... suggesting that Tregs indeed contri-bute to effector T cell dysfunction and inability to clear the infection. Acute HIV-1 infection is usually charact erized by mildflu-like symptoms and henc ... infected lymphatic tissues,suggesting that Tregs either redistribute to infected tissues,proliferate there, or both [36,55]. Tregs at the sites of infection are associated with dysfunctional ... infection, and allowing the establishment of a chronic infection. The interplay of different subsets of CD4 + T cells in FV infection and the relevance to HIV infection in humans will be discussed in this...