Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 1
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 1
... INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY NATIONAL UNIVERSITY OF SINGAPORE 2 011 INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE ... THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY (B SCI (HONS), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MICROBIOLOGY YONG LOO LIN SCHOOL OF MEDICINE ... DOCTOR OF PHILOSOPHY DEPARTMENT OF MICROBIOLOGY YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNIVERSITY OF SINGAPORE 2 011 ...
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Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 2
... regulation of transcription In this project we investigated the role of ubiquitin in the regulation of the heat shock gene HSP70B Through RNA interference of SKP1, a component of an ubiquitin ligase ... Role of Med21/hSrb7 in the Regulation of HSP70B 109 3.7 The Effect of the RNA Interference of Med21/hSrb7 and its Effects on Proteosomal Inhibition of HSP70B Induction 113 3.8 The Interaction ... of the Proteosome in the Regulation of Transcription 47 1.5.6 The Role of Ubiquitin and the Proteosome System Acting in Unison in Transcriptional Regulation 52 1.5.7 Common Components of the...
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Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 3
... as the link between the methylation of histone H3 residues lysine 34 and lysine 79 (H3K34 and H3K79) and the ubiquitination of histone H2B, abrogating the methylation of H3 while leaving the ubiquitinated ... 2005) 1 .3. 4 E4 Ubiquitin Ligases in the Elongation of Polyubiquitin Chains While the E3 ubiquitin ligases mediate the initial ubiquitination of the substrate, a new class of ubiquitin ligases has ... isoleucine 44 in ubiquitin is the binding site of these ubiquitin binding domains (UBDs) despite the different structural folds in each UBD resulting in minor variations with their exact interaction...
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Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... coronal section and scheme of the coronal section at E14.5 in (F) (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline Surprisingly, the ... binding is reduced, indicating that HSF4 facilitates HSF1 binding via chromatin remodelling Heat shock genes are not HSF4 targets, but HSF4 regulates a set of nonclassical heat shock genes in ... basis of incorrect pairing of sister chromatids and of the lack of integrity of the synaptonemal complex in Hsf2) ⁄ ) spermatocytes is a pending question [62] Role of HSF1 in the quality control of...
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Báo cáo sinh học: " A DNA vaccine against tuberculosis based on the 65 kDa heat-shock protein differentially activates human macrophages and dendritic cells" pot
... DNA- HSP65 Activation of the innate immune response mediated by DNA- HSP65 (A) Expression of costimulatory molecules and HLA-DR on the surface of macrophages (Mφ) and DC stimulated with DNA vaccine ... monocyte-derived macrophages and DCs Figure Phenotypic characterization of monocyte-derived macrophages and DCs (A) Expression of markers CD11b (Mac1), CD86 and HLA-DR on the surface of macrophages, and (B) ... TNF- To evaluate whether the activation induced by DNAHSP65 could increase the microbicidal capacity of macrophages and DCs against M tuberculosis, these cells were stimulated with DNA vaccine or...
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Immunomodulatory roles of heat shock proteins
... in the absence of OVA (No), or in the presence of 50 µg/mL OVA (ova), 50 µg/mL of OVA plus 5-200 µg/mL of respective heat shock proteins (Hsp/ova), 50 µg/mL of OVA plus 100 µg/mL of lactorferrin ... absence of OVA (No), or in the presence of 50 µg/mL OVA (ova), 50 µg/mL of OVA plus 5-200 µg/mL of respective heat shock proteins and 20 µg/mL PMB(Hsp/ova) , 50 µg/mL of OVA and 100 µg/mL of lactorferrin ... absence of HSP or in the presence of a control protein, lactoferrin The competence of the heat shock proteins (HSPs) to promote antigen cross-presentation was unaffected in the presence of polymyxin...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... Fig ATP-binding domain of HSP70 is essential for the inhibition of H2O2-induced activation of caspases-9 and -3 and apoptosis (A) The effects of HSP70 and its deletion mutant proteins on the ... activation Such a mechanism is independent of the interaction of HSP70 with Smac but requires the ATP-binding domain of the protein However, it ATP-binding domain of HSP70 inhibits Smac release remains ... compilation ª 2009 FEBS B Jiang et al The ATP-binding domain of HSP70 is important for the interaction of HSP70 with apoptosis signalregulating kinase (ASK1) and the inhibition of ASK1-induced apoptosis...
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Báo cáo khoa học: Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion pot
... vertebrates In conclusion, there is a single, large, evolutionarily conserved protrusion on the surface of the catalytic domain of PCSK9 The lack of other residue conservation on the PCSK9 surface ... of the mutants S15 3A -PCSK9, Q19 0A -PCSK9, R19 4A -PCSK9, D20 4A -PCSK9, K22 2A -PCSK9, R23 7A -PCSK9, D23 8A -PCSK9, D37 4A -PCSK9, C37 5A -PCSK9, S37 6A -PCSK9, T37 7A -PCSK9, C37 8A -PCSK9 and F37 9A -PCSK9 was determined ... using an antibody against the prodomain of PCSK9 The prodomains of R19 4A -PCSK9 and D20 4A -PCSK9 migrated normally (Fig 6) Thus, the two mutants were autocatalytically cleaved in a normal fashion...
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Report on the Regulation of Reproductive Cell Donation in the European Union potx
... out the findings on the principles of confidentiality, anonymity and non-remuneration in the donation of reproductive cells, as well as donor compensation, consent for egg cell donations and the ... donor offers the cells exclusively for the use of the recipient specified in the declaration of donation; c) the declaration of donation includes – beyond the provisions set forth in Subsection ... only prior to the first harvesting of reproductive cells, if the donations of reproductive cells are made repeatedly, on an ongoing basis The ongoing nature of the donations does not exempt the...
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Báo cáo y học: "Early Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response" ppt
... is in accordance with the highly increased cytokine and chemokine secretion induced by poly(I:C) and emphasizes the strong proinflammatory impact of the TLR3 ligand poly(I:C) for SAEC Regulation ... expression of other TLRs and proteins involved in TLR signaling in SAEC In addition, we demonstrate that the expression of TLRs and their signaling proteins in SAEC is strongly regulated by type-1 and ... release of inflammatory mediators The family of Toll-like receptors (TLR) plays a key role in pathogen recognition and induction and regulation of the innate and adaptive immune response Airway epithelial...
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báo cáo khoa học: " The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro" ppsx
... explain the missing regeneration potential of BONJs In contrast, the non-nitrogen-containing bisphosphonate clodronate did not have any significant impact on osteoblasts cyclin D1 gene expression ... Effect of bisphosphonates on collagen gene expression The collagen gene expression was stimulated to the most extent by ibandronate, reaching a maximum of 400% at day 10 compared to the non-stimulated ... period of 14 days Therefore, the genes of cyclin D1 and collagen were quantified by Real Time RT-PCR The nitrogen-containing bisphosphonates zoledronate and ibandronate were compared to the non-nitrogen-containing...
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Investigations on the immunopathology of enterovirus 71 1
... of EV 71 strains 18 4 CHAPTER CONCLUSION AND FUTURE WORK 19 2 7 .1 ROLE OF INTERLEUKIN-6 IN THE IMMUNOPATHOGENESIS OF EV 71 INFECTION 19 2 7.2 ROLE OF DC IN EV 71 INFECTION ... Distribution of EV 71 isolates identified globally from 19 70 to 2000 16 Figure 1. 4 Distribution of inflammation in brain sections of EV 71 patients 23 Figure 1. 5 The postulated pathology of EV 71- associated ... C2 C1 C1, C2 C1, C2 C1, C2 C1 C1 C1 C1 Norway Austria 2007 C1, C4, C5 Australia UK 2006 B5, C1 Vietnam Netherlands 2005 C1 C1 C1 C1,C2 C1 C1 C1, C2 C4 Modified from Solomon et al., 2 010 and Huang...
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Investigations on the immunopathology of enterovirus 71 3
... percentage composition per spleen The dotted line indicates the highest amount or percentage of cells observed for the two fatal strains (B) Specific anti-EV71 IgM and IgG titers in sera of infected ... CHAPTER INVESTIGATIONS ON EV71 VIRULENT DETERMINANTS B Figure 6.5 Adaptive immune response in EV71-infected AG129 mice (A) Two-week-old mice were infected ... (n=5) were euthanized and their spleens were harvested Total splenocytes were counted or stained with monoclonal antibodies specific for CD4, CD9, CD19, CD69, and CD 138 markers and analysed by...
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Investigations on the immunopathology of enterovirus 71 2
... well as the effects of the systemic inflammatory response on the vascular endothelium The key to further decipher the exact mechanisms for PE in EV71 encephalitis relies on the development of more ... observed (Shieh et al, 20 01; Yang et al, 20 09) 22 CHAPTER LITERATURE REVIEW Figure 1.4 Distribution of inflammation in brain sections of EV71 patients (A) Whole brain coronal sections of cerebral hemispheres ... severe EV71 disease Further investigations into the mechanisms underlying the role of host genetic polymorphisms in the context of EV71 infection could provide important insights into the pathogenesis...
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