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Báo cáo y học: "Nitrogen washout/washin, helium dilution and computed tomography in the assessment of end expiratory lung volume" docx

Báo cáo y học:

Báo cáo y học: "Nitrogen washout/washin, helium dilution and computed tomography in the assessment of end expiratory lung volume" docx

... dividing the difference in peak inspiratory airwaypressure and the plateau inspiratory pressure, measured dur-ing an end inspiratory pause, by the inspiratory flow preceding the occlusion. The ... of end expiratory lung volume (EELV) measured by the helium dilution technique and the computed tomography (CT) scanComparison of end expiratory lung volume (EELV) measured by the helium dilution ... between the increase of EELV and the differ-ence between the volume measured by the CT scan and the volume measured by the helium dilution technique. Indeed the EELV measured by the helium dilution...
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Báo cáo y học:

Báo cáo y học: "Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury" docx

... diminishing mortality, in patients with acute lung injury and also is likely to prevent the development of lung injury when used as the initial mode of ventilation [11-14].  erefore, the clinically ... clinically relevant questions now become whether inhaled APC can diminish the severity of lung injury when used in conjunction with low-tidal-volume ventila-tion in the presence of acute lung injury ... that the benefi cial eff ects of inhaled APC may result from reversing altera tions in coagulation and fi brinolysis, which are almost ubiquitous fi ndings in acute lung injury, or possibly from...
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Báo cáo y học:

Báo cáo y học: "Correction: Nitrogen washout/washin, helium dilution and computed tomography in the" pptx

... tomography in the assessment of end expiratory lung volume Critical Care 2008, 12:R150.CorrectionCorrection: Nitrogen washout/washin, helium dilution and computed tomography in the assessment of end ... 0.0001). (b) The Bland-Altman plot of the EELV measurement obtained increasing the FiO2 and the EELV obtained decreasing the FiO2. The x axis shows the mean of the two measurements and the difference ... measured by increasing the FiO2as a function of the EELV obtained decreasing FiO2. The EELV obtained increasing the FiO2was -56 + 1.0078 multiplied by the EELV obtained decreasing the FiO2(r2=...
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Báo cáo y học:

Báo cáo y học: " Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury model" pptx

... VTMV, in the absence of infection, inducedup-regulation of TLR4 and down-regulation of IRAK3 and IBa proteinlevels,resultinginanincreaseofpro-inflammatory cytokines levels in the lungs and in the ... levels of pro-inflammatory cytokines in patients with acute lung injury [5,31]. The ability of MV to induce inflammation may be in part explained by its known ability to modulate the induction of ... levels of those cytokines. Therefore,their study also suggests that TLRs play a role in the inflammatory response initiated by MV in healthy lungs.Our study is complementary to a study by Moriyama...
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Báo cáo y học:

Báo cáo y học: "Pro/con clinical debate: Are steroids useful in the management of patients with septic shock" ppt

... Simone†‡, Randy Wax§¶, Katherine G Craig** and Keith R Walley††*Resident, Department of Medicine, University of Toronto, Canada†Resident, Division of Thoracic Surgery, University of Toronto, ... is reasonable and appropriate.Con: steroids are not useful in the management of septic shockKatherine G Craig and Keith R Walley The debate surrounding the use of corticosteroids in septicpatients ... most of the organs have improved. He has good urineoutput and does not have any evidence of heart failure. Thereis no active bleeding and currently no signs of new orongoing infection. You wonder...
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Báo cáo y học: "Pro/con clinical debate: Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis" ppt

... hypoxicover the first 24 hours, requiring intubation and mechanicalventilation. The patient is admitted to the intensive care unit and, in the course of investigation, he has an abdominal computed ... Cohn41Professor and Chief of Intensive Care and Accident Department, University Hospital Maastricht, The Netherlands2Trauma Surgeon and Intensivist, University Hospital Maastricht, The Netherlands3Fellow ... mortality rate, 0% versus 15%), butno difference in the rate of infection of pancreatic necrosis[4].Pooling of the data from these 183 patients by Bosscha and colleagues in a meta-analysis resulted...
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Báo cáo y học:

Báo cáo y học: "Bench-to-bedside review: Hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers" ppt

... variation in insulin dosing in the casesreporting the use of HIET in CCB overdose and in the duration of treatment, rational recommendations couldcurrently consist of the administration of 1.0 ... hypokalaemiamay offer benefit by promoting cellular calcium entry and increasing the inotropic effect of insulin [21,24].Recommendations for the use of HIET in CCBpoisoningAlthough there is wide ... toxicity of all other CCBs, including dihydropyridine and benzothiazepine agents, is unknown.Supporting clinical dataAdult clinical experience In 1999, Yuan and colleagues [21] reported the case of...
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Báo cáo y học:

Báo cáo y học: " HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain" doc

... clarifying why oligomer formation is essentialfor Rev activity by assessing the requirements for restora-tion of the activity of the mutant.Results The intracellular localization of Rev and ... mutants The intracellular distribution of the M4 and the M4derived Rev mutants (schematically outlined in figure 1)were tested by immunofluorescence in the absence orpresence of 5 nM Leptomycin ... shows the results of three or more additional and independent experimentsrelated to the activity of wild type Rev, the negative con-trol and to the relative amount of cell lysates in the sam-ples....
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Báo cáo y học: "A novel scheme to assess factors involved in the reproducibility of DNA-microarray data" pdf

... preference of the reverse transcriptase enzyme for the Cy3 label and (ii) prolonged exposure to air and light of the dyes increasing the chance of oxidation and / or bleaching. The main contributing ... presented by coefficient of variance (CV). CVs are calculated by dividing the standard deviation (SD) by the mean ratio of a gene and multiplying by 100%. The minimum and maximum numbers of measurements ... DNA-microarray data quality. In order to assess the reproducibility of- and factors involved in DNA-microarray data produced in our laboratory during transcriptome analyses by a number of researchers,...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

... l-lysine, l-serine, b-alanine, taurine, sarcosine,dimethylglycine, glycine betaine, trimethylamine N-oxide, and cytidine 2¢-3¢ cyclic monophosphate were also obtainedfrom Sigma. These and other ... advances in understanding the effect of osmolytes on protein stability, folding and the activity of proteins and enzymes, the relationshipbetween protein stabilization by osmolytes and its con-sequent ... that protein stability and activity are not largelycoupled in the presence of osmolytes. However, proteinstability and activity have a linear correlation in the presence of methylamines and sugar...
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