Báo cáo y học: " Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)" docx
Báo cáo y học: " Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)" docx
... and protein C levels. Since the patients with severe protein C deficiency could poten tially have thegreatest increases in protein C activity given their verylow starting points, one logically ... 13:R83.doi:10.1186/cc9382Cite this article as: Shorr et al.: Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated). Critical ... 14:R229http://ccforum.com/content/14/6/R229Page 12 of 14RESEARCH Open Access Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)Andrew F Shorr1*,...
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Báo cáo y học: "Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept" pot
... during recent years, remains a subject of controversyregarding technical details [11]. Also, radiography isimpractical in early stages of drug development, i.e. forproof of drug efficacy in ... trials are corroborated by changing levels of circulating COMP. Rheumatoid arthritis patients commencingtreatment with infliximab (N= 32) or etanercept (N = 17) weremonitored in accordance with a ... aMedian(range). ACR20 = 20% improvement according to the AmericanCollege of Rheumatology criteria; CRP = C- reactive protein; COMP =cartilage oligomeric matrix protein; DAS = disease activity score; HAQ...
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Báo cáo y học: "bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction" pdf
... administration resulted in a significantenhancement in leucocyte–EC interaction, as indicated bytransiently increased number of leucocytes firmly attaching tothe microvascular endothelium of arterioles ... antifibrinolysis. LPS, lipopolysaccharide; M,activated monocyte; SMC, smooth muscle cell; TF, tissue factor; TM,thrombomodulin.ECSMCMPAIAntifibrinolysis CoagulationLPS,LPS,cytokines cytokines ... binding, which in turn facilitatesrolling. Selectins allow leucocytes to roll in the direction of flow into the proximity of activating signals exhibited by ECs.The second step involves receptors...
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Báo cáo y học: "Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock - does the dose matter" pps
... with β-lactams) and/or of drug-drug pharmacokinetic interactions, which may becomeespecially relevant for those antimicrobials that may inhibit(erythromycin or clarithromycin) cytochrome P450-mediateddrug ... Adapted with permission from Pea and coworkers [64].Specific pathophysiological andpharmacokinetic/pharmacodynamiccharacteristics in critically ill patients with severe sepsis/ septic shockRecent ... outcome in critically ill patients with severe infections, and indicate thatcontinuous infusion may be the best approach in terms of maximizing efficacy with time-dependent antimicrobials.Indeed,...
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Báo cáo y học: "Earthquake-related versus non-earthquake-related injuries in spinal injury patients: differentiation with multidetector computed tomography" pptx
... spinal injuriesrarely occur as a result of crush injury [8,17]. In ourearthquake-exposed cohort, however, crush injury w asthe leading cause of spinal injury. As spinal injuriesoccur most commonly ... ourseries, the incidence of neurologic de ficit was muchhigher in both cohorts. The incidence of neurologicaldeficits increased significantly between AO types, whichis similar to the finding of Magerl ... trau-matic spinal injuries investigated by Magerl et al.[10],type A fracture occurred most commonly (66.1%),whereas types C and B occurred in 19.4% and 14.5% of patients, respectively. In our investigation,...
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Báo cáo y học: "Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients"
... citation purposes)ical Care Medicine (ACCM) of the Society of Critical Care Medi-cine (SCCM), American Society of Health-System Pharmacists(ASHP), American College of Chest Physicians: Clinical ... American College of Chest Physicians, AmericanCollege of Emergency Physicians, Canadian Critical Care Society,European Society of Clinical Microbiology and Infectious Dis-eases, et al.: Surviving ... of Alcohol Withdrawal Delirium, Practice GuidelinesCommittee, American Society of Addiction Medicine: Manage-ment of alcohol withdrawal delirium: an evidence-based prac-tice guideline. Arch...
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Báo cáo y học: " Randomized trial of achieving healthy lifestyles in psychiatric rehabilitation: the ACHIEVE trial" doc
... physical activityand 5-minute cool down [45]. The exercise durationgradually increases each week until participants arecompleting 40 minutes of moderate intensity physicalactivity and 10 minutes ... during the trial willinform future cost s of continuing the intervention. Prac-tical considerations for intervention sustainability anddissemination are c omplex and include how cardiovas-cular ... USA.9Department of Epidemiology and Biostatistics, University of MarylandSchool of Public Health, College Park, Maryland, USA.10Department of Psychiatry, Johns Hopkins University School of Medicine,...
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Báo cáo y học: "Intensive insulin treatment improves forearm blood flow in critically ill patients: a randomized parallel design clinical trial" ppsx
... rate of insulin infusion, although norelation with the glucose concentration was found. Based onour findings, it may be concluded that a certain increase in flowmay be reached with insulin doses, ... glu-cose concentration and forearm flow, which cannot be defini-tively explained. In another study the influence of intraarterialinsulin infusion on protein synthesis in skeletal muscles in ... in the surgical intensive careunit [3]. In another study of medical critically ill patients, mor-bidity but not mortality was reduced by intensive insulin treat-ment [4].APACHE: Acute Physiology...
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Báo cáo y học: "Clinical review: Strict or loose glycemic control in critically ill patients - implementing best available evidence from randomized controlled trials" ppsx
... Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society ... preventing and/or treating hyperglycemia in critically ill patients. Glycemic control aiming at normoglycemia Randomized controlled trials on strict glycemic controlTable 1 presents a summary of ... complication of SGC. Undoubtedly, with implementation of SGC the incidence of severe hypoglycemia increases. Reported incidences of severe hypoglycemia (blood glucose level <40 mg/dl) rise by fi...
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Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"
... signficant increase in urine Cu levels in patients suffering from myocar-dial infarction (MI) (15). Reunanen et al. (1996) found increased levels of serum Cu in patients with CAD (14). In contrast, ... having normal coronary arteries attending car-diology clinic at Yuzuncu Yil University Hospital. The study was approved by the local ethics committee according to the declaration of Helsinki, ... from a cohort study of eastern Finnish men, in which high levels of serum ferritin and dietary Fe intake were positively associated with the incidence of myocardial infarction. Ascherio et...
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