Báo cáo y học: "Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules" ppt
Báo cáo y học: "Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules" ppt
... citation purposes)RetrovirologyOpen AccessResearch Human T -cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion ... epithelial cells with MT-2resulted in infection with HTLV -I. Induction of expression of cytokines, chemokines and cell adhesion molecule in A549 cells cocultured with MT-2 cellsFigure 2Induction of ... Sugamura K, Fujii M, Kannagi M, Sakitani M, Takeuchi M, Hinuma Y: Cell surface phenotypes and expression of viral antigens of various human cell lines carrying human T -cell leukemia virus. Int J Cancer...
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Báo cáo y học: "Subacute herpes simplex virus type 1 encephalitis as an initial presentation of chronic lymphocytic leukemia and multiple sclerosis: a case report" doc
... immunosuppression from chroni c lymphocytic leukemia. This unusual case of herpes simplex virus type 1 encephalitis emphasizes the importance of T cell function in diseases of immune dysregulation and ... autoimmunity such as chronic lymphocytic leukemia and multiple sclerosis. It raises the question of whether atypical presentations of herpes simplex virus encephalitiswarrant deliberations on immunocompetence. ... patients with MS havefailed to find a statistically significant association [10].There is evidence of association b etween infection withEpstein-Barr virus (EBV) and subsequent diagnosis of MS,...
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Báo cáo Y học: Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression pdf
... alpha-Thrombininhibits signal transducers and activators of transcription 3 sig-naling by interleukin-6, leukemia inhibitory factor, and ciliaryneurotrophic factor in CCL39 cells. Arch. Biochem. Biophys. ... of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor alpha, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signalingpathways ... other regulatory proteins [13]. Speci®city of MAPKeffects in different cell types and in response to differentstimuli is achieved by the action of scaffolding proteins,which bring together the...
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Báo cáo hóa học: " Amphotropic murine leukemia virus is preferentially attached to cholesterol-rich microdomains after binding to mouse fibroblasts" pot
... of selection with medium containing 2 µg/ml puromycin,the cells were propagated in normal cultivation medium and used for investigations. Virus production of GagYFP A-MLV and VSVFor production of ... ER. Nat Cell Biol 2001, 3:473-483.5. Nguyen DH, Hildreth JE: Evidence for budding of human immu-nodeficiency virus type 1 selectively from glycolipid-enrichedmembrane lipid rafts. J Virol 2000, ... entryroute of A-MLV in NIH3T3 cells is via caveola [1], we herefound that the vast majority of cell- bound A-MLV virionsassociated with GM1-positive regions and not with cav-1-positive regions. Indeed,...
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Báo cáo y học: "Giantin is the major Golgi autoantigen in human anti-Golgi complex sera" pptx
... five antigens, five had antigiantin and antigolgin-245, two had antigiantin and antigolgin-160, two had antigiantin and anti-GM130, two had anti-giantin and antigolgin-97, two had antigolgin-245 ... representative human serum exhibiting staining specific to the Golgi complex in HEp-2 cells colocalizes with (b) characteristic staining by rabbit antigiantinantibody (arrows). (c) A serum with diffuse ... purifiedrecombinant proteins in an ELISA and by immunoprecipi-tation using extracts from [35S]-methionine labeled HeLa cells (Fig. 2). The number of positive sera and frequency of reactivity...
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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
... arthritis patients. The aim of this study was toelucidate which signal transduction pathway is involved in theTNF-α-mediated induction of Cyp7b activity in FLS. We studiedthe effects of inhibitors ... the possibility that inhibition of proteasome activity byPSI may interfere in other signal transduction pathways thatare independent of NF-κB [26].In this paper we show that inhibitors of the ... activity. SN50 (200 µg/ml) significantly reduced basal Cyp7b activity (Fig. 1a). Impor-tantly, the increase in Cyp7b activity following stimulation of the cells with TNF-α was dose-dependently inhibited...
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Báo cáo y học: "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthriti" pptx
... Germany).Sources of antibodiesThe anti-COMP antibody is a polyclonal rabbit-anti-bovineantibody that has been affinity-purified [1]. Affinity-purifiedsheep-anti-digoxigenin (DIG) antibodies ... Develop-ment of criteria for the classification and reporting of osteoar-thritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheuma-tism ... thatLRF/FBI-1 is the general transcription factor for the downreg-ulation of COMP and collagen type II [15]. If LRF/FBI-1 initiallydownregulates COMP and collagen type II in human OA,which in turn...
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Báo cáo y học: " Non-imprinted allele-specific DNA methylation on human autosomes" pptx
... allele-specific methylation and genetic polymorphisms, suggesting that the inter-individual variability of DNA methylation is strongly influenced by genetic differences. Therefore,genetic differences ... observation was madefor amplicons 23_1 and 23_2 (Additional file 6).Inter-individual variation of DNA methylationFigure 1Inter-individual variation of DNA methylation. (a) DNA methylation levels of ... epigeneticpathway connecting genetic polymorphisms and phenotypicvariability [20,21]. In the future, more genome-wide bisulfitesequencing DNA methylation analysis with DNA from differ-ent individuals will...
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Báo cáo y học: "Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms" pps
... unfavorable genotypes in DNA repair genes.Determination of the donor’s DNA repair genotype, cap-able of sti mulating genetic instability in a diseased recipi-ent, co uld be important for future ... those arising after treatmentwith DNA topoisomerase II inhibitors, such as anthracy-clines. Accordingly, AML’s developing after topoisome-rase II inhibitors are given typically show an early onset, and ... polymorphisms conferring sensitivity to che-motherapy, which may contribute to the incidence of secondary AML outcomes [24-26]. Alternatively, it ispossible that germline variations in DNA repair genesmay...
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Báo cáo y học: " Systemic Epstein-Barr-virus-positive T cell lymphoproliferative childhood disease in a 22-year-old Caucasian man: A case report and review of the literature" docx
... in Asians and Native Americans, and is associated with r apid progression,high morbidity and mortality. It can develop after primaryEBV infection or in association with chronic active EBVinfection ... CD8+LPD, and is cur-rently classified as systemic EBV+ T cell LPD of childhoodin the World Health Organization classification of tumors of hematopoietic and lymphoid tissues [5]. This entity is arare ... positivity, CD56 nega-tivity, and evidence of TCRa rearrangement in systemicEBV+T cell LPDs, and also sCD3/CD8 negativity, CD56positivity and germl ine TCRa patterns in aggressive NK cell leukemia...
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