Insights into the mechanism of safingol and its potential to synergize with anti cancer drugs

Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx

... considers the 4541 Interaction of arginase II with substrate and manganese ions ´ V Lopez et al Table Kinetic properties of the arginase activities of wild-type and mutant variants of human arginase II ... activity of the Asn14 9Asp variant, it is clear that the interactions of arginase II with l-arginine and agmatine are greatly altered by replacement of this residue with aspartate To the best of our ... mutations on the affinity of metal binding to arginase II To further examine the effects of the His120fiAsn and His145fiAsn mutations on the interaction of the enzyme with manganese ions, maximally...

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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx

... indicate that the heme attachment itself is not catalyzed enzymatically CONCLUSIONS AND PERSPECTIVE Highly homologous monoheme Class I cytochromes c are available from a wide range of bacteria, from ... established, and are applicable to the elucidation of the dynamic features of cytochromes c It is of interest to characterize cytochrome c with respect to protein maturation, folding, stability, ... coli ccm (cytochrome c maturation) deletion strain substantially expresses Hydrogenobacter thermophilus cytochrome c5 52 in the cytoplasm: availability of haem influences cytochrome c5 52 maturation...

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Báo cáo khoa học: Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP ppt

... gels of purified recombinant SR (left) and the PDZ6 domain of GRIP (middle) The circular dichroism spectrum of purified PDZ6 domain of GRIP is shown in the right panel (C) D -Serine synthesis by recombinant ... Characterization of SR activation by the PDZ4-PDZ5-PDZ6GAP2-PDZ7-end module of GRIP D -Serine synthesis by recombinant SR in the presence of increasing molar ratios of (A) the recombinant PDZ6 domain or ... reaction but not the oligomeric state of the enzyme (A) Michaelis–Menten representation and Lineweaver–Burk plot of the activation of brain SR by ATP Assays were performed in the presence of mM Ca2+...

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Báo cáo khoa học: Insights into the design of a hybrid system between Anabaena ferredoxin-NADP+ reductase and bovine adrenodoxin pot

... generated an artificial but functional ET chain composed of Anabaena FNR, bovine Adx and bovine CYP1 1A1 The time course of the reaction followed at 450 nm fit to a mono-exponential process with a ... Kinetic parameters for the anaerobic reaction between FNRrd and Adxox Data calculated from steady-state spectra recorded in Fig 2A at 414 nm Adx concentration dependence of (A) kobs1, kobs2 and V0 ... mixed in the cell measuring compartment and lM CYP1 1A1 was placed in the second compartment After the samples were made anaerobic, an excess of NADPH was added to the FNR/Adx mixture to allow Adx...

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Báo cáo y học: "omparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi" pps

... Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi Genome Biology 2011 12:R7 Submit your next manuscript to BioMed Central and take full advantage of: ... investigate the fundamental biology and pathogenicity of dermatophytes [8] Despite the above mentioned phenotypic differences, A benhamiae and T verrucosum are phylogenetically very closely related, and ... for glycolysis, tricarboxylic acid cycle, glyoxylate cycle, pentose phosphate shunt, and synthesis of all 20 standard amino acids and the five nucleic acid bases Moreover, dermatophytes appear...

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Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data" potx

... targeted by miRNA (y- axis) as the percentage of disorder increases in the proteome The datasets for the transcripts encoding the disordered proteins (burgundy) and ordered proteins (mauve) and the proteome ... highly disordered proteins with the highly ordered proteins, an increase of 23.5% is observed instead of 42.5%, and comparing the disordered proteins with the ordered proteins, an increase of 4.4% ... produced in the cell is affected by the expression level of its mRNA transcript The levels of gene expression are controlled in the cell in a number of different ways - for example, by varying the...

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An investigation into the reality of teaching and learning speaking skills to the 2nd year non-major english students at pre-intermediate level of proficiency at hanoi university of industry

... GRADUATE STUDIES CANDIDATE’S STATEMENT I certify that the minor thesis entitled: An investigation into the Reality of Teaching and Learning Speaking Skills to the 2nd year non-major English students ... VIETNAM NATIONAL UNIVERSITY HANOI COLLEGE OF FOREIGN LANGUAGE POST GRADUATE STUDIES -***** - HOÀNG BÍCH THỦY AN INVESTIGATION INTO THE REALITY OF TEACHING AND LEARNING SPEAKING SKILLS TO THE 2ND YEAR ... teaching and learning Speaking to the 2nd year non-major English students at Pre-Intermediate level of Proficiency at your University? A Difficult and boring C Interesting and stimulating B Difficult...

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