... failed to increase BIM expression, the combination of PD0325901 and rapa-mycin was more effective than PD0325901 alone, and death arising from the combination therapy was atleast partially BIM- dependent ... oncoprotein [56]. The mutant BCR–ABL tyro-sine kinase activates several signalling pathways, includ-ing the ERK1 ⁄ 2 pathway, the PKB pathway and theJanus kinase ⁄ signal transducer and activator of ... role of BIM as a mediator of tumour cell death in response to novel oncogene-targeted therapeutics. AbbreviationsAML, acute myeloid leukaemia; b-TrCP, b-transducin repeat containing protein; BAD,...