Gene expression changes in the brainstem and prefrontal cortex in a mouse model of orofacial pain
Gene expression changes in the brainstem and prefrontal cortex in a mouse model of orofacial pain
... microarray-based approaches to examine gene expression and miRNA changes in the brainstem and prefrontal cortex in a mouse facial carrageenan injection model of orofacial pain At the brainstem level, increased ... Inflammatory pain Tissue injury initiates an inflammatory response that induces pain This type of pain is known as inflammatory pain Inflammatory pain is due mainly to the action of prostaglandins ... demonstrated the involvement of both brainstem and prefrontal cortex in pain, in a mouse model of orofacial pain The differentially expressed genes in different region of the brain i.e brainstem and...
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Gene expression changes in the brainstem in a mouse model of orofacial pain
... GENE EXPRESSION CHANGES IN THE BRAINSTEM IN A MOUSE MODEL OF OROFACIAL PAIN DR LUTFUN NAHAR NATIONAL UNIVERSITY OF SINGAPORE 2009 II GENE EXPRESSION CHANGES IN THE BRAINSTEM IN A MOUSE MODEL ... neuron in the sensory ganglion of cranial nerves VII, IX and X OROFACIAL PAIN The diagnosis and treatment of facial pain remains a great challenge for oral and maxillofacial surgeons The pain syndromes ... trigeminal neuralgia, atypical facial pain, and temporomandibular joint pain (Claeys et al., 1992) Facial pain has many causes, including idiopathic factors, trigeminal neuralgia, dental problems,...
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Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance docx
... of adenomatous polyposis coli (APC), somatostatin, carbonic anhydrase and tenascin C in the cerebellum (Figure 1a) and those of lysyl oxidase, carbonic anhydrase 4, enolase 3β and creatine kinase ... sensitive to thyroid hormone and the primary mode of T3 action is a direct influence on cardiac gene expression [20] Increased heart rate (tachycardia) and myocardial contractility are clinical features ... selection and data analysis All array data were deposited in the NCI-CIT microarray database [65] where Cy3 and Cy5 signals were median normalized and expression ratios (Cy5/Cy3) were calculated The...
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Role of central nervous system ceramides and free radicals in a mouse model of orofacial pain
... complicated because of the region’s density of anatomical structures, rich innervations and high vascularity Orofacial pain is defined by the American Academy of Orofacial Pain (AAOP) as pain conditions ... as brushing and touch, are painful (allodynia), and normally mild pain stimuli like pinprick are much more painful than usual (hyperalgesia) Hyperalgesia in the area of injury is also known as ... sensibility including touch and thermal sensation without pain, as well as to pain Hyperesthesia includes both allodynia and hyperalgesia Hyperpathia is defined as a painful syndrome characterized by an...
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Effects of central nervous system free fatty acids, prostaglandins and lysophospholipids on allodynia in a mouse model of orofacial pain
... infection and neoplasms Neuralgic pain is generally expressed in the facial area as idiopathic trigeminal neuralgia The ill-defined category of atypical oral and facial pain includes a variety of pain ... hyperalgesia, and in the area of normal tissue surrounding the injury site, as secondary hyperalgesia (c) Phase (Neuropathic Pain) These are abnormal pain states and are defined as pain initiated or caused ... have also indicated central involvement of excitatory amino acids in trigeminal nociception (Parada et al., 1997) Methods of Assessing Pain in Animals Pain research and therapy during the past...
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Gene expression profiling in a rat model of neurodegeneration
... effects, after intraperitoneal injection of KA in rats (Wilson et al 2005) and increased expression of genes related to neurodegeneration and astrogliosis after intraperitoneal KA-nicotine injection ... Model of Neurodegeneration _ CHAPTER GENE EXPRESSION ANALYSIS OF HIPPOCAMPUS IN KAINATE RAT MODEL OF NEURODEGENERATION 23 Chapter Gene Expression of Hippocampus in ... RNA quality was analyzed using an Agilent 2100 Bioanalyzer, and cRNA generated and labelled using the one-cycle target labeling method cRNA generated from each sample was hybridized to a single...
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Báo cáo y học: " Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa" docx
... microarray analysis Additional data file is a table listing highly ranked retinal miR target genes predicted using miRanda The miRNA array data are available at Array Express [58] using accession ... version of this paper Additional data file is a table listing retinal miR expression data from Exiqon microarray analysis Additional data file is a table listing retinal miR expression data from Ambion ... rett-testmedian expressionandhighlyin triplicate P 129, and miRanda month; analysis 1analysis are Exiqon c57, values analysis Log are using miRanda Student's t-test microarrayby P at predicted of retinal...
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Regulation of substance p and neurokinin 1 receptor expression in a mouse model of acute pancreatitis
... has been identified as a key proinflammatory mediator in experimental acute pancreatitis (AP) SP is a product of the preprotachykinin -A (PPTA) gene, and it binds mainly to neurokinin- 1 receptor ... either an aromatic or an aliphatic amino acid (Severini et al., 2002) Tachykinins are produced by three genes in mammals, namely preprotachykinin A (PPTA), preprotachykinin B (PPTB), and preprotachykinin ... Etiology and epidemiology of acute pancreatitis 1. 2.2 Mild vs severe acute pancreatitis 1. 2.3 Pathophysiology of acute pancreatitis 1. 2.4 Severe acute pancreatitis and pancreatitis...
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Báo cáo sinh học: "Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer" pdf
... Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S: Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil ... cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscript to BioMed Central and take full advantage ... vaccination with mGC8 cells and GM-CSF T cells generated from TVDLN at day nine after vaccination were polyclonally activated and expanded as described in the Methods section and tested for tumorspecific...
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The role of interferon gamma in regulating antigen specific CD8 t cell responses in a mouse model of influenza
... with both the avian and human strains of influenza This facilitates viral reassortment and the generation of novel 10 Chapter 1: Introduction human viral strains with the potential of transferring ... cells HAspecific antibodies form a solid correlate of protection against influenza provided that they match the virus causing the infection In contrast to the antibodies targeted to the HA head region, ... immunity takes days to be initiated and then for the response to peak In the interim, it is the innate immune response that combats viral replication in the initial phase of the infection, buying...
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Báo cáo y học: "Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain"
... (5’-GGCGUGUCUCUCU UACGAC-3”) SiRNAs targeting the cDNA sequence of rat TLR4 (GenBank accession NM_019178) were: 5’-CUACCAACAGAGAGGAUAU-3” (siRNA1 ), 5’-GUCUCAGAUAUCUAGAUCU-3’ (siRNA2 ), 5’-GAGCCGGAAAGUUAUUGUG-3’ ... tissues was significantly lower in the CCI group during the course of 255 TLR4 -siRNA treatment, indicating that intrathecal administration of TLR4 -siRNA significantly attenuated TLR4 induction in the ... CCI rats (Figure 3) Figure Inhibition of TLR4 signaling upon TLR4 -siRNA in CCI rats Either saline or 10μg of selected siRNA was administered intrathecally once daily for days as described in Materials...
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Báo cáo y học: " Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma" doc
... peptides including LANP, VD and KP in modulating lung inflammation In this report we show that overexpression of VD attenuates airway inflammation in a mouse model of allergic asthma The effects of ... determine airway resistance values and peak values obtained after each MeCh challenge were plotted [16] Modulation of lung inflammation by VD To test the effects of VD on airway inflammation, a separate ... down-regulated NPRA expression We have reported that NPRA plays a role in airway inflammation Knockout of NPRA in mice resulted in less lung inflammation [11] Inhibition of NPRA by small inferfering...
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Báo cáo y học: " GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma" ppt
... (s.e.m.) After log transformation, airway responsiveness to methacholine was statistically analyzed by a general linear model of repeated measurements (ANOVA) followed by a post hoc comparison ... characterized by AHR, induction of specific IgE and airway eosinophilia We show for the first time that AHR is dramatically increased by GITR triggering at the time of allergen challenge, resulting in a ... Respiratory Research 2009, 10:93 Background Allergic asthma is an inflammatory disease characterized by reversible airway obstruction, and is associated with airways hyperresponsiveness (AHR)...
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Báo cáo y học: "Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds)" pot
... data confirmed that Wlds reactivates dormant cell cycle pathways, pushing cells toward cell cycle re-entry rather than inhibiting it Role of Pttg1, NAD, and VCP pathways in mediating cell cycle ... SuperArray analysis as being upregulated by more than twofold The final portion of the graph shows similar increases in cell cycle proteins not included on the SuperArray plate, showing that increased ... Sameshima M, Matsuda Y, Kaneda S, Nagai Y, Yamao F, Seno T: Abnormal integrity of the nucleolus associated with cell cycle arrest owing to the temperature-sensitive ubiquitin-activating enzyme...
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Từ khóa: of epilepsy progression roles of growth hormone signaling in a mouse model of temporal lobe epilepsystep by step in situ hybridization method for localizing gene expression changes in the brain1β gene expression and vasogenic edema development in a porcine model of intracerebral hemorrhage pdfaeruginoasa induced gene expression changes in cf dc2 4 a mosaic expression pattern in a cross section of the intestinal villi b c and d mosaic expression patterns of either side of an intestinal villus that is located at the margin of the donor embryo s and host embryo s derivativesinvestigation of age specific behavioral and proteomic changes in an animal model of chronic ethanol exposure— relationship between h2s and no in a rat model of amitan k h kong s q yap p t h wong m l go y lam and c m low 5 substituted benzimidazole derivatives reduced infarct volume in a rat model of permanent cerebral ischemia in preparationexperience with op 1 in a rabbit model of lumbar fusionstnfα monoclonal antibodies combinatorial treatment inhibits autoimmune disease in a murine model of systemic lupus erythematosusproteomic methods for biomarker discovery in a rat model of alcohol steatosisantisense oligo mediated multiple exon skipping in a dog model of duchenne muscular dystrophybehavior in a drosophila model of fragile xcomparison of the gene expression changes of 25 differentially expressed genes in hcc using spotted microarray analysis and affymetrix genechip analysishxt3 and hxt7 gene expression is discordant with hxt3 and hxt7 protein expression in grr1δ cells left spot dilution assays were performed at various concentrations of glucose in the presence of the respiratory inhibitor antimycin a 3Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát hiện xâm nhập dựa trên thuật toán k meansThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíChuong 2 nhận dạng rui roBT Tieng anh 6 UNIT 2Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ