Studies on structures, dynamics and interactions with small molecules of CNS regeneration inhibitory components associated with nogo a and epha4

... study structures, dynamics and protein-protein interactions, as well as protein -small molecule interactions for two CNS regeneration inhibitors: Nogo- A and EphA4 receptor Intracellular Nogo- A protein ... solution structure of EphA4 LBD 132 3.5.5 Comparison of NMR solution structure and crystal structure 137 3.6.6 Dynamics study of free EphA4 and analysis of relaxation data 139 3.7.7 Modelfree analysis ... ligand binding domain with compound 1and compound Figure 3.25 Characterization of the interactions with two small molecule antagonists Figure 3.26 Models of EphA4 (chainA) in complex with small...

Báo cáo khoa học: Surface-enhanced vibrational spectroscopy for probing transient interactions of proteins with biomimetic interfaces: electric field effects on structure, dynamics and function of cytochromec doc

... techniques, as the frequencies and band intensities of vibrational transitions represent a unique fingerprint of the specific conformation of a molecule SERR and SEIRA spectroscopy of cytochrome c [10] Both ... excitation of surface plasmons of Au is restricted to the region above 550 nm [10] This limitation has severe consequences for SERR spectroscopy: since the electronic transitions of most of the ... bands allow monitoring equilibria and dynamics of the spin, coordination and ligation configuration of cytochrome c [10,27] Third, when excitation lines close to the weak Q-transition of the haem...

Báo cáo khoa học: "Comparative studies on the pathogenicity and tissue distribution of three virulence variants of classical swine fever virus, two field isolates and one vaccine strain, with special regard to immunohistochemical investigations" ppt

... in the cytoplasm of the epithelial (Figure 8), mononuclear and reticular cells When using the probe on the sections of the uninfected animals or the BHV-5 specific probe on the sections of the ... species The observations are useful for the early diagnosis of classical swine fever, with special regard to the detection and identification of the very mild or inapparent clinical manifestations The ... pathology and to compare the applicability of virus detection methods These observations will contribute to a better understanding of the viral pathogenesis and to the introduction of more effective...

Studies on the morphology and melocular characteristics of small intestinal trematodes in human in some provinces and effective treatment in community (2010 2013)

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STUDIES ON CATTLE MILK AND MEAT PRODUCTION IN FOGERA WOREDA: PRODUCTION SYSTEMS, CONSTRAINTS AND OPPORTUNITIES FOR DEVELOPMENT doc

... declined due to production constraints such as lack of production inputs and lack of information on dairy and beef production and marketing and also the dairy and beef market are localized Therefore, ... the production constraints of milk and meat of the woreda and to indicate the interventions for the indicated production constraints LITERATURE REVIEW 2.1 Origin and Current Classification of ... STUDIES ON CATTLE MILK AND MEAT PRODUCTION IN FOGERA WOREDA: PRODUCTION SYSTEMS, CONSTRAINTS AND OPPORTUNITIES FOR DEVELOPMENT BELETE ANTENEH TARIKU A THESIS...

Studies on Business Administration and Management and ethical and social values docx

... Studies on Business Administration and Management and the ethical and social values Keywords: Values, higher education, research JEL codes: A13, A23 Abstract: ... physical values, intellectual values, affective values, moral values, social values, ecological values, etc Different studies on value classification have been done, one that is worth mentioning ... year State Private Mean Standard deviation Mean Standard deviation Mean Standard deviation Mean Standard deviation Mean Standard deviation Mean Standard deviation Responsibility 4.3 0.79 4.6 0.56...

Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx

... The chaotrope-induced unfolding was almost fully reversible in both forms of the protein Removal of the perturbation makes the protein regain its native form The unfolding reactions of both forms ... as the major and the minor forms of the holoACP structure, on the basis of their percentage contributions (65% and 35%, respectively) to the overall structure of the protein The structures of the ... better stability than the other form (Fig 4C) The DG of stability is on an average 20% greater in the case of the holoprotein as compared to the apoprotein Similarly, the Cm of the holo form always...

STUDIES ON THE ECOLOGY AND CONSERVATION OF BUTTERFLIES IN EUROPE: Vol. 1: General Concepts and Case Studies pptx

... Studies on the Ecology and Conservation of Butterflies in Europe STUDIES ON THE ECOLOGY AND CONSERVATION OF BUTTERFLIES IN EUROPE Vol 1: General Concepts and Case Studies Edited ... Nowicki, Studies on the Ecology and Conservation of in Europe Sofia – Moscow Vol 1: General Concepts and Case Studies, p 38 Altitudinal life-history variation and temperature adaptations in copper butterflies ... Proceedings The first volume General Concepts and Case Studies encompasses the Ecology of Butterflies (3 sections) and the Conservation of Butterflies and Global Change” (two sections), while the...

Báo cáo Y học: Structural studies on the core and the O-polysaccharide repeating unit of Pseudomonas aeruginosa immunotype 1 lipopolysaccharide pot

... In immunotype 1, the outer core has at least one O-acetylation site and the O-acetyl group is present in the core of a minority of the LPS molecules The position of the O-acetyl groups in the core ... all of the data together, the structures of the core and core with one O-polysaccharide repeating unit in the LPS of P aeruginosa immunotype were established (Fig 7) DISCUSSION Previously, the ... remainder by ESI MS and NMR spectroscopy enabled determination of not only the biological repeating unit but also of the mode and the site of the linkage between the O-polysaccharide and the core It...

incomplete contracts and corporate governance theory and evidence---case studies on chinese banking and u.s. franchising

... Branding-inherent Demand SAR: Spatial Autoregressive SMA: Spatial Moving Average Bond: Bond’s Franchise Guide Incomplete Contracts and Corporate Governance: Theory and Evidence Case Studies on ... of incomplete contracts has not been agreed upon yet One popular view is that incomplete contract theorists restrict the class of contracts they consider to an ad hoc subset of complete contracts ... of complete contracts which is closely related to the theory of implementation or mechanism design, the incomplete contracts approach pioneered by Grossman and Hart (1986) and Hart and Moore (1990)...

Numerical studies on collective motion and polymer statistics

... biology, namely the collective motion and polymer statistics The first part of the thesis focuses on collective motion Collective motion, or flocking behaviour studies the common coordinated behaviour ... NUMERICAL STUDIES ON COLLECTIVE MOTION AND POLYMER STATISTICS WANG NAN (B.Sc.(Hons), National University of Singapore) A THESIS SUBMITTED FOR ... distrubution at hand, we can get the force extension relationship and free energies of the chains with different conformations vi List of Figures 1.1 A gallery of images related to collective motion...

Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation body

... relation to learning and memory formation requirements Furthermore, the molecular mechanisms underlying the MFs redistribution during learning and memory formation are still under investigation ... hilus and CA3 area, comprise the second synapse of the hippocampal circuit In this trisynaptic model of the hippocampus, based on the observations of the MFs presynapses and their locations, the ... for the investigations on the learning- dependent morphological malleability, as well as the relations of synaptic plasticity with long-lasting memory The correlations between the basal size of the...

Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation

... 5.2.3.1 Fear conditioning training 115 5.2.3.2 Short-term contextual memory and cued memory test 115 5.2.3.3 Retention and extinction of long-term contextual memory and cued memory ... which have been done in this thesis to investigate the underlying mechanisms of learning process and long-term memory formation In part I, two projects have been focused on the hippocampal mossy ... and x long-term memory procedures Investigations on the learning- induced presynaptic plasticity might shed lights on the complicated mechanisms underlying the hippocampalrecruited long-term memory...

Biophysical studies on DNA micromechanics and bacterial nucleoid organization

... 3.3.6 B -DNA, S -DNA and ssDNA fractions under 82 pN in different salt concentration ranging from 0.5 to 100 mM NaCl at 23 ˚C 79 Figure 3.3.7 Transition between S -DNA and two parallel ssDNA under ... 4.3.14 DNase I digestion assays of DNA accessibility restriction by rigid Lsr2 -DNA complex formed on extended DNA 115 Figure 4.3.15 Multiplex single -DNA DNase I digestion assays of rigid Lsr 2DNA ... Lsr2 -DNA nucleoprotein complex formation on 19,327 bp GCrich DNA (GC = 57 %) and 15,003 bp AT-rich DNA (AT = 54 %) 120 xii LIST OF ABBREVIATIONS DNA = deoxyribonucleic acid dsDNA = double-stranded...

Studies on metal oxides and cobalt nitride as prospective anodes for lithium ion batteries

... presents studies on mixed metal oxides and cobalt nitride as prospective anode materials for LIBs based on the Li- recyclability by electrochemical processes such as ‘conversion’ reaction involving ... VI.4.Conclusions 251 References 253 Conclusions and Suggestions for Future Work 256 x Summary Lithium ion batteries (LIBs) are the promising dc- energy source for portable electronic devices such as ... nano-size metals or formation/ decomposition of Limetal alloy Chapter I describes the LIBs, principle of operation, development of LIBs, applications, world market and need for R&D and selection criterion...

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