Synthesis and biological evaluation of natural products and their analogs as new cancer chemotherapeutic agents
Synthesis and biological evaluation of natural products and their analogs as new cancer chemotherapeutic agents
... SYNTHESIS AND BIOLOGICAL EVALUATION OF NATURAL PRODUCTS AND THEIR ANALOGS AS NEW CANCER CHEMOTHERAPEUTIC AGENTS FANG ZHANXIONG (B.Sc.(Hons.) NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF ... production of a large number of analogs with the basic template.56 Epothilone D has shown to be at least as cytotoxic as paclitaxel against a range of cancer cell lines and one of 15 the analogs has ... as anticancer agents due to their high selectivity against A549 cells In Chapter 3, the synthesis of lignan natural products as potential anti-tumor agents was described After the synthesis of...
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Báo cáo khoa học: Natural polyphenols as proteasome modulators and their role as anti-cancer compounds doc
... decaffeinated black tea II I–II I I Phase I–II Phase I–II Phase II Phase Phase Phase Phase Tea polyphenols and theaflavins III III I–II II II II II II II Phase II Phase II Phase II FEBS Journal 275 (2008) ... proteins, activation of caspase and caspase 7, and cleavage of poly(ADP-ribose) polymerase The inhibition of proteasome activity by these fruit or vegetables may contribute to their cancer preventative ... therapy [16,22–24] The proteasome The proteasome is a multi-catalytic protease complex found in prokaryotic cells and in the cytoplasm and nucleus of all eukaryotic cells, and is the major nonlysosomal...
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design, synthesis, and biological evaluation of new anti-cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of chagas
... Evaluation of New Anti-cancer Nitrogen-Containing Combretastatins and Novel Cysteine Protease Inhibitors for the Treatment of Chagas Rogelio Siles Mentor: Kevin G Pinney, Ph.D In an effort to combat ... Derivatives of Combretastatins A-1 and A-4 66 Synthesis of Cold Precursors of Radio-labeled Combretastatins CA-1 and CA-4 70 Synthesis of OXi8007 and a Nitrogen-Based Indole 75 Biological and Biochemical ... Biochemical Evaluation of Cysteine Protease Inhibitors: Novel Compounds for Chagas Disease Treatment 143 Introduction 143 Background 144 Chemotherapy of Chagas Disease 148 Chapter Seven: Materials and...
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Synthesis and biological evaluation of 2 substituted benzimidazole derivatives
... time in second (Mean ± SEM) 0h 2h 3h 4h 1.56 ± 0.16 2. 16 ± 0.16 2. 0 ± 0 .25 2. 16 ± 0.16 2. 0 ± 0 .25 2. 0 ± 0 .25 1.61 ± 0.30 2. 16 ± 0.30 2. 0 ± 0 .25 2. 16 ± 0.16 2. 0 ± 0 .25 2. 16 ± 0.16 Control Std 3a 3b ... 14.38; found C 57 .29 , H 3.65, N 14.45 Synthesis and biological evaluation of 2- substituted benzimidazole derivatives 2. 2 .2. 2 (1H-Benoimidazol -2- ylmethyl)- (2, 3-dichloro-phenyl)amine (3b) Light ... MS: 26 8 [M+]; Anal calcd for C14H12N4O2 (26 8): C 62. 68, H 4.51, N 20 .88; found C 62. 74, H 4.49, N 20 .78 2. 2 .2. 10 (1H-Benzimidazol -2- ylmethyl)-(4-iodo-phenyl)-amine (3j) Colorless powder; m.p .22 1 22 3...
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Part i synthesis and biological evaluation of phosphoglycolipid PGL1 analogues part II synthesis and biological evaluation of andrographolide analogues
... PART I SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOSPHOGLYCOLIPID PGL1 ANALOGUES PART II SYNTHESIS AND BIOLOGICAL EVALUATION OF ANDROGRAPHOLIDE ANALOGUES HADHI WIJAYA (BSc (Hons.) NUS) A THESIS ... CONTENTS iv SUMMARY vii LIST OF TABLES ix LIST OF FIGURES xi LIST OF SCHEMES xv LIST OF ABBREVIATIONS xvii CHAPTER INTRODUCTION 1.1 Overview 1.2 Definition, Classification and sources of Natural Products ... treatment of various diseases In this thesis, the synthesis and biological evaluation of analogues of two natural products are presented In Chapter 2, the synthesis and biological evaluation of phosphoglycolipid...
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Synthesis and biological evaluation of isoindigo derivatives as anti proliferative agents
... functionalized isoindigos as antiproliferative agents, the aim of this thesis was to investigate medicinal chemistry approaches towards the design and synthesis of functionalized isoindigos with ... of isoindigos without compromising biological activity 1.5 Biological properties of functionalized isoindigos 1.5.1 Mode of action of meisoindigo Meisoindigo is the most widely investigated of ... understanding of the isoindigo scaffold and 19 to provide an objective assessment of its potential as a source of potent and drug-like compounds 20 Chapter 2: Functionalized isoindigos as cyclin-dependent...
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Solid phase synthesis and biological evaluation of 1, 3, 5 triazine derivatives
... 1,3 ,5- Triazine Derivatives 11 1.2.2 Synthesis of 1,3 ,5- Triazine Derivatives 14 1.2.2.1 Solution phase synthesis of 2,4,6-trisubtituted -1,3 ,5- triazine 14 1.2.2.2 Solid- Phase Synthesis of 1,3 ,5- Triazine ... 65 3.4 Synthesis of 1,3 ,5- triazine Analogs via Guanidium Azolides 80 3 .5 Synthesis of 1,3 ,5- traizine-2,4-diones 3-17 81 3 .5. 1 Solution -Phase synthesis of 3-17 81 3 .5. 2 Solid- Phase Synthesis of ... the synthesis of 1,3 ,5- triazine, 7476 this section will concentrate on the recent solution -phase and solid- phase syntheses of the 1,3 ,5- triazine derivatives 1.2.2.1 Solution phase synthesis of...
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Design, synthesis and biological evaluation of inhibitors of flavivirus NS2B NS3 protease
... the thesis involves the design, synthesis and biological evaluation of inhibitors of Dengue and West Nile virus NS2B- NS3 protease For the design of dengue NS2B- NS3 protease inhibitors, we were inspired ... DEN2 NS2b- NS3 protease 60 Chapter 4: Synthesis and biological evaluation of small molecule inhibitors of West Nile Virus NS2B/ NS3 Protease 4.1 63 4.1.1 Chemistry 65 4.1.2 4.2 Introduction Biological ... kD VTA↓G, Unknown NS2B 14 kD RR↓S, NS2B- NS3 Protease NS3 70 kD RR↓S, NS2B- NS3 Protease NS4A 16 kD RR↓G, NS2B- NS3 Protease NS4B 28 kD VAA↓N, Signalase NS5 103 kD RR↓G, NS2B- NS3 Protease Function/enzymatic...
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Part 1 total synthesis and biological evaluation of antillatoxin and fragments part II synthetic studies towards the total synthesis of cytochalasans and tuberostemonine
... PART I TOTAL SYNTHESIS AND BIOLOGICAL EVALUATION OF ANTILLATOXIN AND FRAGMENTS PART II SYNTHETIC STUDIES TOWARDS THE TOTAL SYNTHESIS OF CYTOCHALASANS AND TUBEROSTEMONINE APPENDIX ... Biological Evaluation of Antillatoxin and Fragments 1. 1 Historical Background 1. 2 Previous Synthetic Studies 1. 3 Our Retrosynthetic Analysis of Antillatoxin 11 1. 4 Results and Discussion 15 1. 5 ... 1. 5 Biological Evaluation of Antillatoxin and Fragments Using Zebrafish Embryo 30 1. 6 Conclusion 44 1. 7 Experimental 45 Part II Chapter 2: Synthetic Studies Towards the Total Synthesis of Cytochalasans...
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Báo cáo hóa học: " One-Pot Synthesis of Biocompatible CdSe/CdS Quantum Dots and Their Applications as Fluorescent Biological Labels" doc
... doi:10.1007/s11671-010-9774-z Cite this article as: Zhai et al.: One-Pot Synthesis of Biocompatible CdSe/CdS Quantum Dots and Their Applications as Fluorescent Biological Labels Nanoscale Res Lett 2011 ... temperature, and 19 mg of Se powder was added Finally, the mixture was heated to 240°C and kept for a certain period of time such as 1, 5, 60, and 120 Synthesis of CdSe/CdS QDs As sulfur source, ... monochromaticity of the fluorescence but also the quantum yields of the QDs In our case, the quantum yields of the as- synthesized CdSe cores are around 2–3% In order to passivate their surface trap sites and...
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consumer categorization and evaluation of ambiguous products
... understanding of how consumers process and evaluate ambiguous products The success of some ambiguous products and the failure of others have added to the confusion surrounding these products and consumer ... issues associated with consumer understanding and evaluations of ambiguous products and to suggest ways by which marketers can render consumer evaluations of their ambiguous products more favorable ... This dissertation examines how evaluations of ambiguous products can be influenced by controlling the categorization of such products Ambiguous products refer to products that may be categorized...
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Activity based chemical proteomics profiling of natural products and drug like small molecules
... describe the design and synthesis of OrlistatTM -like natural product -based probes (Chapter 2, & 4), K11777 -like drug candidate -based probes (Chapter 5) and azanitrile-containing small molecules (Chapter ... 1.2 Activity- Based Protein Profiling (ABPP) 1.2.1 Introduction 1.2.2 Activity- Based Probe Design 1.2.3 Bioorthogonal Chemistry in ABPP 10 1.2.4 Application of ABPP for Target ID of Natural Products ... Application of ABPP for Target ID of Natural Products Natural products, and their derivatives and mimics, have rendered an enormous contribution to the treatment of diseases such as infentions and cancers...
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Chemistry of calophyllum wallichianum, scapania undulata, plagiochila colorans and biotransformation of natural products
... 1.2 Natural Products 1.3 Biosynthesis of Natural Products 1.4 Natural Products in Modern Drug Discovery Chapter Chemistry of Calophyllum wallichianum 12 14 2.1 Introduction 14 2.2 Results and ... general background of natural products chemistry Chapter two to chapter four concern the chemical studies of three plants: Calophyllum wallichianum, Scapania undulata and Plagiochila colorans The last ... Calophyllum wallichianum, Scapania undulata, Plagiochila colorans, Biotransformation List of Tables Table 2-1 1H, 13C NMR Data and HMBC Correlations of 74 Table 3-1 1H, 13C NMR Data of 117 and 1H...
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Evaluation of thymoquinone for cytotoxic activity against human breast cancer cell lines and tumor xenograft in nude mice
... protein expression of several genes of interest in the tumor tissues was examined and these findings were compared with those from cell line studies The antitumor effect of the combination of TQ ... determining the anticancer activities of TQ and its possible mechanisms of action in breast cancer cells, our next interest was to examine these effects in an animal model Breast tumor xenograft ... number and size of aberrant crypt foci in 1,2-dimethyl hydrazine-induced colon cancer in mice (Gali-Muhtasib et al., 2008b) Oral administration of TQ inhibited forestomach tumor incidence and multiplicity...
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Synthesis of metal oxide nanostructures and their applications as lithium ion battery anodes
... IONP@PC and IONP@mC-600 Insets of C and F: SAED patterns of IONP@PC and IONP@mC-600 95 Figure 6-4: Particle size distributions of (A) IONP@PC and (B) IONP@mC-600 96 Figure 6-5 TEM images of IONP@mC-600 ... iron oxides and lithium was in the 1980s.[51] However, the nature of the reaction was not clear until J M Tarascon and his coworkers reported the conversion reaction between transition metal oxides ... as TiO2[30] and Li4Ti5O12[17]; (2) alloying based materials, such as Si,[31] Ge,[32] Sn,[33] and their oxides/composites; (3) conversion reaction based materials, including transition metal oxides,[34]...
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Từ khóa: biochemical and biological evaluation of cc 1065 analogs and conjugates with polyamidesrecent trends in the use of natural products and their derivatives as potential pharmaceutical agentshighlights of research on plant derived natural products and their analogs with antitumor anti hiv and antifungal activityskin tissue engineering part ii — the in vitro evaluation of natural and synthetic 3 d matrices as dermal substratesevaluation of natural languageeagles evaluation of natural language processing systemsevaluation of natural language processing systemsevaluation of natural language processingpreparation of metal loaded porous carbons and their use as a highly active catalyst for reduction of nitric oxide noeffects of natural products on laboratory valuesrole of the european agency for the evaluation of medicinal productsvector systems for expression of natural productsscreening of natural productscyanobacteria and their toxins as agents of bioterrorismviral safety evaluation of biotechnology products derived from cell lines of human or animal originBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếThơ nôm tứ tuyệt trào phúng hồ xuân hươngBT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ