Báo cáo khoa học: " Nitric oxide inhibition rapidly increases blood pressure with no change in outcome in cardiogenic shock: the TRIUMPH trial" pptx
Báo cáo khoa học: " Nitric oxide inhibition rapidly increases blood pressure with no change in outcome in cardiogenic shock: the TRIUMPH trial" pptx
... medicine is all about. Furthermore, the tilarginine-induced increase in systolic blood pressure leads toquestions about the use of systolic blood pressure as asurrogate endpoint to predict outcome ... outcome in CS.Overall, treatments targeting the inflammatory cascade,especially the inhibition of the NO pathway, remain asdeceiving in MI as in sepsis. This might be related to the useof a non-specific ... mortality. There was, however, a 6%absolute increase in 30-day mortality in the tilarginine group(48%, versus 42% in the placebo) that was qualified byNdrepepa and colleagues in their editorial in the...
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Báo cáo khoa học: Nitric oxide formation from the reaction of nitrite with carp and rabbit hemoglobin at intermediate oxygen saturations pdf
... min8 min11 min14 min17 min23 min32 min41 min50 min59 min74 min90 min110 min140 min180 minABFig. 1. Spectral changes during the reaction of nitrite with carphemoglobin at different ... min11 min14 min17 min23 min32 min41 min50 min59 min68 min77 mindeoxyHbmixture of HbNOand metHb450 500 550 600 650 7000.00.51.01.52.02.5Wavelength (nm)0 min2 min5 min8 min11 ... assessed the in uence of increasing the Po2 in carp Hb after the reaction with nitrite had been started, toevaluate the effects of a rapid change in So2on the courseof the reaction. A Po2increase...
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Báo cáo khoa học: Nitric oxide-induced epidermal growth factor-dependent phosphorylations in A431 tumour cells pot
... NONOate family [39] inversely correlates with the magnitude of the observed inhibition of the phosphory-lation of EGFR in intact cells. NONOates, in contrast with other NO •donors such as SNAP ... signal-regulatedprotein kinases 1 and 2; JNK1/2, c-Jun N-terminal kinases 1 and 2;MAPK, mitogen-activated protein kinase; MEK, MAP/ERK kinase;NOIPP-58, nitric oxide- induced 58 kDa phosphoprotein; NOS, nitric oxide ... and induces the phosphorylation at tyrosine residue(s) of a 58-kDa proteinwhich we have denoted NOIPP-58 (nitric oxide- induced58-kDa phosphoprotein). The NO •-induced phosphoryla-tion of NOIPP-58...
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Báo cáo khoa học: Utp25p, a nucleolar Saccharomyces cerevisiae protein, interacts with U3 snoRNP subunits and affects processing of the 35S pre-rRNA docx
... whether Utp25p binds directly to the snoRNA U3 or associates via interaction with the proteins Sas10p and Mpp10p remains to beaddressed. The fact that no known RNA-bindingmotifs can be distinguished ... C-terminalportion, divergences in the remaining sequence of the protein would render hUtp25p nonfunctional and ⁄ orunstable in yeast.To analyze the possibility that the C-terminalDUF1253 domain ... Snu13p [8]. In addition to the core proteins, the U3 snoRNP is asso-ciated with other proteins specific for this snoRNP. The first proteins to be identified in the U3 snoRNPcomplex were Sof1p,...
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Báo cáo khoa học: "Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy" pot
... materialCompeting interests The authors declare that they have no competing interests in this study.Authors' contributionsGZ and AS participated in the design of the study and performed the statisticalanalysis ... radiochemotherapy with vinorelbine plus cisplatin or carboplatin in patients with locally advanced non-small-cell lung cancer (NSCLC) and an increased risk of treatment complications: Preliminary ... pulmonary fibrosis associated with induction chemotherapy with carboplatin and vinorelbine followed by CHART radiotherapy for locally advanced non-small cell lung cancer. Clin Oncol 2002, 14:361-366.6....
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Báo cáo khoa học: " Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer" potx
... address this issue. In our large single-institution study, we report the clinical outcome and pattern of failure of 3D-CRT without ENI in treating NSCLC after staging with PET scanning.MethodsPatient ... treated at our institution with definitive radiation therapy with or without concurrentchemotherapy (CHT). All patients were treated with 3D-CRT, including nodal regions determinedby CT or PET ... toverify the lymph node involvement for suspicious lymphnodes in GTV delineation. This procedure may furtherimprove the accuracy of lymph node staging and targetdelineation. It should be noted,...
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Báo cáo khoa học: "Recently published papers: An ancient debate, novel monitors and post ICU outcome in the elderly" potx
... central venous blood samples were obtained, along with measurement of cardiacindices using the thermodilution technique. The group foundexcellent correlation between Cv–aCO2and Mv–aCO2, with ... regarding the indications, timing and technique fortracheostomy seems to have been raging ever since the procedure itself was first described in ancient Egypt [1]. The topic is of global interest, ... following intubation, andlate was defined as any time thereafter, if at all. The resultsshowed that the duration of artificial ventilation wassignificantly lower in the early group, as was the...
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Báo cáo khoa học: "Effects of descending positive end-expiratory pressure on lung mechanics and aeration in healthy anaesthetized piglets" docx
... purpose-builtroutine written in MatLab (Mathworks). The lung contours,including the mediastinum, were traced manually to define the region of interest. The presence of hyperinflation (-1,000 ... areas at the expense of hyperinflating otherwise normally aerated areas, in non-dependent lung regions, suggesting that the hiddeneffect of PEEP is the overdistension of some alveoli. The bio-logical ... manoeuvres after setting the PEEP at the minimum of the Ers was not assessed here; this might merit fur-ther study.Pure oxygen was used in the present protocol, an atypical sit-uation with...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric oxide ... provide increased substrate for arginase (50). No significant changes in the activity of arginase in the anoxic group indicate that there is no enhanced utili-zation of arginine by this enzyme in ... disorders and in brain function. To understand their role in anoxia (hypobaric hypoxia) and reperfusion (reoxygenation), the nitric oxide synthase, argi-ninosuccinate synthetase, argininosuccinate...
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Báo cáo khoa học: Efficient inhibition of b-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes doc
... generated with the help of the MFOLDprogram [33] shows that the 5¢-GUC665-3¢ target sequence is not involved in hydrogenbonding. However, the availability of the 5¢-CUC825-3¢triplet, which is the ... factorsincluding their intracellular concentration, an effectiveexport from the nucleus to the cytoplasm, a colocalizationof the ribozyme with the target RNA and the availability of the target ... (datanot shown).Activity of ribozymes in HEK293 cellsAt first we checked the activity of the ribozymes bydetermining the level of the target mRNA in tested cellstransfected with ribozyme encoding...
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