade the inhibitory activities of the agents and are ... development of vaccines based on the auxiliary genes of HIV-1 Authors' contributions AS, VA, AK, AB, VS, RC and AC participated in the analysis of the predicted amino acid sequences of Vpr SM, DD and ... only one substitution This domain exhibits a total of 80 variant amino acids and 61 of them are of nonconservative in nature Several laboratories including ours have reported on the importance of...
- 17
- 434
- 0
Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
... analyzed whether treatment with the Akt-inhibitor ErPC3 would increase the short- time antineoplastic effects of ionizing radiation in the prostate cancer cell lines Combined treatment with ErPC3 and ... reduced the number of viable LNCaP, PC3 and DU145 cells as determined by the WST-1 test In PC3 and DU145 cells the antineoplastic effects of the combination treatment could mainly be attributed to the ... in the levels of Bcl-2 in both cell lines Moreover, ErPC3treatment decreased the levels of Mcl-1 in LNCaP cells Thus, in LNCaP cells the down-regulation of the two anti -apoptotic Bcl-2 proteins...
- 12
- 343
- 0
Báo cáo khoa học: "The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo" docx
... radiationinduced cell death by the alkylphospholipid perifosine in CWR22RV1 prostate cancer both in vitro and in vivo In vitro, perifosine reduced cell viability and clonogenic survival, and enhanced ... activity Eur J Cancer 1997, 33:442-446 doi:10.1186/1748-717X-6-39 Cite this article as: Gao et al.: The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo ... Perifosine enhances prostate cancer radiosensitivity in vivo A Control IR perifosine Combined Additive effect D B Control Perifosine 15 M Pefirosine 30 M Figure Perifosine increases prostate cancer...
- 8
- 306
- 0
Báo cáo y học: "Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues" doc
... fibroblasts The pro-inflammatory cytokines TNFα and IL1β further activated pFAK, pPyk2 and pSrc expression up to 120 The activation of the FAK- Src-paxillin-PLCγ pathway in RA ST lining and sublining ... together, our results demonstrate that FAK family kinases, including FAK and Pyk2, and their associated signaling intermediates, namely Src, paxillin and PLCγ are phosphorylated in RA ST lining and ... experiments Inflam, inflammatory score; Vasc, vascularity score; Lining, ST lining cell layer; Mac, subsynovial MΦs immunostaining in OA and ND STs The relative pattern of pFAK and pPyk2 expression...
- 10
- 393
- 0
Báo cáo y học: "Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis" pdf
... from synovia from OA and RA patients Discussion The novel finding of the present study is the identification of the key components of the cannabinoid receptor system in the knee synovia of patients ... levels of PEA were similar in the synovial fluid of OA and RA patients Thus, levels in the synovial fluid not simply reflect the level of synthesis/release and catabolism of endocannabinoids and ... summary, cannabinoid CB1 and CB2 receptor protein and RNA and the endocannabinoids AEA and 2-AG are present in the synovia of patients with end-stage OA and RA The presence of increased levels of...
- 14
- 500
- 0
Từ khóa: xenobiotic and other orphan nuclear receptors3 ced 4 ced 9 and egl 1 are conserved genes essential for programmed cell death in c elegansthe income distribution problem in latin america and the caribbeandual synthetic pathway in endothelial cells and interaction with et a and et b receptorsthe pyruvate dehydrogenase complex in cancer implications for the transformed state and cancerthe relationship between remedies in supervisory mechanisms and remedies available under generalobjectives after finishing the lesson students ss will be able to review and practice the main grammar learnt in unit 2 and prepare to do a forty five minute testresearch studies of qigong therapy for cancer for the past 20 years in china were reviewed from three different categories clinical study on human cancer patients in vitro study of cancer cells and in vivo study of cancer with qigong therapwhat is the evidence for pfmt either alone or in combination with adjunctive therapies when considering all treatment protocols for the treatment for sui in women immediately and up to 12 months after treatmentthe genome exposure defect in cancercustomizing the ribbon with xml in access databases and add ins2 the role of the extracellular matrix ecm in tooth morphogenesis and cytodifferentiationthe biology of cancer and its relationship to disparities in cancer occurrence and outcomescav 1 ko mice a new preclinical model to study the role of stromal cav 1 in cancer pathogenesis and progressionformulation process and storage conditions in the attainment enhancement and maintenance of the crispy crunchy character in wet dry and crusted food productsBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngThơ nôm tứ tuyệt trào phúng hồ xuân hươngTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ