CHARACTERIZING ROLES OF ANNEXIN 1 IN BREAST CANCER DEVELOPMENT BY MASS SPECTROMETRY BASED QUANTITATIVE PROTEOMICS
CHARACTERIZING ROLES OF ANNEXIN 1 IN BREAST CANCER DEVELOPMENT BY MASS SPECTROMETRY BASED QUANTITATIVE PROTEOMICS
... tagging for relative and absolute quantification IAA Iodoacetamide ICAT Isotope-coded affinity tagging K0R0 12 C 614 N2-lysine and 12 C 614 N4-arginine K8R10 13 C 615 N2-lysine and 13 C 615 N4-arginine ... Annexin 1. 2 .1: Structure of ANXA1 ANXA1 is one of the members of the annexin superfamily of 13 members (A1-A13) All members of this superfamily have the same principal property of binding to negatively-charged ... System, Singapore on 30 January 2 013 This work was presented as a poster in Proteomics Forum held in Berlin, Germany from 17 – 21 March 2 013 xvii Chapter 1: Introduction 1. 1: Breast cancer Breast cancer...
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Báo cáo khoa học: "An ultrasonographic evaluation of skin thickness in breast cancer patients after postmastectomy radiation therapy" docx
... majority of patients assessed were those following conservative surgery and irradiation Correlations of Acute skin scoring (RTOG) and fibrotic skin thickness Skin reactions occurring within a time interval ... means of assessing late skin toxicity in postmastectomy breast cancer patients after radiation therapy Huang et al [25] has demonstrated that skin thickness measured via ultrasonic imaging proved ... edema in 32 postmastectomy breast cancer patients who received full course of radiation therapy in our department This is one of the few studies of its kind on postmastectomy breast cancer patients...
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Báo cáo y học: " Identification of fusion genes in breast cancer by paired-end RNA-sequencing" potx
... ZNF704 14 14 Yes Yes No No Yes 3 Yes Yes Yes SK-BR-3 CYTH1 SK-BR-3 DHX35 17 20 EIF3H ITCH 20 38 2 Yes Yes Yes No Yes Yes Yes SK-BR-3 NFS1 20 PREX1 20 Yes KPL-4 BSG 19 NFIX 19 22 14 Yes No Yes KPL-4 ... number of validated expressed fusion genes reported in breast cancer cells so far This indicates the power of transcriptomic profiling by next-generation sequencing in that it can rapidly identify ... study, we describe the identification of 27 fusion genes from breast cancer samples using paired-end RNA-seq combined with a novel bioinformatic strategy This study therefore significantly increases...
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báo cáo khoa học: " Overexpression of Pim-1 in bladder cancer" pdf
... understand of the clinical significance of Pim-1 Figure Expression profile of Pim-1 in bladder cancer cell lines A Expression profile of Pim-1 in bladder cancer cell lines Cell lysate from five bladder ... Pim-1 in bladder cancer cell lines In order to further demonstrate the role and function of Pim-1 in bladder cancer, the expression level of Pim-1 was validated in bladder cancer cell lines using ... further classified into Noninvasive (Tis, Ta and T1) and invasive (≥T2) groups The data (Table 2) shows that the staining intensity of Pim-1 is increased in invasive bladder carcinoma samples (95%)...
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báo cáo khoa học: " Microarray-based analysis of microRNA expression in breast cancer stem cells" doc
... be one of the causes of high expression of the drug-metabolising enzyme CYP1B1 in cancerous tissues [14] Finally, as a tumor suppressor in breast cancer cells, miR-17-5p regulates breast cancer ... Ras-GAP binding proteins (G3BP) Oncogene 2007, 26(29):4209-4215 27 French J, Stirling R, Walsh M, Kennedy HD: The expression of Ras-GTPase activating protein SH3 domain-binding proteins, G3BPs, in ... Cell Death inhibits breast cancer cell invasion by increasing Tissue Inhibitor of Metalloproteinases-2 expression Breast Cancer Res Treat 2009, 114(2):203-209 37 Frankel LB, Christoffersen NR,...
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Báo cáo y học: "Inactivation of HIV-1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS)" pot
... with HIV-1 has been examined We hypothesize that treatment of expressed breast milk with this microbicide will effectively inactivate HIV-1 in breast milk Efficiency of viral inactivation in breast ... against HIV-1 in breast milk The virucidal activity of SDS against cell-free HIV-1 in breast milk was assessed by adding high titer HIV-1 IIIB to breast milk obtained from apparently healthy donors ... of using microbicides to treat HIV-1 infected breast milk to prevent MTCT of HIV-1 The alkyl sulfate family of microbicides are agents with both surfactant and protein denaturant properties The...
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Role of stathmin 1 in colorectal cancer metastasis and chemo resistance
... 11 3 6 .1. 4 Mutagenesis 11 3 6 .1. 5 6.2 HCT 116 and E1 cell lines 11 2 Transfection 11 4 Cell-based assays 11 5 6.2 .1 6.2.2 Wound healing 11 5 6.2.3 ... Stathmin- 1 1. 2 .1 The Stathmin family 1. 2.2 STMN1 in microtubule regulation 10 1. 2.3 STMN1 in cell cycle regulation 12 1. 2.4 STMN1 in cancer 14 ... Conclusion and future work 10 7 Chapter Materials and methods 11 0 6 .1 Cell lines and constructs 11 2 6 .1. 1 6 .1. 2 Preparation of whole cell lysate 11 2 6 .1. 3 STMN1 KD and...
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THE ROLE OF ANNEXIN 1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES
... 11 6 11 9 4 .1 The role of Annexin- 1 in the regulation of inflammatory stress 11 9 response 4.2 Conclusion 14 4 4.3 Limitations of the study 14 5 4.4 Future work 14 6 Bibliography 14 8 Summary Annexin- 1 ... for investigation of the basis of the inflammatory stress response The aims of this study are thus, 1) To determine the role of ANXA1 in the regulation of the inflammatory response upon induction ... (ANXA1) 27 1. 6 .1 Functions of ANXA1 29 1. 6 .1. 1 ANXA1 in inflammation 29 1. 6 .1. 2 ANXA1 in cellular proliferation, differentiation and apoptosis 31 1.6 .1. 3 ANXA1 in cancer 33 1. 6 .1. 4 ANXA1 in leukocyte...
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The role of prion protein in breast cancer cell metabolism
... of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer metabolism ... higher in normal breast cell line (MCF10A) than breast cancer cell lines (MCF7, SK-BR-3, and MDA-MB-231) Proliferation rate in breast cancer cell lines Up-regulation of p53 in breast cancer cell lines ... highest in terms of mortality rate (WHO, 2008), while according to the Singapore Cancer Registry, in 17 women will develop breast cancer in her lifetime in Singapore The risk of getting breast cancer...
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Paradoxical roles of the immune system during cancer development docx
... that the adaptive immune system differentially modulates de novo cancer development in an organ-dependent and aetiology-dependent manner The paradoxical influence of the adaptive immune system during ... to be resolved with these powerful approaches is how therapeutically manipulating one arm of the immune system affects the anticancer or cancer- promoting properties of the other For example, Hamerman, ... history of alcohol and tobacco use66,67 On the other hand, the RR for the most common non-viral-associated solid tumours of epithelial origin is decreased in immune- suppressed patients; some of these...
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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
... [52,53] Pharmacological targeting of matrix metalloproteinases On the basis of the pivotal roles that MMPs and ADAMs play in several steps of cancer progression, the pharmaceutical industry has invested ... threonine and tyrosine kinases, thus contributing to cancer development [11] Roles of MMPs in cancer progression During development of carcinogenesis, tumor cells participate in several interactions ... although their main roles focus on ectodomain shedding and nonproteolytic functions, such as binding to adhesion molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine...
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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
... processing unit Fig E2 and E3BP domains and their binding interactions E2 subunit domains: L1, N-terminal lipoyl domain; L2, inner lipoyl domain; B, E1 binding domain; I, oligomer-forming, acetyl-transferase-catalyzing ... L2 In a second region at the other end of the L2 domain, mutation of glutamates 16 2, 17 9 and 18 2, and glutamine 18 1 greatly reduces binding Indeed, substitution of alanine or glutamine for Glu182 ... acetyl-transferase-catalyzing inner domain E3BP domains: L3, N-terminal lipoyl domain; B, E3 binding domain; I, inner domain which associates with the inner domain of E2 Dotted connections indicate binding interactions...
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báo cáo hóa học:" Mass spectrometry-based serum proteome pattern analysis in molecular diagnostics of early stage breast cancer" pdf
... Data Processing and Statistical Analysis The preprocessing of data that included averaging of technical repeats, interpolation of missing or non-aligned points, binning of neighboring points to reduce ... resolution of the analyzer operating in the linear mode or might result in overlapping of ions originating from protein/ peptides of very similar molecular masses In addition, because of technological ... aim of constructing a putative marker useful in early diagnosis of breast cancer, we decided to combine features of the serum proteome pattern identified by MALDI-ToF MS analysis and the level of...
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Từ khóa: role of oxidative stress in breast canceratf creb family of transcription factors in breast cancerthe role of caveolin 1 in skin cancerclassification of amyloidosis by mass spectrometry based proteomicsthe roles of ras family small gtpases in breast cancerpost transcriptional regulation of proto oncogene c fms in breast cancerbreast cancer may originate in utero the importance of the intrauterine environment for breast cancer developmentindispensable roles of cyclooxygenase 1 and 2 in endothelium dependent contractionsapplication of a gis based statistical method to assess spatio temporal changes in breast cancer clustering in the northeastern united statesthe effect of systemic chemotherapy on minimal residual disease in the blood and bone marrow of patients with inflammatory breast cancerpet ct in breast cancer their combination for improving the prediction of disease relapsevà cs comparison of er pr and her 2 neu c erb b 2 reactivity pattern with histologic grade tumor size and lymph node status in breast cancer asian pac j cancer prev 2008 oct dec 9 4 553 6roles of security manager in an organizationa mathematical model of breast cancer development local treatment and recurrencethe roles of discount house in financial sector of nigerian economyNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP