Báo cáo y học: "Brain dysfunction in sepsis: what can we learn from cerebral perfusion studies" pdf

... of inflammatory mediators on the brain.Investigations addressing SAD will remain difficult due to theproblem of correctly identifying and quantifying this entity.The value of monitoring cerebral ... one could speculate that, in analogy totraumatic brain injury, severe brain dysfunction is necessaryto disturb CO2reactivity. The action of inflammatorymediators on the endothelium has been ... cerebral perfusion and cerebro-vascular reactivity in this setting remains to be defined.However, further experimental and clinical investigations onSAD are important and carefully controlled...

Báo cáo y học: "Maintenance care in chiropractic – what do we know" ppsx

... study, all with persistent low back pain at baseline, only 14% were reported by their chiropractors tohave received some type of maintenance care during thesubsequent year [17]. In summary, ... the use of maintenance care can affect thepatient turnover was shown in the Leboeuf et al study from Australia [16]. We were unable to find any information on which factorsplay a role, when ... theefficacy of maintenance care in one well-designed pilotstudy, in which 29 patients with chronic low back painwere randomly allocated to either a non-maintenancecare group or a maintenance...

Báo cáo y học: "Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis" pps

... RA-induced and RA therapy-inducedhyperhomocysteinemia to CHF risk in RA has yet to becompletely elucidated.Inflammatory cytokines In patients with overt CHF, levels of inflammatory cytokines(TNF-α, ... myocardium in RA in either anendocrine (originating in the synovium) or paracrine (produced in the local environment of the progressively failingmyocardium) fashion, contributing to subclinical ... pre-clinicalstudies linking inflammation to CHF and the lack of efficacy ofanti-cytokine therapy in clinical trials in advanced CHF(discussed below). Because anti-cytokine therapy hasbecome a cornerstone in...

Báo cáo y học: "Coagulation cascade in sepsis: getting from bench to bedside" pot

... basic research. Thepotential key role of proteins that were originally believed tobe exclusively involved in coagulation in the inflammatoryresponse provides an exciting potential mechanism(s) ... is unlikelythat any new therapies resulting from the new knowledge ofCommentaryCoagulation cascade in sepsis: getting from bench to bedside?Glen BrownClinical Coordinator, Pharmacy Department, ... Theaccompanying review by Riewald and Ruf [1] outlines theavailable information on the possible steps involving some ofthe various proteins that are common to both coagulationand inflammation....

Báo cáo y học: "Myocardial protection in sepsis" potx

... myocardial infarction werereduced. Hypotension was very instrumental in causing theadverse events. Interestingly, sepsis and infection were alsoclearly more common on metoprolol.CommentaryMyocardial ... whenusing β-blockers in acute settings of hemodynamic com-promise. The COMMIT trial in acute myocardial infarctionshowed that metoprolol’s benefit in reducing reinfarction andarrhythmia (10 ... commonly utilized during goal directed therapy tosupport oxygen delivery and maintain perfusion pressure [2,3].There is a large body of evidence suggesting that excessiveadrenergic levels can...

Báo cáo y học: "Gastrointestinal dysfunction in the critically ill: can we measure it" doc

... scale for measuring gastrointestinal dys-function, using as descriptors, feeding intolerance and intra-abdominal hypertension. They demonstrate convincingly thattheir Gastrointestinal Failure ... online http://ccforum.com/content/12/5/180AbstractGastrointestinal dysfunction is an intuitively important, yetdescriptively elusive component of the multiple organ dysfunction syndrome. Reintam ... ofgastrointestinal dysfunction is novel, and reflects morbiditythat was underappreciated 10 years ago, their scale fallsshort in providing a comprehensive measure of gastro-intestinal dysfunction...

Báo cáo y học: "Neuroimmune perspectives in sepsis" pps

... ischemia and reperfusion. NF-κB inhibitionproduces different effects in enterocytes, however, and can prevent intestinal derangements during sepsis. These studiessuggest that the ubiquitous inhibition ... decreases during the progres-sion of sepsis, however, and can become insufficient for thehomeostasis of the cardiovascular system (as indicated bythe need for catecholamine administration during septicshock) ... nicotinic receptors that can limitthe anti-inflammatory potential of the vagus nerve. Since thehalf-life of ketamine is approximately 3 hours, this anestheticmay limit the effect of sympatholytics...

Báo cáo y học: "Cell death in sepsis: a matter of how, when, and where" potx

... andactually exacerbate liver injury [9]. In addition to apoptosis, certain caspases, such as caspase-1,are involved in cytokine maturation by proteolytically proces-sing the inactive precursors of interleukin ... Neverthe-less, these promising findings must be tempered by the newstudy showing that multiple pathways might be activated in dying cells during sepsis [1]. The simple inhibition of aparticular ... Furthermore,apoptosis of gastrointestinal epithelial cells may compromisethe integrity of the bowel wall, resulting in the translocation ofbacteria or endotoxins into the systemic circulation. A contri-bution...

Báo cáo y học: "Renal dysfunction in chronic liver disease" potx

... kidney injury biomarkers in both serum and urine have been discovered using genomic and proteomic technology and they are demonstrating superiority in detecting kidney injury before changes in ... of creatine, which is produced in the liver from three amino acids, methionine, arginine, and glycine, and stored in muscle to be used as a source of energy once phosporylated. Creatinine does ... amyloidosis polyneuropathy is an autosomal dominant disease caused by a point mutation in the gene coding for transthyretin, also called pre-albumin.  e amino acid, valine, is replaced by...

Báo cáo y học: " Immune status in sepsis: the bug, the site of infection and the severity can make the difference" docx

... signiﬁ cant diﬀ erences in terms of the number of circulating NK cells, CD4+ T lymphocytes, CD8+ T lymphocytes, and B lymphocytes was limited to community-acquired pneu-monia and intra-abdominal ... ammatory responses in the early phase of severe sepsis: longitudinal study of mononuclear histocompatibility leukocyte antigen-DR expression, procalcitonin, C-reactive protein, and changes in ... shock caused by nosocomial pneumonia. Finally, HLA-DR expression was particularly reduced in patients with severe sepsis or septic shock due to pyelonephritis or intra-abdominal infection. Altogether,...

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