... circulating ghrelin is
derived from the stomach and nearly all of the remaining
one third from the small intestine [5,6]. Rat ghrelin is very
similar to human ghrelin and differs only by two amino
acids ... physiologically growth hormone
(GH) secretion independent of hypothalamic GH-releas-
ing hormone and causes weight gain and obesity by
increasing food intake and dimini...
... Normal
in the thalamus and in the in the thalamus and in the of hypersignals found
basal ganglia basal ganglia previously
T2 Hypersignals in the cortex, Hypersignals in the cortex, Hypersignals of ... predicting chances of recovery.
Ascending reticular activating system and
prognosis of brain injuries
Several brain areas involved in the prognosis of TBI or strok...
... Of these, 8,312 in human and 8,105
in mouse are single-copy genes, and the remaining are clus-
tered by Ensembl into 3,538 families in human and 3,600
families in mouse.
We paired genes within ... effectively eliminates erro-
neous detection of old duplicates as young ones and reduces
the influence of gene conversion. Consequently, the duplica-
tion rate in yeast estim...
... peptide-independent pathway and calls for further
investigation on this subject.
Enzyme activity and specificity
In the standard tricaprylin hydrolysis assay, rPFL displayed
highest activity at 29 ... number of disulphide bridges, the location of
proline and arginine residues, and hydrophobic core
interactions are generally recognized as key factors in
determining the flexibilit...
... Immunohistochemistry showed
that TIARP protein was mainly localized in hyperplastic
synovium. Among the STEAP family of proteins, STEAP4 was
highly upregulated in joints of patients with RA and especially
co-localized ... days 7 and 8, peaked in severity on day 14,
and then gradually subsided. High expression levels of TIARP mRNA and proteins were detected in splenocytes...
... effects, in
part, by inducing cancer cells to invade the perineurium,
a great deal of evidence suggests that NGF may directly
induce hypersensitivity in sensory neurons in both in vitro
and in vivo ... dichotomy seen clinically between pressure induced
pain (which occurs in both benign and malignant
tumors) and rest pain (largely a symptom of malignancy)
suggests that th...
...
upregulated in response to NTHI infection in COPD lung tissue in vivo and in vitro. The combination of NTHI-mediated
induction of proinflammatory cytokines and inhibition of TGF-β expression may influence ... expression of pseudorecep-
tor and cytokine could play a crucial role in TGF-β effec-
tor function and may be explained by the binding of TGF-
β on BAMBI....
... reflecting inflammation (ESR), endothelium injury
(sVCAM), or synovial involvement (COMP and YKL-40).
While we failed in the identification of any link, sVCAM,
COMP, and YKL-40 were found to be increased ... glycoprotein-39 (YKL-40), and carti-
lage oligomeric matrix protein (COMP) markers of
endothelial injury, progenitor mobilization, synovitis, and
synovitis, respectively wer...
... activity in stimulated T
cells and may play a critical role in the duration and
potency of the immune response [16].
In this study, a carboxy-terminal fragment of p65/RelA
that can be detected in ... and -6 could not
be the primary caspases required for apoptosis in T cells
[43].
Binding affinity assay of p65wt-tag and ΔNH
2
p65-tag to IκBα by using in vitro transl...
... assay. According to the
manufacturer, the limit of quantification (LOQ) is 0.8 μg/
ml.
PK analysis
Serum amikacin concentrations were analyzed by using
WinNonlin Pharsight Professional Software ... [34]. For aminoglycosides, peak
concentration is determined by the administered dose
and by the V
d
[30]. The V
d
of amikacin is between 0.2 and
0.3 L/kg in healthy volunteers and...