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Báo cáo y học: " Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat" pptx

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Báo cáo y học: " Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat" pptx

... CentralPage 1 of 13(page number not for citation purposes)RetrovirologyOpen AccessResearch Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat Caroline ... Tat- inducedapoptosis [26]. Since apoptosis mediated by Tat partlyrelies on the interaction of Tat with tubulin [14-17], wehypothesized that zinc binding might play a role in the modulation by Tat of the microtubule ... favor of a distribution of SapparentSW200,Effect of zinc on Tat- RhB diffusion, as monitored by FCSFigure 2Effect of zinc on Tat- RhB diffusion, as monitored by FCS. The normalized autocorrelation...
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Báo cáo y học: " Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma" doc

... from airway inflammation.Conclusion: VD's modulation of airway inflammation may result from its inactivation of ERK1/2and downregulation of NPRA expression. Chitosan nanoparticles containing ... Downregulation of NPRA expression was also confirmed both in vitro and invivo by western blot and RT-PCR. Therefore, the observedattenuation of airway inflammation by VD is consistentwith ... activation in A549 cellsIncreased synthesis of nitric oxide (NO) during airwayinflammation caused by induction of nitric oxide syn-thase-2 in several lung cell types may contribute to epithe-lial...
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Tài liệu Báo cáo khoa học: Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae pptx

Tài liệu Báo cáo khoa học: Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae pptx

... are2D::HIS3MX6 This studyMLY20 YPH499 HIS3MX6-pGAL1-ARE2-9myc-klTRP1 This studyMLY21 YPH499 are1D::HIS3MX6 ste20D::klTRP1 This studyMLY28 YPH499 HIS3MX6-pGAL1-ARE1-9myc-klTRP1 This studyMLY84 YPH499 ... are1D::HIS3MX6 cla4D::kanMX6 This studyMLY115 YPH499 ARE1-9myc-HIS3MX6 This studyTHY310 YPH499 ste20D::klTRP1 [25]THY609 YPH499 cla4D::kanMX6 This studyTHY665 YPH499 swe1D::HIS3MX6 This studyTHY685 ... Topics inMedical Mycology (McGinnis MR ed), Vol 2, pp.388–418. Springer, New York, NY.53 Aoyama Y, Yoshida Y, Sonoda Y & Sato Y (1989)Deformylation of 32-oxo-24,25-dihydrolanosterol by...
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Báo cáo y học: "Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation" pps

... Corresponding author AbstractCystic Fibrosis (CF) is one of the most common autosomal genetic disorders in humans. Thisdisease is caused by mutations within a single gene, coding for the cystic ... by NFκB.FindingsCystic Fibrosis (CF) is one of the most common lethalautosomal recessive diseases in humans. It is caused by mutations within a single gene, coding for the cystic fibro-sis ... Inflammation in CF is regulated largely by activation of NFκB and transcrip-tion of pro-inflammatory genes regulated by this tran-scription factor [16,20]. Therefore, we examined the effect of WFA...
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Báo cáo y học: "A nuclear export signal within the structural Gag protein is required for prototype foamy virus replication" pdf

... retro-viruses, but is C-terminally cleaved by the viral protease,leading to the production of a G ag doublet during viralreplication. Moreover, FV Gag is not myristoylate d, andnone of the conventional ... supernatant was used to transduce293T cells, and GFP expression was monitored by flowcytometry forty-eight hours later. Remarkably, only the use of wild-type Gag led to the production of infectiousviruses ... Detection of the human lactate dehydrogenase (LDH) in cytoplasmic extracts only attests the validity of the fractionation assay (C: Cytoplasm, N: Nucleus).Renault et al. Retrovirology 2011,...
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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx

Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx

... absence of denaturant [44]. High-level drug resistance to TSAO is mediated by the E138K mutation in the p51 subunit of HIV-1 RT [55]. The introduction of this mutation into RTsignificantly diminishes ... primarily from the palm, connection and RNase H domain, while in the p51they arise from the fingers, thumb and connection domains.Dissection of the contributions of each individual residue to the total ... 2002 Modulation of the quaternary structure of HIV-1 enzymes (Eur. J. Biochem. 269) 5107 HIV-1 PROTEASEStructure and function of HIV-1 PR HIV-1 PR catalyzes the hydrolysis of specific peptide bondswithin...
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Báo cáo Y học: Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition ppt

Báo cáo Y học: Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition ppt

... respectively. This confirms the observed activity dependence of PEP inhibition on Ins(1,4,5)P3concentration.Influence of PEP inhibition on the cAMP pathwayIn addition to Ins(1,4,5)P3, the effect of ... Auerswald, E.A. (1995) Temporary inhibition of papain by hairpin loop mutants of chicken cystatin. Distorted binding of the loops results in cleavage of the Gly(9)-Ala10 bond.FEBS Lett. 361, 185–190.26. ... function is far frombeing fully understood [5,6]. Highly conserved in mam-mals, it is ubiquitously distributed, with high concentra-tions in the brain [7]. Recently, the enzyme became of pharmaceutical...
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Báo cáo y học: "Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium" ppt

... This effect is consistent with the well estab-lished inhibitory effect of ALP on the cytoskeletal reorganiza-tion of stimulated granulocytes and the accompanyingsuppression of conformational ... postcapillary endothelium by ALP in vivoInhibition of leukocyte interaction with the postcapillary endothelium by ALP in vivo. (a) Inhibition of leukocyte rolling along the postcapillary endothelium by ... leukocytes,complement each other in their anti-inflammatory effect. Thissynergism may contribute to the established capacity of ALP to block leukocyte infiltration and tissue injury in a variety of experimental...
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Báo cáo y học: "Modulation of LPS stimulated NF-kappaB mediated Nitric" pptx

... unstimulated conditions, p65 is restricted to the cytoplasm by a set of inhibitory proteins and, upon stim-ulation, translocated to the nucleus. This stimulation canbe modulated by phosphorylation of ... in this study (50 ng/ml) [28]. The induction of NOS2 activity upon activation of PKC by LPS stimulationhas also been demonstrated previously using a non-selec-tive inhibitor of all PKC isoforms ... production during an inflammatory response. NF-κB activation is regulated by distinct kinasepathways independent of inhibitor of κB kinase (IKK). Here, we examine the role of protein kinaseC isoforms...
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Báo cáo y học: "Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults" ppsx

... pathogens. Thissystem is based on primed T and B lymphocytes thatmigrate from the site of antigen presentation via lymphat-ics and blood to selectively "home" to lymphoid tissue atdistant ... gastrointestinal, respiratory, genitourinaryand other mucosa-associated regions [17].In this context, the objective of this study was to analysehumoral and cellular immune responses to mycobacterialantigens ... little is known of the induced immune response. The aim of this studywas to analyse immunological responses after oral vaccination with M. bovis BCG Moreau RDJ.Methods: This study in healthy volunteers...
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