Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
... develop and apply computational methods and tools for ADR and toxicity prediction The methods developed in this work are potentially useful for development and application of QSAR models as well ... complex, time consuming and resource intensive Toxicity is one of the primary reasons for the failure of drug candidates in later stages of drug development Moreover, adverse drug reaction (ADR) during ... drug development and safety assessment 1.2 QSAR studies for ADR and toxicity prediction To deliver promising drug candidates to reach the late stage of drug development with a higher chance of...
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Báo cáo y học: "Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon" ppsx
... (and Lys) tend to be over- High density IJISS DNA arrays have been developed for global analysis of Streptomyces gene expression and transcription factor binding The HspR regulatory system of S ... against the test arrays and the probe performance was scored using the following equations Firstly the Cy3 and Cy5 background-subtracted signals, designated 'g' and 'r', respectively, obtained by feature ... chaperone and protease production It is envisaged that these arrays will find widespread use in systems level analysis of Streptomyces coelicolor biology Materials and methods Streptomyces strains and...
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Development and application of a high throughput assay for discovery of starch hydrolase inhibitors
... αglucosidase and α-amylase can significantly reduce the post-prandial increase in blood glucose after a meal, with starch as the major calorie intake The apparent advantage of the starch hydrolase inhibitors ... linear range of gelatinized starch Table Accuracy and precision of the high- throughput method Table IC50 and acarbose equivalence of inhibitors obtained by starch hydrolases Table Estimation of ... of starch involves saliva α-amylase, pancreatic αamylase, and the small intestinal brush border α-glucosidase, that is, maltaseamyloglucosidase and sucrase-isomaltase [19, 67] Determination of...
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Development and application of novel capillary electrophoresis techniques for analysis of DNA fragments and organic pollutants
... focused on the analysis of DNA fragments; and the second part (chapter and chapter 5) focused on the analysis of organic pollutants Several novel capillary electrophoresis (CE) techniques had ... various applications, the CE applications in DNA analysis and monitoring of pollutants are of significant importance 1.3.1 CE Application in DNA Analysis DNA separation by CE has been the subject of ... for on-site analysis of various pollutants at trace level CE is found to be a versatile analytical tool for the analysis of DNA as well as pollutants Combination of DNA analysis and environmental...
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Application of computational intelligence for faulty detection and diagnosis of induction motors and electromechanical systems
... automatic software platform for fault detection and diagnosis of induction motors and electromechanical systems, analyzing vibration data features and studying and comparing related algorithm, and targeting ... APPLICATION OF COMPUTATIONAL INTELLIGENCE FOR FAULT DETECTION AND DIAGNOSIS OF INDUCTION MOTORS AND ELECTROMECHANICAL SYSTEMS ZHANG YIFAN B Eng (Hons.), Tianjin ... SVM and how it is applied in the case of induction motors and electromechanical systems condition detection Chapter presents and discusses results of the proposed method of condition detection and...
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Tài liệu Báo cáo khoa học: Application of a fluorescent cobalamin analogue for analysis of the binding kinetics A study employing recombinant human transcobalamin and intrinsic factor pdf
... Expression and purication of human recombinant IF and TC The recombinant Cbl binding proteins and their fragments were isolated from plants and yeast as described earlier [9,17] Preparation of the unsaturated ... Fedosova NU, Nexo E & Petersen TE (2002) Comparative analysis of cobalamin binding kinetics and ligand protection for intrinsic factor, transcobalamin, and haptocorrin J Biol Chem 277, 99899996 Cannon ... uorophore, as was expected from the crystallographic data for TCCbl complex [16], and the binding- dissociation curves of CBC and Cbl were identical (Figs 2B,4B Application of a uorescent Cbl analogue and...
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Fabrication and application of silicon nanowire transistor arrays for biomolecular detection
... and encapsulated using glass rings and a biocompatible epoxy glue Please cite this article in press as: X.T Vu, et al., Fabrication and application of silicon nanowire transistor arrays for biomolecular ... et al., Fabrication and application of silicon nanowire transistor arrays for biomolecular detection, Sens Actuators B: Chem (2009), doi:10.1016/j.snb.2008.11.048 G Model SNB-11150; No of Pages ... Silicon nanowire arrays for label-free detection of DNA, Anal Chem 79 (9) (2007) 3291–3297 Please cite this article in press as: X.T Vu, et al., Fabrication and application of silicon nanowire transistor...
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Preparation, characterization and application of heterogeneous solid base catalyst for biodiesel production from soybean oil
... performances of these acid catalysts are still inferior compared with the base catalysts For this reason, a wide variety of solid bases have been examined for transesterification reactions for biodiesel ... of used vegetable oils using the heterogeneous WO3/ZrO2 catalyst for production of biodiesel Bioresour Technol 2010;101:S59e61 [10] Lou WY, Zong MH, Duan ZQ Efficient production of biodiesel from ... many similarities, and therefore, Table e Comparison of properties of the obtained biodiesel and the standards of biodiesel in china, Europe and the United States Item Obtained biodiesel À1 China...
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Development of computational methods for the rapid determination of NMR resonance assignment of large proteins
... determination is the spectral assignment procedure This involves sequence-specific resonance assignment of NMR signals and the assignment of NOESY spectra Resonance assignment forms the basis for characterizing ... obtain the assignments of the Cα and CO of the same residue Then, the CO frequency is used to obtain assignments for the HN and 15N of residue (i+1) with the HNCO experiment Finally, the NH and ... applications for solution NMR 1.3.2 TROSY triple -resonance experiments for resonance assignments of large proteins NMR experiments provide a set of unique combinations of neighboring resonance spin...
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Application of computational intelligence in biological sciences
... and constraints, the searching of these probes using traditional searching methods is computationally intensive Our approach is to use make use of computational intelligence techniques, in this ... target In a probe, if one section of the ORF is 31 E n d -p o in t of s u b -s e q u e nc e Chapter Finding Probes of Yeast Genome using ES Start-point of sub-sequence Figure 3.2 The spread of the ... optimization problems, it should incorporate the information of constraint violation into the fitness value because all information of the quality of an individual is determined by its fitness value...
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báo cáo khoa học:" Study on the clinical application of pulsed DC magnetic technology for tracking of intraoperative head motion during frameless stereotaxy" pdf
... 2:10 http://www .head- face-med.com/content/2/1/10 Figure1 Type B fixation of the head Type B1 fixation of the head (A) Patient positioned on the right side for resection of a left frontal metastasis ... chosen on the basis of the image data Accuracy of frameless stereotaxy with the DRF in the clinical application The overall precision of the DRF in clinical use is affected by various factors These ... all other procedures, continuous tracking of head motion ensures automatic correction of spatial distortion with mechanical alteration of the head position With a special dental cast for the oral...
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application of committee k-nn classifiers for gene expression profile classification
... APPLICATION OF COMMITTEE k-NN CLASSIFIERS FOR GENE EXPRESSION PROFILE CLASSIFICATION Manik Dhawan Thesis Approved: Accepted: _ Advisor Dr Zhong-Hui Duan _ Dean of ... informative genes to feed a series of k-NN classifiers each having a different architecture Recruit the top performing k-NN classifiers to form a committee Evaluate the k-NN classifier based committee ... 1.6 Objectives of the study and outline of the thesis The specific objectives of the study were to: Extract the most informative genes from a selection of gene expression profiles of leukemia patients...
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application of real coded genetic algorithm for ship hull surface fitting with a single non-uniform b-spline surface
... Pukyong National University August 2009 Application of Real Coded Genetic Algorithm for Ship Hull Surface Fitting With a Single Non-Uniform B-spline Surface A dissertation by Tat-Hien Le Approved ... data of container ship (included vertices and knot values) 93 viii Application of Real Coded Genetic Algorithm for Ship Hull Surface Fitting With a Single Non-Uniform B-Spline Surface Tat-Hien ... the advantages of single rectangular B-spline surface in ship hull form design 3.1 Non-Uniform B-Spline Surface Fitting Application in Ship Hull Design The ship hull can be generated in one of...
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Study on application of high k dielectric materials for discrete charge storage memory
... investigation Another exploration of high- k dielectrics for SONOS type memory is to use highk dielectrics as charge storage layer instead of nitride The potential advantages of high- k charge storage ... the formation of NCs, device integration, and the memory performance The implementation of high- k dielectric instead of SiO2 brings additional advantage to NC memory in that the use of high- k dielectric ... STUDY ON APPLICATION OF HIGH- K DIELECTRIC MATERIALS FOR DISCRETE CHARGE STORAGE MEMORY WANG YING QIAN (M Eng., Tsinghua University, China) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...
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Từ khóa: retrospective regional risk assessment predictions and the application of a monte carlo analysis for the decline of the cherry point herring stockapplication of matrix methodsapplication of chemical methods to the pre treatment of samples before chromatographic separationapplication of common core state standards for english language learners— application of the runge kutta method for solving the initial value problemsapplication of iso 9001 industrial standard to herbal drug regulationapplication of intraoperative indocyanine green angiography for cns tumors results on the first 100 casesdevelopment and partial evaluation of evidence based multilanguage search tools for medline pubmedsupport the development implementation evaluation maintenance and dissemination of informatics methods and approachesmethods and tools for identification of physiologic systemsmethods of evaluation of fetal development and well beingthe history development and testing of forensic risk assessment toolsdevelopment and application of genomic models for large crop plant genomesmethods techniques and tools for the on line study of the writing processan application of ftir and 13c nmr spectroscopy on examining of artificial coalification process and developmentNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDETrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíBT Tieng anh 6 UNIT 2Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP