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Association analysis of genetic variation of estrogen related candidate genes in breast and endometrial cancers

Association analysis of genetic variation of estrogen related candidate genes in breast and endometrial cancers

Association analysis of genetic variation of estrogen related candidate genes in breast and endometrial cancers

... DEPARTMENT OF EPIDEMIOLOGY AND PUBLIC HEALTH YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNVERISTIY OF SINGAPORE Association Analysis of Genetic Variation of Estrogen Related Candidate Genes in Breast and ... further explore the association between genetic variants in ESR2 and breast cancer risk 7.5 Candidate gene based genetic association study Candidate genes are chosen in genetic association studies ... explore the association between genetic variants in ER cofactor and breast and endometrial cancer 7.5.3 Estrogen metabolism enzymes and ER cofactor genes are drug targets for breast and endometrial...
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báo cáo khoa học:

báo cáo khoa học: "Gene family structure, expression and functional analysis of HD-Zip III genes in angiosperm and gymnosperm forest trees" pps

... silencing by microRNAs is highly conserved in plants and specifically targets all of the HD-Zip III genes through the binding of mir165/166 [19] Functional analyses of HD-Zip III genes in herbaceous ... redundancy The aim of this study was to develop insights into the role of HD-Zip III genes in secondary xylem formation in forest trees We examined the HDZip III gene family in two unrelated tree ... neofunctionalisation or subfunctionalisation within the angiosperms Transcription profiles identify HD-Zip III putatively involved in vascular development Delineating the potential role of HD-Zip...
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báo cáo khoa học:

báo cáo khoa học: " Identification and expression analysis of WRKY transcription factor genes in canola (Brassica napus L.) in response to fungal pathogens and hormone treatments" ppt

... BnWRKY65 BnWRKY35 BnWRKY27 BnWRKY22 BnWRKY29 BnWRKY21 BnWRKY39 BnWRKY74 BnWRKY15 BnWRKY7 BnWRKY17 BnWRKY11 BnWRKY18 BnWRKY40 BnWRKY72 BnWRKY36 BnWRKY42 BnWRKY6 BnWRKY31 BnWRKY1N BnWRKY20N BnWRKY4N ... BnWRKY24 BnWRKY56 BnWRKY75 BnWRKY45 BnWRKY8 BnWRKY28 BnWRKY50 BnWRKY51 BnWRKY10 BnWRKY4C BnWRKY3C BnWRKY25C BnWRKY44C BnWRKY20C BnWRKY33C BnWRKY2C BnWRKY26C BnWRKY34C BnWRKY32C BnWRKY1C BnWRKY69 ... Figure Expression analyses of BnWRKY genes in response to fungal challenge Expression analyses of BnWRKY genes in response to fungal challenge Changes in BnWRKY transcript abundance in response to...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 1

Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 1

... 3 .1 Mia1p in assembly and maintenance of persisent iMTOCs at nuclear envelope 44 3 .1. 1 Lack of microtubule binding protein Mia1p results in fewer interphase Microtubules 44 3 .1. 1 .1 Mia1p is a microtubule ... cytoskeleton 18 18 1. 2.4 .1. 1 Architecture and dynamics of interphase microtubule cytoskeleton 18 1. 2.4 .1. 2 Functions of interphase microtubule cytoskeleton 19 1. 2.4 .1. 2 .1 Maintaining cell morphology 19 1. 2.4 .1. 2.2 ... between Mia1p and Alp14p 10 9 4.5 .1 Mia1p interacts with Alp14p but not Dis1p 10 9 4.5.2 Different aspect of Mia1p and Alp14p functions in microtubule x attachment to the NE 11 0 4.5.3 Lack of Mia1p and...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 2

Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 2

... center and plus-ends facing toward the cell tips Model of maintaining ordered microtubules (from Sawin and Tran, 20 06) is shown in the following cartoon 16 Model of interphase microtubules bundling ... critical role in maintaining cell morphology by binding to the plus ends of growing interphase microtubules in a Tip1p and Tea2p-dependent manner (Chang and Peter, 20 03) When the growing microtubules ... studies in this system identified a partner of D -TACC protein, another centrosomal protein -Minispindles (Msps), making a breakthrough in understanding normal function of TACC protein (Lee et al., 20 01)...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 3

Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 3

... 40μl TE buffer containing RNAse and incubated at 37 oC for 20min DNA was stored at -20oC 2 .3 Construction of knock out mutants and epitope tagging of genes 2 .3. 1 Construction of knock out mutants ... taxol-stabilized bovine brain 3X microtubules (50μg/ml) in the same buffer, followed by washing and immunoblotting withTAT1 anti-tubulin antibodies 2.2.5 Extraction of S .pombe genomic DNA 5ml S pombe cells ... dissolved in PBS and resuspended in 140μl of 1.2M sorbitol disolved in PBS 60μl of protoplasting buffer (50mg/ml Lysing enzyme, 30 mg/ml Zymolase, 1.2 M sorbitol in PBS) was added to the samples and incubated...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 4

Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 4

... kinetochore in metaphase (~1% of cells) and to the spindle midzone during anaphase (~5% of cells) in control cells Ark1p-GFP defined the spindle midzone in 43 % of Mia1p- overexpressing cells, and ... panel) and cells overexpressing Mia1p (right panel) coexpressing the NE marker protein, Uch2p-GFP, and the SPB protein, Sad1p-DSRed 84 3.2.3 Spindles in Mia1p- overexpressing cells are bipolar and ... 3.1.1.1: Microtubule- associated protein Mia1p binds microtubules and is a component of S pombe MTOCs (A) Shown is the maximum projection of the z-stack obtained by epifluorescence imaging of interphase...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 5

Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 5

... interphase microtubule arrays 4 .5. 3 Lack of Mia1p and Alp14p result in failure of iMTOCs establishment Another striking aspect of Mia1p function has been illuminated by lack of large interphase MTOCs in ... that S pombe cells overexpressing the TACC- related protein, Mia1p, were capable of organizing spindle-pole like structures While formation of intranuclear microtubule bundles in interphase S pombe ... understand how detachment of minus ends of microtubules resulted in the absence of detectable iMTOC structures in mia1Δ cells I proved the role of microtubules in establishing the iMTOCs in two...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 6

Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 6

... spindle assembly checkpoint in fission yeast Nat Cell Biol 5, 764 - 766 ; author reply 766 68 Sato, M., and Toda, T (2007) Alp7 /TACC is a crucial target in Ran-GTPasedependent spindle formation in ... Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development Mech Dev 97, 13- 26 66 Samejima, I., Lourenco, P.C., Snaith, H.A., and Sawin, K.E ... 1 461 -1479 22 Drummond, D.R., and Cross, R.A (2000) Dynamics of interphase microtubules in Schizosaccharomyces pombe Curr Biol 10, 766 -775 23 Drummond, D.R., and Hagan, I.M (1998) Mutations in...
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A contrastive analysis of grammatical and semantic features of words and idioms related to hearing in english and vietnamese

A contrastive analysis of grammatical and semantic features of words and idioms related to hearing in english and vietnamese

... in So far there has been no contrastive analysis of grammatical English and Vietnamese in terms of grammatical features? and semantic features of words and idioms related to hearing in What are ... …etc to grammatical features and semantic features of verbs and idioms in fulfill the meaning Or to denote the meaning of hearing without the English and Vietnamese And after analysing we can draw ... similarities and differences between WIRHs in English and Vietnamese For this reason, a contrastive analysis of English and Vietnamese in terms of semantic features? grammatical and semantic features...
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An analysis of errors related to the uses of english prepositions at, on, in produced by elementary level students at foreign languages & informatics center vinh city

An analysis of errors related to the uses of english prepositions at, on, in produced by elementary level students at foreign languages & informatics center vinh city

... carried out at Language and Informatics Center- Vinh City 1.3 OBJECTIVES The objectives of the thesis are: - Identifying the errors in using the prepositions of place and time: AT, ON, IN by Vietnamese ... at the top of the page / of + N 24 at the end of the road at the corner of the street in the corner of the room at the front / at the back of a building, hall, group of people In the front / the ... that errors are 12 originated in the learners’ disposition to transfer forms and meanings, and the distribution of forms and meanings of their native language and culture to the foreign language...
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An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology potx

An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology potx

... production of cytokines and serotonin involved in anorexia/cachexia and emesis by peripheral blood mononuclear cells of cancer patients Eur J Cancer 1997, 33(4):602-607 Nalbandian G, Kovats S: Understanding ... calcitonin, and environmental factors like dietary calcium intake and physical activity In addition to these factors, estrogen and serotonin play an important role in the development and maintenance of ... 1(5):296-302 Sanders-Bush E, Mayer S: 5-Hydroxytryptamine (Serotonin) receptor agonists and antagonists In Goodman and Gilman's the Pharmacological Basis of Therapeutics 9th edition Edited by: Hardman JG,...
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Báo cáo hóa học:

Báo cáo hóa học: " Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer" pot

... question of detecting therapy-related changes in the mass profiles registered for blood samples collected from breast cancer patients SELDI-ToF analysis of the plasma proteome of breast cancer patients ... Pietrowska et al., Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with earlystage breast cancer Journal of Translational Medicine 2010, 8:66 ... possibility of applying mass spectrometry-based blood proteome pattern analysis in diagnostics of breast cancer These works identified serum (or plasma) proteome patterns specific for patients with breast...
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Báo cáo sinh học:

Báo cáo sinh học: "Detailed genetic analysis of hemagglutinin-neuraminidase glycoprotein gene in human parainfluenza virus type 1 isolates from patients with acute respiratory infection between 2002 and 2009 in Yamagata prefecture, Japa" docx

... Detailed genetic analysis of hemagglutininneuraminidase glycoprotein gene in human parainfluenza virus type isolates from patients with acute respiratory infection between 2002 and 2009 in Yamagata prefecture, ... HPIVi /Yamagata /2009/ 25 81 HPIVi /Yamagata /2009/ 2009 HPIVi /Yamagata /2009/ 2075 HPIVi /Yamagata /2009/ 2055 HPIVi /Yamagata /2009 /12 51 HPIVi /Yamagata /2009 /14 41 HPIVi /Yamagata /2009 /17 86 HPIVi /Yamagata /2009/ 2 019 ... Y03 /16 44 Y03 /17 64 Y03 /13 68 Y03 /15 21 Y03 /15 23 Y03/ 210 1 Y04 /17 73 Y04/759 Y03 /13 23, Y03/2066, Y03 /16 65 Y03 /14 46 Y03/2030 Y05 /11 09, and others ( 21) Y05 /17 89 84 Y05 /13 46 97 Y02 /14 33,Y02 /15 65 Y03 /11 22...
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