Characterisation of toll like receptor 8 as a new innate immune receptor for mycobacterium tuberculosis

... CpG$DNA$ Bacteria$and$mycobacteria$ ' Fungus' Zymosan$ Saccharomyces0cerevisiae$ Phospholipomannan$ Candida0albicans$ Mannan$ Candida0albicans$ Glucuronoxylomannan$ Cryptococcus0neoformans$ ' Parasites' ... Prof!Ng!Mah!Lee!and!Yap!Han !for! electron!microscopy!work;!!Prof!Mike!Kemeny! and!Christopher!Yang! !for! cloning!the!TLR8.2 !receptor; !and !A/ Prof!Lu!Jinhua!and! Jason!Goh !for! the!TLR8!WT!plasmid!and!techniques !for! the!dual!luciferase!assay.!! Life!in!the!laboratory!would!not!have!been!so!enjoyable!without!the!company !of! ... defence! in! phagocytes,!are! vulnerable!to! mycobacterial!diseases! (Casanova! and! Abel,! 2002).! Mutations! in! natural! resistance! associated! macrophage! protein! 1! (Nramp1)! have! been! shown!...

Báo cáo hóa học: " Prevention of hyperglycemia-induced myocardial apoptosis by gene silencing of Toll-like receptor-4" potx

... Suppression of TLR4 and prevention of apoptosis by gene silencing of TLR4 (A) Suppression of TLR4 expression in the heart of STZ mice treated with TLR4 siRNA Diabetes was induced by STZ injection ... in myocardial tissue by gene silencing of TLR4 Accumulating evidence suggests that activation of the TLR4 pathway is associated with myocardial apoptosis [12] We explored whether knockdown of ... gene- specific therapeutics Am J Transplant 2004, 4:1227-1236 doi:10.1186/1479-5876-8-133 Cite this article as: Zhang et al.: Prevention of hyperglycemia-induced myocardial apoptosis by gene silencing...

Cyclic stretch enhances the expression of Toll-like Receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-B pathway doc

... siRNA inhibited the induction of TLR4 protein by cyclic stretch The NF-B binding activity and TLR4 promoter activity induced by cyclic stretch were attenuated by p38 inhibitor, indicating p38 MAP ... because the specific and potent inhibitors of an upstream p38 kinase, SB203580 inhibited the induction of TLR4 protein This signaling pathway of p38 was further confirmed by the finding that p38 ... al.: Cyclic stretch enhances the expression of Toll-like Receptor gene in cultured cardiomyocytes via p38 MAP kinase and NF-B pathway Journal of Biomedical Science 2010 17:15 • No space constraints...

Báo cáo y học: "SPLUNC1 regulation in airway epithelial cells: role of toll-like receptor 2 signaling" ppsx

... TLR2 signaling to induce inflammatory cytokine responses [39,40] These additional strains of bacteria will be included in our future studies Second, the in vivo role of airway epithelial TLR2 ... surfactant proteins A and D, mainly produced by type II alveolar epithelial cells and Clara cells, are also abundant in airway lining fluid They play a pivotal role in host defense against various ... staining of the membrane showed one protein at about 25 kD (pink, black arrow) Right panel - Western blot of SPLUNC1 using the Odyssey Imaging System verified that the 25 kD protein band shown in...

Báo cáo y học: " Expression of Toll-like Receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis" ppsx

... events bone marrow TLR9-FITC Figure of TLR9 in leukocytes from bone marrow, peripheral blood and nasal lavage fluid Expression Expression of TLR9 in leukocytes from bone marrow, peripheral blood and ... plots of intracellular staining of TLR9 in neutrophils, eosinophils, basophils, monocytes, lymphocytes and immature granulocytes Expression of TLR9 in leukocytes was analyzed by flow cytometry using ... http://respiratory-research.com/content/8/1/17 A B C Figure Expression of TLR9 in leukocytes during allergic rhinitis Expression of TLR9 in leukocytes during allergic rhinitis Intracellular expression of TLR9,...

Báo cáo y học: "Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures" ppsx

... Blockade of Toll-like receptor prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures Arthritis Research & Therapy 20 11 13:R33 Page of Submit your next manuscript ... http:/ /arthritis- research.com/content/13/1/R33 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 rheumatoid arthritis synovial fibroblasts stimulated by toll-like receptor ligands J Immunol 20 04, 1 72: 125 6- 126 5 ... blocking therapy Inhibition of spontaneous pro-inflammatory cytokine production by OPN301 from RA synovial explants in the absence of a specific TLR2 agonist suggests expression of endogenous...

Báo cáo y học: " Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease" pdf

... Respiratory Research 20 06, 7:64 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 Mediterranean population Bull Eur Physiopathol Respir 1986, 22 :21 7 -22 4 Hirschfeld M, Ma Y, Weis JH, Vogel ... 20 04, 363:731-733 Agusti AG: Systemic effects of chronic obstructive pulmonary disease Novartis Found Symp 20 01, 23 4 :24 2 -24 9 Wick G, Knoflach M, Xu Q: Autoimmune and inflammatory mechanisms in ... meta-analysis Thorax 20 04, 59:574-580 Sin DD, Man SF: Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation...

Báo cáo y học: "Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts" docx

... arthritis -associated autoantigen hnRNP-A2 (RA 33) is a major stimulator Zhu et al Arthritis Research & Therapy 2011, 13: R1 03 http://arthritis-research.com/content/ 13/ 3/R1 03 35 36 37 38 39 Page 15 of ... of arthritis Zhu et al Arthritis Research & Therapy 2011, 13: R1 03 http://arthritis-research.com/content/ 13/ 3/R1 03 Page 11 of 15 Figure Activation of FLSs via TLR3 induction stimulated by pristane-primed, ... MMP 13 expression only displayed a tendency to decrease (Figure 4B) Besides downregulation of TLR3 by RNAi, TLR3 antibody was used to block the TLR3 signaling pathway in rat FLSs With TLR3 antibody...

Báo cáo sinh học: "Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma" doc

... Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, Kitamura T, Kodama T, Fukayama M, Aburatani H: Identification of Toll-like receptor as a potential therapeutic target in clear cell renal cell carcinoma ... polyethyleneiminederived nanoparticles as a gene therapy delivery system for renal cell carcinoma Journal of Translational Medicine 2011 9:46 Submit your next manuscript to BioMed Central and take full advantage of: ... murine macrophage cell line, Ana-1, and a human umbilical vein endothelial cell line (HUVEC) respectively As a result, the toxicity of PCFC-g-PEI and FA-PEAs on Ana-1 and HUVEC cells was homoplastic...

báo cáo hóa học:" Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma" pot

Báo cáo y học: "Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease" ppsx

... 5'-AGC CGG AAG GTT ATT GTG GTA GT-3' mTLR4 lower 5'-TGC CGT TTC TTG TTC TTC CTC T- 3' mTLR6 upper 5'-ATA CCA CCG TTC TCC ATT T- 3' mTLR6 lower 5'-GAC GTG CTC TAT CAT CAG TG-3' FACS sorting, by using ... inflamed joint activated and memory T cells can pass endothelial barriers TLR ligands can activate T cells independent of antigenic specificity release of inflammatory cytokines T/ TE T/ TE T/ TE ... CTLs to proliferate and to secrete IFN-γ via TLR -2 adds another facet to the functional potential of T effector cells The fact that the same stimulatory signal leads neither to the release of...

Báo cáo y học: "Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain"

... (5’-GGCGUGUCUCUCU UACGAC-3”) SiRNAs targeting the cDNA sequence of rat TLR4 (GenBank accession NM_019178) were: 5’-CUACCAACAGAGAGGAUAU-3” (siRNA1 ), 5’-GUCUCAGAUAUCUAGAUCU-3’ (siRNA2 ), 5’-GAGCCGGAAAGUUAUUGUG-3’ ... tissues was significantly lower in the CCI group during the course of 255 TLR4 -siRNA treatment, indicating that intrathecal administration of TLR4 -siRNA significantly attenuated TLR4 induction in the ... CCI rats (Figure 3) Figure Inhibition of TLR4 signaling upon TLR4 -siRNA in CCI rats Either saline or 10μg of selected siRNA was administered intrathecally once daily for days as described in Materials...

báo cáo hóa học: " Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia" pdf

... used in the study: caspase-3: 5'gggcctgaaataccaagtca-3' and 5'-aaatgaccccttcatcacca-3'; Dsip1: 5'-ggtggccctagacaacaaga-3' and 5'-tcaagcagctcacgaatctg-3'; CIDE-B: 5' ctggaactcagctcctccac-3' and ... Bcl2-like 14 (apoptosis facilitator) BH3 interacting domain death agonist BCL2/adenovirus E1B-interacting protein Baculoviral IAP repeat-containing BCL2/adenovirus E1B-interacting protein Apoptosis ... protein Apoptosis inhibitor TSC 22 domain family Cell-death inducing DNA fragmentation factor CASP2 and RIPK1 adaptor domain containing protein Fas-associated death domain Fas apoptotic inhibitory...

Báo cáo y học: "Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus" pps

... removal of cellular debris by phagocytes Transient appearance of low affinity anti-single-stranded or dsDNA antibodies, preferentially of IgM and < /b> IgG3 isotypes, will probably accompany any systemic ... secondary to cellular activation [116] Interestingly, medications that can cause drug-induced lupus (e.g hydralazine and < /b> procainamide) are capable of blocking methyltransferase activity [117], and < /b> ... autoreactive < /b> B cells < /b> and < /b> plasmacytoid < /b> dendritic < /b> cells < /b> with inhibitory DNA sequences Halpern and < /b> Pisetsky made the original observation that certain poly-G ODNs containing the nuclease-resistant...

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Báo cáo y học: " Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in miceg" pdf

... saturated fat diet -induced insulin resistance was blunted in mice that lacked functional TLR4 It is likely that saturated fat and trans fat induce Page of inflammation and insulin resistance by ... protection against obesity and insulin resistance induced by a diet high in trans fat in mice Journal of Inflammation 2011 8:2 Submit your next manuscript to BioMed Central and take full advantage of: ... markers in macrophages, adipocytes, and liver leading to insulin resistance Insulin resistance is a main pathological abnormality associated with metabolic syndrome, obesity, and type-2 diabetes...

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