Mitochondrial integrity and antioxidative enzyme efficiency in fischer rats effects of ageing and epigallocatechin 3 gallate intervention 6
Mitochondrial integrity and antioxidative enzyme efficiency in fischer rats effects of ageing and epigallocatechin 3 gallate intervention 4
... also examined the changes of gene expressions of CAT, SOD1, SOD2 and GPx in both young (PDL20 -30 ) and old (PDL >45 ) HDF after 24 hours of treatment with EGCG, since these enzymes are mostly influenced ... expressions both in the young and the old HDF In the young HDF, the gene expressions of CAT, SOD1, SOD2 and GPx increased in response to 25 μM 87 EGCG by 94. 1, 61.9, 44 .6 and 139 .2 % respectively ... that in the untreated group, the gene expressions of CAT, SOD2 and GPx in the young HDF were much higher than that in the old HDF After 24 hours of incubation with EGCG, all the enzymes increased...
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Mitochondrial integrity and antioxidative enzyme efficiency in fischer rats effects of ageing and epigallocatechin 3 gallate intervention 1 2
... listed in Table S cerevisiae C elegans D melanogaster M musculus lag1 daf -2 sod1 prop -1 lac1 age -1/ daf- 23 cat1 p66shc ras2 akt -1/ akt -2 ras1 phb1 daf -16 daf -18 phb2 daf - 12 mth cdc7 ctl -1 mclk1 bud1 ... significant 3. 2 Part two: Effects of epigallocatechin- 3- gallate on mitochondrial integrity and antioxidative enzyme activity in aging process of human fibroblast 3. 2 .1 Cell culture and EGCG preparation ... disorders 42 2 .2 .1 Study of mitochondrial integrity and antioxidant defense system efficiency in the young and old Fischer 34 4 rats Firstly, in order to understand mitochondrial malfunction in aging,...
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Mitochondrial integrity and antioxidative enzyme efficiency in fischer rats effects of ageing and epigallocatechin 3 gallate intervention 1 3
... cellular aging studies [16 0, 16 1] The LC50 value of EGCG and its anti- and pro-oxidant effects are examined initially Then in the short term study, HDF is exposed to H2O2 induced oxidative stress and ... 6.25, 12 .5, 25, 50 and 10 0 μM were added into the MEM For the first 30 min, 10 0 μM of EGCG cleared about 32 % free radicals of DPPH but its radical scavenging activity declined over time On day 3, ... below μM in response to lower concentrations of EGCG (Figure 16 C) 83 Figure 16 Anti- and pro-oxidant effects of EGCG in MEM in the presence and absence of HDF (A) Various concentrations of EGCG...
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Mitochondrial integrity and antioxidative enzyme efficiency in fischer rats effects of ageing and epigallocatechin 3 gallate intervention 1
... 61 3. 3 .10 Antioxidative enzyme activities .62 3. 3 .11 Antioxidative enzyme gene expressions 62 3. 3 .12 Microarray and data analysis 63 3 .3. 13 Statistics 64 Main results ... activity in Fischer 34 4 rats; Mechanisms of Ageing and Development, 12 8 (3) :286-92 II Meng Q, Velalar CN and Ruan R, (2008); Effects of epigallocatechin- 3- gallate on mitochondrial integrity and antioxidative ... peroxidation ………………………………….… 12 1 .3. 3.2 Change of protein structure ……………………… …… 13 1 .3. 3 .3 DNA damage ……………………………………….…… 13 1 .3. 4 Other functions of ROS ………………………………………… 15 1 .3. 5 Antioxidant defense...
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Mitochondrial integrity and antioxidative enzyme efficiency in fischer rats effects of ageing and epigallocatechin 3 gallate intervention 5
... process of HDF reaching the end point, samples were collected, and intracellular ROS accumulation, mitochondrial integrity, antioxidative enzyme activities and gene expressions were examined and ... Effects of EGCG in long term treatment In the long term treatment, the middle-aged HDF (PDL 35) was continuously cultured in MEM with 12 .5 μM of EGCG until they reach replicative senescence In ... long term incubation of middle-aged HDF with 12 .5 μM of EGCG significantly (P...
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Mitochondrial integrity and antioxidative enzyme efficiency in fischer rats effects of ageing and epigallocatechin 3 gallate intervention 6
... ILMN _6 63 7 5a ILMN_55276e ILMN_5 432 7e ILMN _61 732 e ILMN _65 726e ILMN_49450a ILMN_52 1 36 e ILMN_57 63 0 a ILMN _6 539 0c ILMN_ 537 85e ILMN _64 064 e ILMN_5 268 6c ILMN _6 737 3c ILMN_58243e ILMN _6 63 8 2e ILMN_51 069 e ILMN_59474e ... 2.007 1. 962 1.9 46 1.944 1.9 16 1. 864 1.815 1.784 1 .69 8 1 .68 9 1 .67 5 1 .66 6 1 .66 2 1 .64 5 1. 63 7 1. 63 0 1.577 1. 567 1.558 1.554 1.540 1.520 CR 1.008 -1 .38 5 2. 967 1.874 -1.259 -1.1 13 -1.115 4 .60 1 3. 869 -2.888 ... dose and high dose EGCG interventions* 117 Gene Access No ILMN_55995e ILMN_48157e ILMN _69 716a ILMN_5 835 2a ILMN _68 954e ILMN_50589e ILMN _66 976e ILMN_ 535 36c ILMN _6 538 2a ILMN_58547c ILMN _6 63 7 5a ILMN_55276e...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 3) docx
... cerebellum of a nitrazepam user at autopsy, and measured nitrazepam and 7-aminonitrazepam both immediately and 10 days (at 4° C) after autopsy as shown in > Table 3.1 Postmortem redistribution of drugs ... in an autopsy case of a digoxin-user Jones and Pounder [25] reported analytical results of imipramine and its metabolite desipramine in blood and various organs of a victim, who had died by ingesting ... using rats, that the concentrations of amitriptyline and its metabolite nortriptyline in blood of the heart increased within h after death, and those in blood of the inferior vena cava increased...
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Aesthetic issues in spatial composition: effects of position and direction on framing single objects pot
... functions for right-facing and left-facing instructional conditions The results of a two-way analysis of variance on the positions of the centers of the objects indicate a main effect of facing direction ... pleasing if the subject were positioned decidedly off center and facing out of the frame, violating these conventions to convey feelings of isolation, loneliness, and/ or longing Although such considerations ... matter and what effects they have The present article reports an initial scientific exploration into two fundamental aspects of spatial composition: the position and facing direction of a single...
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![Báo cáo khoa học: Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes Effects of charge and nonbilayer phase propensity of the membrane pot](https://media.store123doc.com/images/document/14/rc/ld/small_ldo1394248806.jpg)
Báo cáo khoa học: Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes Effects of charge and nonbilayer phase propensity of the membrane pot
... reaction of 7,8-diols and the enhanced nonbilayer phase propensity in membranes containing PtdEtn Effect of lipids on the stereoselectivity of epoxidation The stereoselectivity of the epoxidation ... redistribution of the substrate between the aqueous and the membrane phase and is brought about by a change in the nonbilayer phase propensity of the membrane In accordance with this hypothesis, it ... demonstrated by the ratio of the formation rates of the two diol-epoxides, DE2 and DE1 These differ only in the conformation of the 9,10-epoxy-group, anti in DE2 and syn in DE1 The respective data in Fig...
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Báo cáo toán học: " Overview of principles and implementations to deal with spatial issues in monitoring environmental effects of genetically modified organisms" pot
... Overview of principles and implementations to deal with spatial issues in monitoring environmental effects of genetically modified organisms Winfried Schröder†1 and Gunther Schmidt*†1 Chair of ... complete monitoring schemes covering approximately 4,000 species and 145 different habitat types and addresses of 239 monitoring coordinators and institutions Furthermore, the database contains information ... needed for monitoring and modelling dispersal and persistence of GMP as well as planning GMP EM with respect to coexistence issues in agricultural landscapes The data described in the following have...
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báo cáo hóa học:" Overview of principles and implementations to deal with spatial issues in monitoring environmental effects of genetically modified organisms" pot
... Overview of principles and implementations to deal with spatial issues in monitoring environmental effects of genetically modified organisms Winfried Schröder†1 and Gunther Schmidt*†1 Chair of ... complete monitoring schemes covering approximately 4,000 species and 145 different habitat types and addresses of 239 monitoring coordinators and institutions Furthermore, the database contains information ... needed for monitoring and modelling dispersal and persistence of GMP as well as planning GMP EM with respect to coexistence issues in agricultural landscapes The data described in the following have...
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Báo cáo y học: "Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis" docx
... pathologically crucial in the early effector phase in arthritis Role of various inflammatory cytokines in GPI -induced arthritis To determine the effects of inflammatory cytokines during the effector phase ... that these cytokines could play a crucial role in the induction of arthritis in GPI -induced mice Anti-cytokine mAbs and co-stimulator blockade inhibit in vitro cytokine production To delineate the ... (c) cytotoxic T-lymphocyte antigen immunoglobulin (CTLA-4Ig; on days and 12); (d) CTLA-4Ig (on days 12 and 16); and (e) or anti-IL-6 mAb just after the onset of arthritis (on day 8, on days and...
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Báo cáo y học: "Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocyte" ppsx
... modulation of the activation and DNA binding activity of NF-κB Inhibition of IKKβ kinase activity by EGCG The effect of EGCG on the phosphorylating activity of IKKβ kinase was determined using an ... Hasnain A, Lalonde M, Goldberg VM, Haqqi TM: Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1β-induced activity and expression of cyclooxygenase2 and nitric oxide synthase-2 in human ... regulator of inflammatory cytokine gene expression and plays a crucial role in immune and inflammatory response After the ubiquitination and phosphorylation of IκBα, the inhibitor is degraded and the...
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Báo cáo y học: "Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise" pdf
... Haqqi TM: Green tea polyphenol epigallocatechin- 3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes J Pharmacol ... c-Jun-N-terminal kinase induced by IL-1β [17] This resulted in the reduced accumulation of phosphorylated c-Jun and activation protein-1 DNA binding activity, and of activation protein-1-mediated in ammatory ... mimicked by Akt and NF-κB inhibitors Interestingly, Mcl-1 degradation by EGCG sensitized RA synovial fibroblasts to TNFαinduced cleavage of poly ADP-ribose polymerase protein and apoptosis Our finding...
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Báo cáo y học: "In vitro and in vivo antitumor effects of acetylshikonin isolated from Arnebia euchroma (Royle) Johnst (Ruanzicao) cell suspension cultures" pps
... effects of acetylshikonin on the growth of tumor Inhibitory 3) Inhibitory effects of acetylshikonin on the growth of tumor cells (n = 3) Inhibitory rate on LLC Cyclophosphamide and acetylshikonin ... Figure determined by cell acetylshikonin on (n growth of A549 Inhibitory effects ofgrowth curve assaythe = 3) Inhibitory effects of acetylshikonin on the growth of A549 determined by cell growth ... acetylshikonin and isobutyrylshikonin, have been isolated from the culture vegetal cell suspension This study aims to evaluate the in vivo and in vitro antitumor effects of acetylshikonin extracted from...
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