The application of pharmacoinformatics in enhancing pharmaceutical care of patients with cancer

Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"

... of patients with bipolar disorder were obese Pharmacotherapy and affective episodes both influence appetite and physical activity, thereby increasing the risk for obesity Obesity in bipolar patients ... metabolite syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within ... of general medical conditions may be delayed As the physician with the most (and often the only) contact with these patients, psychiatrists need to be vigilant in detecting early signs and symptoms...

Báo cáo y học: "A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting" pptx

... this article as: Hsieh et al.: A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric ... 5-hydroxytryptamine (5-HT) 2A antagonist activity [6] and 5-HT 1A partial agonist activity [7,8] In addition, aripiprazole has minimal affinity for a2 adrenergic receptors, H1 histamine receptors ... setting and to evaluate the effectiveness of aripiprazole in a Taiwanese patient population Findings reported here demonstrate the broad effectiveness of aripiprazole in Taiwanese patients with schizophrenia...

Báo cáo y học: "Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis" potx

... reported the first systematic histological study of zygapophyseal joints in patients with AS [10] In the present study, we first examined whether inflammation in the spine of patients with AS, ... and microscopic assessment of zygapophyseal joints (a) Macroscopic picture of a zygapophyseal joint from a patient with ankylosing joints spondylitis (AS) (b) Hematoxylin and eosin staining of ... correlation of histopathological analysis of the spine and inflammation as visualized by MRI has also not previously been done In the sacroiliac joints of patients with AS, a correlation of MRI findings...

Báo cáo y học: "Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years" ppt

... Evaluation of Recombinant Infliximab Therapy Study Group: Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis Arthritis Rheum 20 08, 58:3063-3070 ... Selection of a method for scoring radiographs for ankylosing spondylitis clinical trials, by the Assessment in Ankylosing Spondylitis Working Group and OMERACT J Rheumatol 20 05, 32: 2048 -20 49 Heijde D ... Arthritis Rheum 20 06, 54 :21 36 -21 46 Maksymowych WP, Rahman P, Keystone E, Wong R, Inman R, for the M03-606 Study Group: Efficacy of adalimumab in active ankylosing spondylitis (AS)-Results of the Canadian...

báo cáo khoa học: " Connectedness of healthcare professionals involved in the treatment of patients with Parkinson’s disease: a social networks study" pot

... connected within their geographical area than in the total network Measures related to individual networks of the health professionals showed a large variation The number of patients treated per professional ... consensus among the clinical authors of this paper We hypothesized that health professionals treating many Parkinson patients and health professionals in specialized hospital settings would have higher ... analysis Data analysis Data were entered into a squared data-matrix with the health professionals in the rows and columns and values in the cells to indicate presence or absence of a connection (values...

Báo cáo y học: "Improvement in symptoms and signs in the forefoot of patients with rheumatoid arthritis treated with anti-TNF therapy" ppsx

... effects of antiTNF therapy in RA patients with specific focus on the forefoot using the hypothesis that forefoot symptoms, like those of hand joint symptoms, would improve with this intervention ... beneficial in monitoring the progression of active inflammation in rheumatoid arthritis [13] and in the monitoring of biologic therapy [14-16] The aim of this study was to evaluate by means of US, the ... article as: Bowen et al., Improvement in symptoms and signs in the forefoot of patients with rheumatoid arthritis treated with anti-TNF therapy Journal of Foot and Ankle Research 2010, 3:10 ...

Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf

... shown) The inhibition of BLyS, APRIL, and the heterotrimers by atacicept is consistent with the observed effects of atacicept and/ or murine TACI-Ig in preclinical and clinical studies In mice and ... activity of these ligands in this assay Atacicept and BCMA-Ig neutralized the activity of BLyS, APRIL, and heterotrimers in the TACI-Jurkat assay (Figure 3b) As expected, BAFF-R-Ig only neutralized ... The reduced potency of the heterotrimer ligands in the primary human B cell-proliferation assay compared with the homotrimeric BLyS may be explained by the predominant expression on circulating...

Báo cáo y học: " Pro/con clinical debate: The use of prone positioning in the management of patients with acute respiratory distress syndrome" potx

... especially in the early phase of illness [3] Disappointingly, however, in the only randomized, controlled study of proning yet published, hours of prone positioning did not influence mortality in the ... II Proning may benefit the most seriously ill subset of patients with acute respiratory distress syndrome Those in the quartile with the highest Simplified Acute Physiology Score II (SAPS II) have ... the ‘rule of rescue’ Intensivists feel obliged to offer some therapy, any therapy, to a patient in imminent danger of dying [16] As is often the case in critical care, a therapy that looks great...

Báo cáo y học: "Pro/con clinical debate: Are steroids useful in the management of patients with septic shock" ppt

... steroids are not useful in the management of septic shock Katherine G Craig and Keith R Walley The debate surrounding the use of corticosteroids in septic patients has continued for over 30 years ... reduction of almost 30% in patients with septic shock [9] The survival benefit of combination therapy was significant only in patients with blunted response to ACTH stimulation However, this may be ... adrenal insufficiency should be treated At this point in time there is not sufficient evidence to guide clinical practice We therefore not advocate use of steroids in this clinically improving patient...

Báo cáo y học: "Pro/con clinical debate: Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis" ppt

... recently used intravenous and enteral antibiotics (including amphotericin) to achieve decontamination of the gastrointestinal tract for the purpose of possibly decreasing bacterial inoculation of the ... antibiotics are not important in the management of patients with pancreatitis with evidence of pancreatic necrosis Lorne H Blackbourne and Stephen M Cohn Limiting prophylactic antibiotic use in severe pancreatitis ... intravenous antibiotics in the treatment of patients with severe pancreatitis, even in the setting of pancreatic necrosis The few prospective studies that exist investigating antibiotic use in severe pancreatitis...

Báo cáo y học: " Pro/Con Debate: Does recombinant factor VIIa have a role to play in the treatment of patients with acute nontraumatic hemorrhage" ppt

... mortality, with increased incidence of respiratory failure and renal failure as well as multiple organ dysfunction FVIIa has efficacy in restoring hemostasis Additionally, early administration ... continues to hemorrhage Administration of FVIIa is certainly warranted in this patient Life-threatening hemorrhage and coagulopathy in critical care patients carries significant morbidity and ... Rossaint R, Axelsen M, Kluger Y; NovoSeven Trauma Study Group: Recombinant factor VIIa as adjunctive Therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled,...

The management of patients with venous leg ulcers: Audit Protocol ppt

... with age Strength of evidence II 10 The management of patients with venous leg ulcers Assessment 2.2 Management of Patients with Venous Leg Ulcers The records show that patients with venous leg ... 1995) Strength of the evidence II The management of patients with venous leg ulcers Assessment 2.1 Assessment of Patients with Leg Ulcers The records show that the measurement of ABPI has been ... non-members: £4.50 The management of patients with venous leg ulcers Contents Introduction Why an audit of patients with leg ulcers Background of national sentinel audit What is included in the protocol...

báo cáo hóa học:" A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control study" pdf

... were associated with survival of severe sepsis when analyzed separately as well as analyzed as a haplotype Especially in the sub group of patients ≤60 years old and in patients with non-abdominal ... 0.052 Data are presented as mean and range of values death due to severe sepsis compared to patients without allele CATT7 The concomitance of the -173 allele C and the -794 allele CATT7 as a haplotype ... functional In the sepsis patient sub groups female and male patients as well as patients with age ≤60 years and in patients with non-pulmonary or non-abdominal focus the haplotype was associated with...

Báo cáo y học: " State of the Art: Why do the lungs of patients with cystic fibrosis become infected and why can''''t they clear the infection?" pps

... CF become infected? And why they not clear these infections? Why CF patients become infected? Mechanical factors In the lung, the CFTR channel is found in surface airway epithelial cells and the ... mucociliary escalator in the non -cystic fibrosis and cystic fibrosis (CF) airways In the non-CF airway (Fig 2A), where the depth of the periciliary fluid is normal, islands of mucus float on top and ... from the distal airspaces of the lung J Gen Physiol 2002, 119:199-207 Bubien JK: CFTR may play a role in regulated secretion by lymphocytes: a new hypothesis for the pathophysiology of cystic fibrosis...

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