Báo cáo y học: " The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells" potx

... that p 21/ waf1 and cyclin D2 are complexed together in HTLV -1 infected cells.Cell cycle analysis of cyclin D2 and p 21/ waf1 p 21/ waf1 has been previously described as an assemblyfactor for cyclin ... cdk4, cyclin E, p 21/ waf1 wildtype (WT), p 21/ waf1 mutant in the cyclin binding site (mut), p16/INK4A, and cyclin D2 were expressed and purified using affinity tag chromatography. Following purification ... http://www.retrovirology.com/content /1/ 1/6Page 8 of 17 (page number not for citation purposes)waf1 mutant in cyclin binding site (mut), p16/INK4A, cyclin E, and cyclin D2 in insect cells, and purified themusing affinity tag...

Báo cáo Y học: The role of hydrophobic active-site residues in substrate speciﬁcity and acyl transfer activity of penicillin acylase pdf

... phenylalanine was thereforemutated to Ala, Leu, Trp or Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and afﬁnity of the enzyme ... value.kcat(s )1 )Km(mM)kcat/Km(mM )1 Æs )1 )KiPAA(mM)WT 16 .2 0. 015 10 80 0.05 bF24A 1. 6 0.275 6 1. 10bF24L 36 0 .14 2 248 0 .15 bF24W 1. 5 0 .10 1 15 0.88bF2 4Y 12 0.3 51 34 1. 11 bF57A 17 0.040 425 0.23bF57L 24 0.049 490 0 .11 bF57W 1. 6 0.028 57 0 .15 bF5 7Y ... substratebinding residues bP22(CB) and bF24(CE2), respectively.Changing the acyl binding site by mutagenesis may in uence the synthetic capacities of PA in different ways. The relative afﬁnity of the...

Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps

... showed the induction of metalloproteinases by IL -17 in synoviocytes and chondrocytes [48–50]. Interestingly, the IL -17 family subtypes IL -17 F and IL -17 E also showedcartilage destructive potential in ... family members and their receptorsLigand Receptor RefsIL -17 (IL -17 A) IL -17 R (IL -17 AR) [5 ,11 ]IL -17 B IL -17 BR (IL -17 RH1/IL -17 ER) (low affinity) [7,8 ,18 ]IL -17 C ? [7]IL -17 D ? [80]IL -17 E IL -17 ER ... resulted in elevated levels of IL -1 protein in the synovium [ 41] . Intriguingly, blocking of IL -1 /β withneutralizing antibodies had no effect on the IL -17 -inducedsynovial inflammation and joint...

Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps

... The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002,39:237-246. 11 . Goldring MB: Anticytokine therapy for osteoarthritis. ExpertOpin Biol Ther 20 01, 1: 817 -829. 12 . Brandt ... 378,930.3 10 3,236.2IL-8 (n = 7) 325.62 10 8.67 211 . 81 64.35 245.04 75.69 13 4.75 37.48MCP -1 (n = 7) 62.29 15 .43 60.29 16 .17 51. 58 13 .95 41. 56 11 .65MMP -1 (n = 7) 1, 398 .1 513 .0 1, 4 31. 9 617 .6 1, 083.4 ... directly due to the inhibition of fibroblast-produced cytokines and/ or MMPs or indirectlydue to cytokine-mediated inhibition of the production of growth factors [16 ]. The majority of studies of the...

Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf

... tointerfere with the inflammatory response in SLE by adminis-tering only an induction regime of four infusions of infliximabwithin 10 weeks rather than by planning for long-term therapy.Evidence ... 66:455.60. Hayat SJ, Uppal SS: Therapeutic efficacy and safety profile of infliximab in active systemic lupus erythematosus. ModRheumatol 2007, 17 :17 4 -17 7. 61. Hayat SJ, Uppal SS, Narayanan Nampoory MR, ... perpetuation of inflammatory responses(Figure 1) . When the role of TNF and TNF inhibition in systemic lupus erythematosus (SLE)–especially the latter twoeffects–is examined, modulation of the immune (and...

Báo cáo y học: " The role of poly (ADP-ribose) polymerase in ventilator-induced lung injury" ppsx

... activation of proinflam-matory cytokines? In addition, it would be of interest toidentify the type of cells exhibiting elevated PARP activity –for instance, perhaps by double staining with leukocytemarkers. ... microscopyrevealed evidence for type I pneumocyte membrane disrup-tion and endothelial detachment, indicating structural injury. In line with the findings by Kim and colleagues, the wet/dryratio ... leukocytemarkers. In our opinion, the clinical relevance of the study islimited due to very high peak airway pressures used.Letter The role of poly (ADP-ribose) polymerase in ventilator-inducedlung injuryMichiel...

Báo cáo khoa học: The role of residues R97 and Y331 in modulating the pH optimum of an insect b-glycosidase of family 1 pdf

... which step(glycosylation or deglycosylation) of the hydrolysis of MUbglc by the mutant enzymes is rate-limiting, no hypo-thesis on the effect of R97 and Y3 31 on the rate constant of each step ... completely explain the DpKa of E187 in the Y3 31F mutant, because in the R97K and R97M mutants the same increment in the pKa of E399 did not change signiﬁcantly the pKa of E187. Thissuggests that in ... isoccurring in the mutant R97M, because there is no data on the interactions between the substrate and the arginineresidue.Finally, another aspect of the R97 and Y3 31 in uence oncatalysis that...

Báo cáo khoa học: " The role of marine salt and surfactants in the decline of Tyrrhenian coastal vegetation in Italy" ppt

... wasassessed by ascertaining the percentage of dam-aged leaves (ie leaves with yellowing) and the quantity of NaCl absorbed through the leavesshown by the increase of the Cl- ... aerosol The determination of surfactants and chlorides (the latter are useful as indicators of the pres-Original article The role of marine salt and surfactants in the decline of ... only reach 1 ppm or above in 32.5% of cases, and onlygo above 10 ppm in 2.9%. Inland, MBASconcentrations reach a maximum of 0.9ppm and only go above 0 .1 ppm in 13 .1...

Báo cáo y học: "The trauma of ongoing conflict and displacement in Chechnya: quantitative assessment of living conditions, and psychosocial and general health status among war displaced in Chechnya and Ingushetia" pptx

... health(including mental health) problems [8 -10 ]. Generallyspeaking the proximity to the event [11 -13 ], the severity of the incident [14 ], and the extent of the physical injuryincreases the risk of ... 59.7%Taking risks to find food 11 9 46.5% 12 5 44.2%Burning of houses 11 4 44.5% 11 7 41. 3%Witnessed eventsArrests 13 6 53 .1% 13 7 48.4%Maltreatment 14 4 56.2% 12 6 44.5%Killings 58 22.7% 68 24 .1% Torture ... 256 % n = 283 %Praying 13 7 53.5% 13 1 46.3%-Aggression 40 15 .6% 46 16 .3%-Talking 32 12 .5% 40 14 .1% -Keep busy 24 9.4% 46 16 .3%-Drug/alcohol use 13 5 .1% 26 9.2%- Other 10 3.9 %10 3.5%Third mentioned...

Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (steﬁn A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the totalunitary free energy of binding of cystatin A to cathepsin ... for wild -type cystatin A.EnzymeCystatin AformKd(M)kass(M )1 Æs )1 )kdiss(s )1 )Papain Wild -type 1. 8 · 10 )13 a3 .1 · 10 6a5.5 · 10 )7a [1] [1] [1] L73G 5.8 · 10 )11 b (1. 58 ± 0.02) ... cathepsin B,demonstrating a major role of the second binding loop of cystatin A in the inhibition of this enzyme. Pro74 may bedirectly involved in the interaction with cathepsin B byproviding hydrophobic...

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