... exploring the route of PARP inhibition involved in renal hemodynamic during LPS-induced lung injury aggra-vated by MV. We tested the hypothesis that renal bloodflow and endothelial, functional and ... in the kidney of rats with LPS-induced lung injury aggravated byMV, is caused, in part, by activation of PARP by peroxyni-trite. We demonstrated that inhibition of PARP activationby peroxynitrite ... functional and tissue changes in the kidney of rats with lipopolysaccharide (LPS)-induced lung injury aggravated by MV, is caused, in part, by activation of PARP by peroxynitrite.Methods: Anesthetized...