Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 1

... silk fibroin fiber scaffolds containing bone morphogenetic protein (BMP-2) and/ or nanoparticles of hydroxyapatite (nHAp) using electrospinning, and showed its ability in inducing in vitro bone formation ... the applications of electrospinning and supercritical CO2 foaming techniques With the aid of physical and chemical modifications on mechanical properties and surface charge, the applications of ... developed in this thesis may be of Chapter 18 importance in combining tissue engineering and drug delivery nicely, with potential in clinical applications 1. 3 Drug delivery dosage forms In addition...

Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 2

... 1660-1680 Turn 26 2 38±18 30 2 29±1 26 2 1681-16 92 β- Antiparallel 26 ±3 24 ±4 25 2 24±1 26 2 α-helix percentage is the most important criterion in judging the denaturation of protein In Figure 3.9, ... conformations BMP -2 from from from F1 components native F2 F3 F4 (cm-1) 1647-1660 α-Helix 12 1 9 2 11 2 11 2 12 1 1615-1636 β- sheet 26 ±4 19±7 24 ±6 26 2 25 2 1637-1646 random 10±1 10±3 10±1 10 2 11±1 1660-1680 ... 3.4 .2 In vitro release results The shape of the release curve (Figure 3.6) obtained from this experiment is consistent with the in vitro release profiles of many studies of bone engineering (Jansen...

Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 3

... 4 .3 Comparison of performance scores for all samples at specific intervals* Control F1 F2 F3 F4 Week 0.00 0.00 0 .33 0.67 1 .33 Week 1.67 2.00 1.00 2.00 2.00 Week 2.67 3. 33 2.67 3. 33 3 .33 Week 3. 67 ... with increasing HAp content From 408ppm in scaffold F1, the DCM content dropped to 34 035 0ppm in scaffolds F2 and F4, and dropped even further to almost 33 2ppm in scaffold F3 The hydrophilicity of ... applied at 1 :30 0 dilution for 60 at 37 ºC Peroxidase activity was detected by 0.4 mg/L of 3, 3 -diaminobenzidine in phosphate buffer at a pH of 7 .3, in the presence of 0.12 percent of H2O2 Then...

Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 4

... DNA release from different scaffolds in PBS at 37 ºC Irrespective of the release modes, the release rate of plasmid DNA increases with increasing loading of HAp nanoparticles, but the whole release ... their release properties and morphology We further explored the in vitro study of plasmid DNA by investigating the effects of HAp content and the different methods of DNA loading on the physical and ... remaining 15-20% of DNA could be released within the following 4- 5 days This time scale of release is comparable to other dosage forms, like nanoparticles and microparticles On the other hand,...

Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 5

... three kinds of scaffolds was well maintained, which helped improve the formation of new bone and the healing of segmental defects in vivo Groups A, B and C released DNA or DNA nanoparticles in different ... solution (0.02% in mM sodium acetate buffer, pH 5. 0) and DNA solution of 100µg/mL in 5- 50 mM of sodium sulfate solution were preheated to 50 -55 °C separately An equal volume of both solutions ... healing is observed for samples A1, B1, B3, and C1 Furthermore, this also confirms that during the progress of bone healing, tissue reabsorbing/remodeling, and the in growth of blood vessel are interactively...

Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 6

... fabricated by the combination of spray drying and supercritical CO2 foaming techniques and the effects of chitosan incorporation on the following factors was investigated: in vitro release of DNA, cell ... cases of scaffolds F1 and F2 To evaluate the effects of the fabrication process (including spray drying, supercritical CO2 foaming, and handling of samples) on the molecular integrity of plasmid ... maintained after going through the processes of spray drying, supercritical CO2 foaming and post-processing conditions (handling of scaffold, incubations, and lyophilization) As shown in Figure 7.7b,...

Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 7

... promising results in controlled release of DNA, but the release rate of DNA and subsequent expression of target protein is too low, especially in the initial stage (Figures 7. 5a and 7. 7b) Therefore, ... by a period of slow release profile Compared with the release profile of F0, the release profiles of F1 and F2 are relatively linear and sustainable The constant rate of the in vitro release processes ... an initial and significant release of DNA is demanded in order to optimize this kind of devices Lysine, an α-amino acid of chemical formula HO2CCH(NH2)(CH2)4NH2, pKa 10.54 and hydrophobility of...

Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 8

... potential applications of electrospinning and supercritical CO2 foaming techniques in the fabrication of three dimensional scaffolds for controlled release and bone regeneration These two techniques ... sustained release of DNA, possibly due to a balance of electrostatic interaction and hydrophilic interaction between DNA and the surface of Lysine pepetide modified foams The sustained release of ... results indicate that the bioactivity of BMP-2 plasmid released from all the three kinds of scaffolds was well maintained, which helped improve the formation of new bone and the healing of segmental...

extraction of liquid crystals from flat panel display devices using both liquid and supercritical carbon dioxide

... Demonstration of the disassembly of a defunct LCD Carbon dioxide extraction was carried out using a Thar Technologies SFE-500F-2-FMC System and liquid withdrawal carbon dioxide (99.9 %) The extraction ... for extraction of liquid crystals from defunct display devices with high efficiency MATERIALS AND METHODS A LCD (Figure 2A) device may be disassembled by removal of screws securing the back panel ... potential recovery of tonnes of liquid crystals with a market value of between 27 and 187 million dollars dependent on liquid crystal quality; 900 kg of indium and 8,000 tonnes of optical quality...

Optimization of microwave, ultra sonic and supercritical carbon dioxide assisted extraction techniques for curcumin from curcuma longa

... ) % extraction of curcumin using acetone Fig Curcumin extraction by supercritical CO2 ( ) % Extraction of curcumin from curcuma powder using supercritical CO2 3.3 Ultra- sonic assisted extraction ... extraction (UAE) 3.4 Supercritical carbon dioxide extraction (SC CO2 E) 3.3.1 Effect of ultra- sonic irradiation Fig shows the effect of ultra- sonic irradiation on curcumin extraction from C longa rhizome ... rhizomes ( ) % Extraction of curcumin using ethanol from ethanol soaked curcuma powder, ( ) % extraction of curcumin using ethanol from water soaked curcuma powder and ( ) % extraction of curcumin...

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identification, design and synthesis of oxygenated hydrocarbon-based carbon dioxide-soluble polymers for chemical and petroleum engineering applications

... ABSTRACT IDENTIFICATION, DESIGN AND SYNTHESIS OF OXYGENATED HYDROCARBON-BASED CO2-SOLUBLE POLYMERS FOR CHEMICAL AND PETROLEUM ENGINEERING APPLICATIONS Lei Hong, Ph.D University of Pittsburgh, 2006 ... defended on March 29, 2006 and approved by Dr Eric J Beckman, Professor, Chemical and Petroleum Engineering Department Dr J Karl Johnson, Professor, Chemical and Petroleum Engineering Department ... Professor, Department of Chemistry Dissertation Director: Dr Robert M Enick, Chairman and Professor, Chemical and Petroleum Engineering Department ii Copyright © by Lei Hong 2006 iii ABSTRACT IDENTIFICATION,...

Thermodynamics of cholesterol compounds in supercritical carbon dioxide experimental and modeling studies

... THERMODYNAMICS OF CHOLESTEROL COMPOUNDS IN SUPERCRITICAL CARBON DIOXIDE: EXPERIMENTAL AND MODELING STUDIES HUANG ZHEN (M ENG., TIANJIN UNIVERISTY) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR ... Largescale supercritical CO2 extraction has been in commercial operation since the late 1970s for decaffeination of coffee and tea, refining of cooking oils, recovering of flavors and pungencies ... butyrate and benzoate in supercritical CO2 Experimentally determined solubility isotherms in pure supercritical carbon dioxide were obtained over a range of operating conditions from 90 to 270 bar and...

Báo cáo lâm nghiệp: "Soil carbon dioxide eﬄux in pure and mixed stands of oak and beech" potx

... Three sampling areas were located in each of the quasi -pure stands dominated either by oak or beech and four were located in a mixture of both species The ne roots of the forest oor and of the Ah ... the mixed and oak stands which showed similar annual FFRs (Tab V) FFR accounted respectively for 28, 30 and 46% of TSR in the oak, mixed and beech stands The annual heterotrophic respiration of ... root abundance in the three stands Leaf litterfall was similar in the oak, mixed and beech stands (P = 0.4900, Tab II) In contrast, the forest oor mass increased in the order: oak < mixture ...

Báo cáo khoa học: " The effects of ectomycorrhizal status on carbon dioxide assimilation capacity, water-use efficiency and response to transplanting in seedlings of Pseudotsuga menziesii (Mirb) Franco" docx

... demand function (D) which defines the mesophyll photosynthetic capacity and, ii), the photosynthetic CO supply function (Su) defining the diffusional limitation to CO as2 similation For determining ... strain used as mycobiont and ii), that there may be a discrepancy between effects of mycorrhizae on stem elongation on the one hand and on diameter and weight growth on the other Tyminska et al (1986) ... in order to buffer the Pi in the cytoplasm and ii), that an overall minimum cytoplasmic Pi concentration of between 5-10 mmol· is required to sus-1 l tain optimal rates of photosynthesis in the...

extraction of essential oil from lemongrass using supercritical carbon dioxide

... Properties of Lemongrass Oil 32 Table 5: Physicochemical Properties of main components of essential oil 34 Table 6: Investigation of SC CO2 extraction of essential oil from lemongrass ... result of Lemongrass essential oil from steam distillation, stem 106 Figure 38: GC result of Lemongrass essential oil from steam distillation, leaf 106 Figure 39: GC results of essential oil from ... results of essential oil from Lemongrass, Leaves (RSM) 169 Appendix I: Analyses results of essential oil from Lemongrass, stems (RSM) 174 x Appendix J: Effects of extraction conditions on extraction...

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