... dehydratingintact brain, contracting healthy brain tissue volume, therebyaggravating pressure differentials, and causing devastatingshifts of brain tissue [6,42,44,58,62]. In malignant infarctions, ... De Georgia MA, Abou-Chebl A, Andrefsky JC, SilaCA, Katzan IL, Mayberg MR, Furlan AJ: Cooling for acute ischemic brain damage (COOL-AID): an open pilot study ofinduced hypothermia in acute ischemic ... brain into intravascularspaces. For the treatment of brain oedema after stroke,mannitol, glycerol, hydroxyethyl starch, and hypertonic salineare currently the most widely used [41]. According...