... developsAbbreviationsapoE, apolipoprotein E; apoE) ⁄ ), apoE deficient; apoE3knock -in mice, mice containing a targeted replacement of the mouse apoE gene for thehuman apoE3 gene; FFA, free fatty acid; ... NAFLD in these mice. Rather, our results have established thatapoE deficiency has a protective effect against hepatictriglyceride accumulation, despite the apparent increase in plasma cholesterol ... performed. We found that deficiency in apoE has a protective effect on diet-induced hepatic triglyceride accumulation, and theapoE-mediated development of diet-induced NAFLD in mice is independent...