... R166
Research
Egr1 regulates the coordinated expression of numerous EGF
receptor target genes as identified by ChIP-on-chip
Shilpi Arora
*
, Yipeng Wang
*†
, Zhenyu Jia
*
, Saynur Vardar-Sengul
*‡
,
Ayla ... effector of the Map kinase/ERK
pathway, mediator of a variety of growth factor receptors such
as the epidermal growth factor receptor (EGFR) [17]....
...
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Corresponding address: Andrew E. Czeizel Foundation for the Community Control of Hereditary Diseases, 1148 Budapest, ... evaluated, the
period of study (only at birth or in early neonatal period
or prenatal or the whole infant period are included), the
completeness of ascertainment, the dia...
... certainty that the
effect is a real one. Secondly, it could be the case that the trangene molecules bound only weakly to the
sperm cells, such that only direct delivery (by ICSI) permitted the ... transgenes, derived from the same (syngenic) laboratory animal
strain as the target animal, contain homology blocks that are genetically identical (or virtually identical)
to...
... guanidinium carbon of agmatine. Thus, the
disruption of this hydrogen bond is the likely cause of the
greately decreased catalytic efficiency of the D153N variant.
Keywords: agmatinase; Asp153; site-directed ... DISCUSSION
By site-directed mutagenesis, a D153N mutant form of
E. coli agmatinase was obtained. The mutant enzyme
retained about 5% of wild-type activity and it...
... Stereochemistry of the isoprenylation of
tryptophan catalyzed by 4-(g,g-dimethylallyl) tryptophan synthase
from Claviceps, the first pathway-specific enzyme in ergot alkaloid
biosynthesis. J. Am. ... H
A
-hydrogen of IPP. In
both cases, scrambling of the label takes place within the IPP
pool and the error is then transcribed into the DMAPP pool by
the normal action of...
... Escherichia coli
as fusion proteins with glutathione S-transferase using the
pGEX-3X plasmid, and purified as described previously [4].
The purity of both apoE3 and apoE4 as assessed by SDS/
PAGE was estimated ... between the density
and molar mass of the fractionated emulsion particles,
we assumed a spherical monolayer of Myr
2
Gro-PCho
surrounding a core of TO, suppor...
... technology has been,
theoretically, to increase the safety and com-
pleteness of surgery in addition to increasing the
confidence of the surgeon. This accounts for the
increasing numbers of health centres ... tissue
contraction. Obviously, another indication for
revision surgery is recurrent polyp disease that can-
not be managed medically or in the office.
Technical State of...
... diseases of aging for which
there is little, if any, effective treatment. It accounts for more
mobility disability in the elderly than any other disease.
Symptomatic knee OA affects roughly 12% of ... currently
ongoing. The effects of patellar braces on patellar
malalignment are also unclear, but braces may push the
patella into the trochlear groove [67], thereby increasing the...
... consequence of the activation of many cell populations
and, ultimately, of the upregulation of proinflammatory cyto-
kines [19,20]. By whichever means they themselves become
activated, they induce ... characteristics of the
disease
A new look at assessing active disease
Clinical fact 1
Composite indices are the best depicters of
disease activity. The degree of diseas...
... sensitivity of the test for antibodies in RA was
increased from 24% to 88% when the intact CII molecule
was replaced by CB10 and, notably, this was not at the
expense of specificity, which was 94% ... con-
trols. The use of these sera for the present study was
approved by the Standing Committee on Ethics in
Research involving Humans of Monash University.
Preparation o...