... respectively. This confirms the observed activity dependence of PEP inhibition on Ins(1,4,5)P3concentration.Influence of PEP inhibition on the cAMP pathwayIn addition to Ins(1,4,5)P3, the effect of ... Auerswald, E.A. (1995) Temporary inhibition of papain by hairpin loop mutants of chicken cystatin. Distorted binding of the loops results in cleavage of the Gly(9)-Ala10 bond.FEBS Lett. 361, 185–190.26. ... function is far frombeing fully understood [5,6]. Highly conserved in mam-mals, it is ubiquitously distributed, with high concentra-tions in the brain [7]. Recently, the enzyme became of pharmaceutical...