Báo cáo y học: " Recent advances in the investigation of curcuminoids" doc

... enhancedanti-inflammatory activity. The increased size of the cyclo-alkanone ring, by replacing the cyclopentanone in 27 witha cyclohexanone in 25, increased inhibitory potency.However, this ... HIV-1 integrase is the enzyme that catalyzes the integration of the double-strained DNA of HIV into the host chromosome [54].Curcumin inhibited this activity of HIV-1 integrase [54].Other classes ... potent in the lipid peroxidation assay, indicatingthat steric hindrance at the positions flanking the hydroxyl group decreased anti-oxidative activity. Chang-ing the 3'-methoxy group in curcumin...

Báo cáo y học: "Recent developments in the immunobiology of rheumatoid arthritis" potx

... humanmonocytes/macrophages in a contact-dependent manner toinduce the expression of inflammatory cytokines, includingTNFα [24,25]. A recent study further demonstrated that RAsynovial T cells induce ... anti-IL-15 therapy in RA patients [29].T helper 17 cellsThere is increasing evidence that IL-17 plays a role in the immunopathology of RA. This proinflammatory cytokine isproduced by T helper ... anti-CD20 antibody[2], and the increased interest in the role of autoantibodies in RA. In addition to producing antibodies, proinflammatorycytokines and chemokines, B cells efficiently act as antigen-presenting...

báo cáo khoa học: " Recent advances in the genetics of language impairment" docx

... differences in the sets of downstream genes that were identified. is finding demonstrates the complexity of these regulatory path-ways and the inherent difficulties of precisely defining them in the ... from the cytosol into the Golgi body [74]. Calcium is an important ion in the regulation of many neuronal processes, including working memory, synaptic plasticity and neuronal motility [75], ... members of the SLI Consortium.Competing interests The authors declare that they have no competing interests.Published: 26 January 2010References1. Pinker S: The Language Instinct: The New...

Báo cáo y học: "Recent advances in our understanding of human host responses to tuberculosis" doc

... during the past several years to be a key effector cytokine in the host response against tuberculosis. Th2 cells primarilysecrete the cytokines interleukin-4, interleukin-5, and inter-leukin-10, ... evi-dence for the importance and potential clinical utility of thiscytokine in vaccine development, or perhaps as adjunctiveimmunotherapy.CD8+T lymphocytesDuring the past 3–4 years, increasing attention ... Tc1phenotype, similar to a Th1 phenotype, is the predominanttype of CD8+cell; in addition, they are cytotoxic T cellsand probably play a significant role in true protectiveimmunity of the type...

Báo cáo y học: "Recent advances in nanoparticle formulation of oleanolic acid" docx

... mL) by film-ultrasonic* Correspondence: ytwang@umac.mo† Contributed equallyState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of ... after the freeze-drying pro-cess. The particles of the best sample achieved a meanparticle size of 236.3 nm and a much higher polydisper-sity index of 0.242 [19]. The study showed that the opti-mum ... Study on preparation of oleanolic acid liposomes. Journal of Xinjiang Medical University 2007, 30:581-583.24. Xiao Y, Song Y, Chen Z, Ping Q: Preparation of silymarin proliposome: anew way to increase...

Báo cáo khoa học: "Recent advances in the surgical care of breast cancer patients" pps

... this information has resulted in a rapidincrement of Breast Fellowship, recognizing that appro-priate training is one of the key factors in improvingquality of care. Currently, the number of ... ChemotherapyAn area of particular interest is the use of SLN biopsy in patients undergoing neoadjuvant chemotherapy, because the number of patients choosing this option isincreasing.Until recently, ... with the wireis not always possible, and the angle of access and tra-jectory depends, in part, on the radiologist’ sability.Further more, the introduction of the wire directly above the lesion...

Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"

... purposes) of portacaval shunting, thereby decreasing first passmetabolism; decrease in quantities and affinity of plasmaproteins, thereby increasing free-drug levels; increase in volume of distribution ... and lamotrigine. The triad of hypersensi-tivity includes fever, rash and internal organ involvementwith onset of symptoms within 1 to 8 weeks of exposure. The frequency of the syndrome is estimated ... [57].Recognizing early symptoms of hepatic toxicity and dis-continuing treatment are important in optimizing recov-ery. Early symptoms of hepatic toxicity include apathy,malaise, fever, diminished...

Báo cáo Y học: Expression pattern in the antennae of a newly isolated lepidopteran Gq protein a subunit cDNA potx

... be the start of the proteincoding domain. Sequence analysis of the 3¢ end cDNArevealed that there is a polyadenylation signal upstream of the poly(A).Analysis of the primary structure of M. ... FEBS 2002Recently, the a subunit of a G protein of the Gq familyhas been immunolocalized in olfactory sensilla preparations of the silkmoth Antherea pernyi [23]. Using immunocytol-ogy, the authors ... samecharacteristics, the molecular cloning of the correspondingcDNA to get the total amino-acid sequence of the protein,and the expression pattern of the corresponding mRNAas a ﬁrst step to clarify the role of...

Báo cáo y học: "Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes" ppt

... fibroblast lines. YM participated in the molecular genetic studies and analysis. EK procured the sam-ples and helped in the analysis of data. GW participated in the design of the study, analysis of data, ... earlybacterial infection in the joint. Somatic mutations in mitochondrial peptides displayed by MHCs may be recognizedas non-self, furthering the destructive immune infiltration of the RA joint. ... derived from the amino terminus of mtND1 [14]. These findings provide evi-dence that antigenic peptides of human mtND1 may be dis-played and recognized by the immune system.To test the hypothesis...

Báo cáo y học: "Psychosocial aspects in the management of arthritis pain" pot

... of leisure in maintaining or restoring psychological well-being in the presence of arthritis pain warrants furtherstudy.Psychosocial approaches to managingarthritis painSearch strategy The ... [16]compared the psychosocial functioning and coping of mothers with chronic pain (including mothers with arthritis) tomothers without pain, with regard to their ratings of parentingefficacy. There ... Acomparison of conventional pain coping skills training andpain coping skills training with a maintenance training com-ponent: A daily diary analysis of short- and long-term treat-ment effects. J Pain...

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